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Article: Brij-functionalized chitosan nanocarrier system enhances the intestinal permeability of P-glycoprotein substrate-like drugs

TitleBrij-functionalized chitosan nanocarrier system enhances the intestinal permeability of P-glycoprotein substrate-like drugs
Authors
KeywordsBrij-grafted-chitosan
Oral nanocarrier
P-glycoprotein
Berberine
Diabetic kidney disease
Issue Date2021
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/carbpol
Citation
Carbohydrate Polymers, 2021, v. 266, p. article no. 118112 How to Cite?
AbstractThe highly expressed P-glycoprotein (Pgp) in the intestine plays a key role in preventing drugs across the intestinal epithelium, which linked by tight junctions (TJs). Thus increasing the oral bioavailability of Pgp substrate-like drugs (PSLDs) remains a great challenge. Herein, we construct a nanocarrier system derived from Brij-grafted-chitosan (BC) to enhance the oral bioavailability and therapeutic effect of berberine (BBR, a typical PLSD) against diabetic kidney disease. The developed BC nanoparticles (BC-NPs) are demonstrated to improve the intestinal permeability of BBR via transiently and reversibly modulating the intercellular TJs (paracellular pathway) and Pgp-mediated drug efflux (transcellular pathway). As compared to free BBR and chitosan nanoparticles, the BC-NPs enhanced the relative oral bioavailability of BBR in rats (4.4- and 2.7-fold, respectively), and the therapeutic potency of BBR in renal function and histopathology. In summary, such strategy may provide an effective nanocarrier system for oral delivery of BBR and PSLDs.
Persistent Identifierhttp://hdl.handle.net/10722/306335
ISSN
2023 Impact Factor: 10.7
2023 SCImago Journal Rankings: 1.831
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorXiong, W-
dc.contributor.authorXiong, SH-
dc.contributor.authorChen, QL-
dc.contributor.authorLinghu, KG-
dc.contributor.authorZhao, GD-
dc.contributor.authorChu, JMT-
dc.contributor.authorWong, GTC-
dc.contributor.authorLi, J-
dc.contributor.authorHu, YJ-
dc.contributor.authorWang, YT-
dc.contributor.authorYu, H-
dc.date.accessioned2021-10-20T10:22:09Z-
dc.date.available2021-10-20T10:22:09Z-
dc.date.issued2021-
dc.identifier.citationCarbohydrate Polymers, 2021, v. 266, p. article no. 118112-
dc.identifier.issn0144-8617-
dc.identifier.urihttp://hdl.handle.net/10722/306335-
dc.description.abstractThe highly expressed P-glycoprotein (Pgp) in the intestine plays a key role in preventing drugs across the intestinal epithelium, which linked by tight junctions (TJs). Thus increasing the oral bioavailability of Pgp substrate-like drugs (PSLDs) remains a great challenge. Herein, we construct a nanocarrier system derived from Brij-grafted-chitosan (BC) to enhance the oral bioavailability and therapeutic effect of berberine (BBR, a typical PLSD) against diabetic kidney disease. The developed BC nanoparticles (BC-NPs) are demonstrated to improve the intestinal permeability of BBR via transiently and reversibly modulating the intercellular TJs (paracellular pathway) and Pgp-mediated drug efflux (transcellular pathway). As compared to free BBR and chitosan nanoparticles, the BC-NPs enhanced the relative oral bioavailability of BBR in rats (4.4- and 2.7-fold, respectively), and the therapeutic potency of BBR in renal function and histopathology. In summary, such strategy may provide an effective nanocarrier system for oral delivery of BBR and PSLDs.-
dc.languageeng-
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/carbpol-
dc.relation.ispartofCarbohydrate Polymers-
dc.subjectBrij-grafted-chitosan-
dc.subjectOral nanocarrier-
dc.subjectP-glycoprotein-
dc.subjectBerberine-
dc.subjectDiabetic kidney disease-
dc.titleBrij-functionalized chitosan nanocarrier system enhances the intestinal permeability of P-glycoprotein substrate-like drugs-
dc.typeArticle-
dc.identifier.emailChu, JMT: jmtchu@hku.hk-
dc.identifier.emailWong, GTC: gordon@hku.hk-
dc.identifier.authorityWong, GTC=rp00523-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.carbpol.2021.118112-
dc.identifier.pmid34044929-
dc.identifier.scopuseid_2-s2.0-85105014762-
dc.identifier.hkuros326713-
dc.identifier.volume266-
dc.identifier.spagearticle no. 118112-
dc.identifier.epagearticle no. 118112-
dc.identifier.isiWOS:000655699800006-
dc.publisher.placeUnited Kingdom-

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