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Article: IFN-γ-dependent NK cell activation is essential to metastasis suppression by engineered Salmonella

TitleIFN-γ-dependent NK cell activation is essential to metastasis suppression by engineered Salmonella
Authors
Issue Date2021
PublisherNature Research: Fully open access journals. The Journal's web site is located at http://www.nature.com/ncomms/index.html
Citation
Nature Communications, 2021, v. 12 n. 1, p. article no. 2537 How to Cite?
AbstractMetastasis accounts for 90% of cancer-related deaths and, currently, there are no effective clinical therapies to block the metastatic cascade. A need to develop novel therapies specifically targeting fundamental metastasis processes remains urgent. Here, we demonstrate that Salmonella YB1, an engineered oxygen-sensitive strain, potently inhibits metastasis of a broad range of cancers. This process requires both IFN-γ and NK cells, as the absence of IFN-γ greatly reduces, whilst depletion of NK cells in vivo completely abolishes, the anti-metastatic ability of Salmonella. Mechanistically, we find that IFN-γ is mainly produced by NK cells during early Salmonella infection, and in turn, IFN-γ promotes the accumulation, activation, and cytotoxicity of NK cells, which kill the metastatic cancer cells thus achieving an anti-metastatic effect. Our findings highlight the significance of a self-regulatory feedback loop of NK cells in inhibiting metastasis, pointing a possible approach to develop anti-metastatic therapies by harnessing the power of NK cells.
Persistent Identifierhttp://hdl.handle.net/10722/306106
ISSN
2023 Impact Factor: 14.7
2023 SCImago Journal Rankings: 4.887
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLin, Q-
dc.contributor.authorRONG, L-
dc.contributor.authorJia, X-
dc.contributor.authorLI, R-
dc.contributor.authorYu, B-
dc.contributor.authorHu, J-
dc.contributor.authorLuo, X-
dc.contributor.authorBadea, SR-
dc.contributor.authorXU, C-
dc.contributor.authorFu, G-
dc.contributor.authorLai, K-
dc.contributor.authorLee, MC-
dc.contributor.authorZhang, B-
dc.contributor.authorGong, H-
dc.contributor.authorZhou, N-
dc.contributor.authorChen, XL-
dc.contributor.authorLin, SH-
dc.contributor.authorFu, G-
dc.contributor.authorHuang, JD-
dc.date.accessioned2021-10-20T10:18:52Z-
dc.date.available2021-10-20T10:18:52Z-
dc.date.issued2021-
dc.identifier.citationNature Communications, 2021, v. 12 n. 1, p. article no. 2537-
dc.identifier.issn2041-1723-
dc.identifier.urihttp://hdl.handle.net/10722/306106-
dc.description.abstractMetastasis accounts for 90% of cancer-related deaths and, currently, there are no effective clinical therapies to block the metastatic cascade. A need to develop novel therapies specifically targeting fundamental metastasis processes remains urgent. Here, we demonstrate that Salmonella YB1, an engineered oxygen-sensitive strain, potently inhibits metastasis of a broad range of cancers. This process requires both IFN-γ and NK cells, as the absence of IFN-γ greatly reduces, whilst depletion of NK cells in vivo completely abolishes, the anti-metastatic ability of Salmonella. Mechanistically, we find that IFN-γ is mainly produced by NK cells during early Salmonella infection, and in turn, IFN-γ promotes the accumulation, activation, and cytotoxicity of NK cells, which kill the metastatic cancer cells thus achieving an anti-metastatic effect. Our findings highlight the significance of a self-regulatory feedback loop of NK cells in inhibiting metastasis, pointing a possible approach to develop anti-metastatic therapies by harnessing the power of NK cells.-
dc.languageeng-
dc.publisherNature Research: Fully open access journals. The Journal's web site is located at http://www.nature.com/ncomms/index.html-
dc.relation.ispartofNature Communications-
dc.rightsNature Communications. Copyright © Nature Research: Fully open access journals.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleIFN-γ-dependent NK cell activation is essential to metastasis suppression by engineered Salmonella-
dc.typeArticle-
dc.identifier.emailHuang, JD: jdhuang@hku.hk-
dc.identifier.authorityHuang, JD=rp00451-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1038/s41467-021-22755-3-
dc.identifier.pmid33953170-
dc.identifier.pmcidPMC8099885-
dc.identifier.scopuseid_2-s2.0-85105364088-
dc.identifier.hkuros327274-
dc.identifier.volume12-
dc.identifier.issue1-
dc.identifier.spagearticle no. 2537-
dc.identifier.epagearticle no. 2537-
dc.identifier.isiWOS:000656480900004-
dc.publisher.placeUnited Kingdom-

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