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- Publisher Website: 10.1155/2021/6651318
- Scopus: eid_2-s2.0-85107011000
- PMID: 34055992
- WOS: WOS:000659124000004
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Article: Comparison of Vascular Morphometry in Jawbones and Long Bones: Micro-CT Study in a Rat Model Treated with Zoledronic Acid
Title | Comparison of Vascular Morphometry in Jawbones and Long Bones: Micro-CT Study in a Rat Model Treated with Zoledronic Acid |
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Authors | |
Editors | Editor(s):Ramoji, K |
Issue Date | 2021 |
Publisher | Hindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/jbb/index.html |
Citation | BioMed Research International, 2021, v. 2021, p. article no. 6651318 How to Cite? |
Abstract | The study was aimed at investigating the effect of zoledronic acid on vascular morphometry in jawbones and long bones on a rat model. Twenty-four skeletal mature Sprague-Dawley female rats were administered oncologic dose of zoledronic acid (ZA) or normal saline for 4 weeks and then subjected to tooth extraction on the mandible and maxilla and a bone defect creation on the femur. After the surgical procedures, ZA or saline treatment was continued until sacrifice at week 2, week 4, and week 8 postoperatively. Vascular perfusion with MICROFIL was performed on all the animals. Micro-CT analysis demonstrated a tendency of decreased vessel density and vessel number in ZA-treated groups but no statistical difference. In conclusion, the neovessel formation is suppressed but not significantly by ZA treatment, indicating that angiogenesis inhibition may contribute to the development of MRONJ but does not play a key role. |
Persistent Identifier | http://hdl.handle.net/10722/306329 |
ISSN | 2021 Impact Factor: 3.246 2020 SCImago Journal Rankings: 0.772 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | WANG, JY | - |
dc.contributor.author | YU, RQ | - |
dc.contributor.author | HUO, L | - |
dc.contributor.author | RAO, NJ | - |
dc.contributor.author | Lu, WW | - |
dc.contributor.author | Zheng, LW | - |
dc.contributor.editor | Ramoji, K | - |
dc.date.accessioned | 2021-10-20T10:22:04Z | - |
dc.date.available | 2021-10-20T10:22:04Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | BioMed Research International, 2021, v. 2021, p. article no. 6651318 | - |
dc.identifier.issn | 2314-6133 | - |
dc.identifier.uri | http://hdl.handle.net/10722/306329 | - |
dc.description.abstract | The study was aimed at investigating the effect of zoledronic acid on vascular morphometry in jawbones and long bones on a rat model. Twenty-four skeletal mature Sprague-Dawley female rats were administered oncologic dose of zoledronic acid (ZA) or normal saline for 4 weeks and then subjected to tooth extraction on the mandible and maxilla and a bone defect creation on the femur. After the surgical procedures, ZA or saline treatment was continued until sacrifice at week 2, week 4, and week 8 postoperatively. Vascular perfusion with MICROFIL was performed on all the animals. Micro-CT analysis demonstrated a tendency of decreased vessel density and vessel number in ZA-treated groups but no statistical difference. In conclusion, the neovessel formation is suppressed but not significantly by ZA treatment, indicating that angiogenesis inhibition may contribute to the development of MRONJ but does not play a key role. | - |
dc.language | eng | - |
dc.publisher | Hindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/jbb/index.html | - |
dc.relation.ispartof | BioMed Research International | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.title | Comparison of Vascular Morphometry in Jawbones and Long Bones: Micro-CT Study in a Rat Model Treated with Zoledronic Acid | - |
dc.type | Article | - |
dc.identifier.email | Lu, WW: wwlu@hku.hk | - |
dc.identifier.email | Zheng, LW: lwzheng@hkucc.hku.hk | - |
dc.identifier.authority | Lu, WW=rp00411 | - |
dc.identifier.authority | Zheng, LW=rp01411 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1155/2021/6651318 | - |
dc.identifier.pmid | 34055992 | - |
dc.identifier.pmcid | PMC8133839 | - |
dc.identifier.scopus | eid_2-s2.0-85107011000 | - |
dc.identifier.hkuros | 327881 | - |
dc.identifier.volume | 2021 | - |
dc.identifier.spage | article no. 6651318 | - |
dc.identifier.epage | article no. 6651318 | - |
dc.identifier.isi | WOS:000659124000004 | - |
dc.publisher.place | United States | - |