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Article: Bone microarchitectural alterations in boys with Duchenne muscular dystrophy on long-term glucocorticoid treatment

TitleBone microarchitectural alterations in boys with Duchenne muscular dystrophy on long-term glucocorticoid treatment
Authors
KeywordsDuchenne muscular dystrophy
Osteoporosis
HR-pQCT
Glucocorticoid
Bone microarchitecture index
Issue Date2021
PublisherSpringer Japan. The Journal's web site is located at http://link.springer.de/link/service/journals/00774/index.htm
Citation
Journal of Bone and Mineral Metabolism, 2021, v. 39 n. 4, p. 606-611 How to Cite?
AbstractIntroduction: Osteoporosis is a major health issue in boys with Duchenne muscular dystrophy (DMD). Data on the specific bone deficits and microarchitectural alterations in children with DMD were limited. This study aimed to assess the bone microarchitectural alterations in boys with DMD on long-term glucocorticoid using high-resolution peripheral quantitative computed tomography (HR-pQCT). Materials and methods: This was a cross-sectional, case–control study. Boys with DMD older than 5 years with no prior history of symptomatic fracture and had been on long-term glucocorticoid treatment were recruited from a single tertiary centre. For each participant, three gender- and age-matched controls were selected randomly from an existing HR-pQCT database of healthy individuals. Results: Nine boys with DMD at a median age of 9.3 years were included. Three were found to have asymptomatic vertebral compression fracture. The HR-pQCT findings of these nine boys were compared with 27 healthy controls. Trabecular microstructure indices at the distal radius were significantly lower but the cortical vBMD was significantly higher in the DMD boys when compared with healthy controls. Conclusion: Lower microarchitectural measurement of trabecular bones, but higher cortical vBMD, was observed in DMD boys on long-term oral glucocorticoid. The results from this study provide preliminary, yet important insights into the bone microarchitecture of this group of patients.
Persistent Identifierhttp://hdl.handle.net/10722/306167
ISSN
2023 Impact Factor: 2.4
2023 SCImago Journal Rankings: 0.766
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTung, JYL-
dc.contributor.authorLam, TP-
dc.contributor.authorChan, SHS-
dc.date.accessioned2021-10-20T10:19:44Z-
dc.date.available2021-10-20T10:19:44Z-
dc.date.issued2021-
dc.identifier.citationJournal of Bone and Mineral Metabolism, 2021, v. 39 n. 4, p. 606-611-
dc.identifier.issn0914-8779-
dc.identifier.urihttp://hdl.handle.net/10722/306167-
dc.description.abstractIntroduction: Osteoporosis is a major health issue in boys with Duchenne muscular dystrophy (DMD). Data on the specific bone deficits and microarchitectural alterations in children with DMD were limited. This study aimed to assess the bone microarchitectural alterations in boys with DMD on long-term glucocorticoid using high-resolution peripheral quantitative computed tomography (HR-pQCT). Materials and methods: This was a cross-sectional, case–control study. Boys with DMD older than 5 years with no prior history of symptomatic fracture and had been on long-term glucocorticoid treatment were recruited from a single tertiary centre. For each participant, three gender- and age-matched controls were selected randomly from an existing HR-pQCT database of healthy individuals. Results: Nine boys with DMD at a median age of 9.3 years were included. Three were found to have asymptomatic vertebral compression fracture. The HR-pQCT findings of these nine boys were compared with 27 healthy controls. Trabecular microstructure indices at the distal radius were significantly lower but the cortical vBMD was significantly higher in the DMD boys when compared with healthy controls. Conclusion: Lower microarchitectural measurement of trabecular bones, but higher cortical vBMD, was observed in DMD boys on long-term oral glucocorticoid. The results from this study provide preliminary, yet important insights into the bone microarchitecture of this group of patients.-
dc.languageeng-
dc.publisherSpringer Japan. The Journal's web site is located at http://link.springer.de/link/service/journals/00774/index.htm-
dc.relation.ispartofJournal of Bone and Mineral Metabolism-
dc.rightsThis version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s00774-020-01196-w-
dc.subjectDuchenne muscular dystrophy-
dc.subjectOsteoporosis-
dc.subjectHR-pQCT-
dc.subjectGlucocorticoid-
dc.subjectBone microarchitecture index-
dc.titleBone microarchitectural alterations in boys with Duchenne muscular dystrophy on long-term glucocorticoid treatment-
dc.typeArticle-
dc.identifier.emailChan, SHS: sophehs@hku.hk-
dc.identifier.authorityChan, SHS=rp02210-
dc.description.naturepostprint-
dc.identifier.doi10.1007/s00774-020-01196-w-
dc.identifier.pmid33400004-
dc.identifier.scopuseid_2-s2.0-85098959405-
dc.identifier.hkuros328072-
dc.identifier.volume39-
dc.identifier.issue4-
dc.identifier.spage606-
dc.identifier.epage611-
dc.identifier.isiWOS:000605137600001-
dc.publisher.placeJapan-

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