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Article: Fronto-cerebellar connectivity mediating cognitive processing speed

TitleFronto-cerebellar connectivity mediating cognitive processing speed
Authors
KeywordsProcessing speed
Individual differences
Connectivity
Medial frontal cortex
Cerebellum
Issue Date2021
PublisherElsevier: Creative Commons. The Journal's web site is located at http://www.elsevier.com/locate/ynimg
Citation
NeuroImage, 2021, v. 226, p. article no. 117556 How to Cite?
AbstractProcessing speed is an important construct in understanding cognition. This study was aimed to control task specificity for understanding the neural mechanisms underlying cognitive processing speed. Forty young adult subjects performed attention tasks of two modalities (auditory and visual) and two levels of task rules (compatible and incompatible). Block-design fMRI captured BOLD signals during the tasks. Thirteen regions of interest were defined with reference to publicly available activation maps for processing speed tasks. Cognitive speed was derived from task reaction times, which yielded six sets of connectivity measures. Mixed-effect LASSO regression revealed six significant paths suggestive of a cerebello-frontal network predicting the cognitive speed. Among them, three are long range (two fronto-cerebellar, one cerebello-frontal), and three are short range (fronto-frontal, cerebello-cerebellar, and cerebello-thalamic). The long-range connections are likely to relate to cognitive control, and the short-range connections relate to rule-based stimulus-response processes. The revealed neural network suggests that automaticity, acting on the task rules and interplaying with effortful top–down attentional control, accounts for cognitive speed.
Persistent Identifierhttp://hdl.handle.net/10722/306125
ISSN
2023 Impact Factor: 4.7
2023 SCImago Journal Rankings: 2.436
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWong, HY-
dc.contributor.authorLiu, J-
dc.contributor.authorLee, TMC-
dc.contributor.authorTao, J-
dc.contributor.authorWong, AWK-
dc.contributor.authorChau, BKH-
dc.contributor.authorChen, L-
dc.contributor.authorChan, CCH-
dc.date.accessioned2021-10-20T10:19:08Z-
dc.date.available2021-10-20T10:19:08Z-
dc.date.issued2021-
dc.identifier.citationNeuroImage, 2021, v. 226, p. article no. 117556-
dc.identifier.issn1053-8119-
dc.identifier.urihttp://hdl.handle.net/10722/306125-
dc.description.abstractProcessing speed is an important construct in understanding cognition. This study was aimed to control task specificity for understanding the neural mechanisms underlying cognitive processing speed. Forty young adult subjects performed attention tasks of two modalities (auditory and visual) and two levels of task rules (compatible and incompatible). Block-design fMRI captured BOLD signals during the tasks. Thirteen regions of interest were defined with reference to publicly available activation maps for processing speed tasks. Cognitive speed was derived from task reaction times, which yielded six sets of connectivity measures. Mixed-effect LASSO regression revealed six significant paths suggestive of a cerebello-frontal network predicting the cognitive speed. Among them, three are long range (two fronto-cerebellar, one cerebello-frontal), and three are short range (fronto-frontal, cerebello-cerebellar, and cerebello-thalamic). The long-range connections are likely to relate to cognitive control, and the short-range connections relate to rule-based stimulus-response processes. The revealed neural network suggests that automaticity, acting on the task rules and interplaying with effortful top–down attentional control, accounts for cognitive speed.-
dc.languageeng-
dc.publisherElsevier: Creative Commons. The Journal's web site is located at http://www.elsevier.com/locate/ynimg-
dc.relation.ispartofNeuroImage-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectProcessing speed-
dc.subjectIndividual differences-
dc.subjectConnectivity-
dc.subjectMedial frontal cortex-
dc.subjectCerebellum-
dc.titleFronto-cerebellar connectivity mediating cognitive processing speed-
dc.typeArticle-
dc.identifier.emailWong, HY: hycwong@hku.hk-
dc.identifier.emailLee, TMC: tmclee@hku.hk-
dc.identifier.authorityLee, TMC=rp00564-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1016/j.neuroimage.2020.117556-
dc.identifier.pmid33189930-
dc.identifier.scopuseid_2-s2.0-85096820069-
dc.identifier.hkuros328010-
dc.identifier.volume226-
dc.identifier.spagearticle no. 117556-
dc.identifier.epagearticle no. 117556-
dc.identifier.isiWOS:000608035900032-
dc.publisher.placeUnited States-

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