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Article: Feasibility of Aerobic Exercise and Tai-Chi Interventions in Advanced Lung Cancer Patients: A Randomized Controlled Trial

TitleFeasibility of Aerobic Exercise and Tai-Chi Interventions in Advanced Lung Cancer Patients: A Randomized Controlled Trial
Authors
Keywordsadvanced cancer
lung cancer
aerobic exercise
tai-chi
survival
Issue Date2021
PublisherSAGE Publications (UK and US): Open Access Titles. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201510
Citation
Integrative Cancer Therapies, 2021, v. 20, p. article no. 153473542110333 How to Cite?
AbstractBackground: A majority of lung cancer patients are diagnosed at advanced stages. Although there is considerable evidence of the benefits of aerobic exercise and tai-chi for lung cancer patients, little is known about the comparative effectiveness of the 2 exercise modes in advanced lung cancer patients. Objectives: To explore the feasibility and preliminary effects of aerobic exercise and tai-chi interventions on survival and well-being among advanced lung cancer patients. Methods: In an assessor-blinded, exploratory randomized controlled trial, 30 advanced lung cancer patients were randomized to an aerobic exercise group, a tai-chi group (both attending 12-week, twice-weekly supervised sessions), or a self-management control group (receiving written exercise guidelines). The primary outcomes focused on feasibility including intervention completion, exercise adherence, and adverse events, while the secondary outcomes addressed preliminary effects and included 1-year survival, cancer symptoms (Pittsburgh Sleep Quality Index, Hospital Anxiety and Depression Score, Brief Fatigue Inventory), quality of life (EORTC QLQ-C30, QLQ-LC13), physical performance (6-minute walk test, up-and-go, sit-to-stand, 1-leg standing), activity levels (actigraph), and circadian rhythms (salivary cortisol). Results: Intervention feasibility was established with a satisfactory completion rate at post-intervention for the aerobic exercise group (80%) and the tai-chi group (78%). The tai-chi group attained higher adherence than the exercise group in terms of attendance in supervised sessions (89% vs 75% of scheduled classes) and self-practice (225% vs 87% of the prescribed amount). Higher adherence to self-practice in the tai-chi group remained at the 6-month follow-up (81% vs 38% of the prescribed amount). No adverse event as a result of the intervention was reported. Effect-related outcomes did not show statistically significant changes in any group, except an improvement post-intervention in the up-and-go (−2.26, 95% CI: −4.04, −0.48) and sit-to-stand tests (4.52, 95% CI: 2.19, 6.85) in the aerobic exercise group. Conclusions: The findings support the feasibility of aerobic exercise and tai-chi interventions in advanced lung cancer patients. A future study with a larger sample from multiple sites is recommended to confirm the comparative effects of the 2 exercise interventions relative to the self-management group and to enhance the generalizability of the findings.
Persistent Identifierhttp://hdl.handle.net/10722/306372
ISSN
2020 Impact Factor: 3.279
2020 SCImago Journal Rankings: 0.730
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCheung, DST-
dc.contributor.authorTakemura, N-
dc.contributor.authorLam, TC-
dc.contributor.authorHo, JCM-
dc.contributor.authorDeng, W-
dc.contributor.authorSmith, R-
dc.contributor.authorYan, Y-
dc.contributor.authorLee, AWM-
dc.contributor.authorLin, CC-
dc.date.accessioned2021-10-20T10:22:41Z-
dc.date.available2021-10-20T10:22:41Z-
dc.date.issued2021-
dc.identifier.citationIntegrative Cancer Therapies, 2021, v. 20, p. article no. 153473542110333-
dc.identifier.issn1534-7354-
dc.identifier.urihttp://hdl.handle.net/10722/306372-
dc.description.abstractBackground: A majority of lung cancer patients are diagnosed at advanced stages. Although there is considerable evidence of the benefits of aerobic exercise and tai-chi for lung cancer patients, little is known about the comparative effectiveness of the 2 exercise modes in advanced lung cancer patients. Objectives: To explore the feasibility and preliminary effects of aerobic exercise and tai-chi interventions on survival and well-being among advanced lung cancer patients. Methods: In an assessor-blinded, exploratory randomized controlled trial, 30 advanced lung cancer patients were randomized to an aerobic exercise group, a tai-chi group (both attending 12-week, twice-weekly supervised sessions), or a self-management control group (receiving written exercise guidelines). The primary outcomes focused on feasibility including intervention completion, exercise adherence, and adverse events, while the secondary outcomes addressed preliminary effects and included 1-year survival, cancer symptoms (Pittsburgh Sleep Quality Index, Hospital Anxiety and Depression Score, Brief Fatigue Inventory), quality of life (EORTC QLQ-C30, QLQ-LC13), physical performance (6-minute walk test, up-and-go, sit-to-stand, 1-leg standing), activity levels (actigraph), and circadian rhythms (salivary cortisol). Results: Intervention feasibility was established with a satisfactory completion rate at post-intervention for the aerobic exercise group (80%) and the tai-chi group (78%). The tai-chi group attained higher adherence than the exercise group in terms of attendance in supervised sessions (89% vs 75% of scheduled classes) and self-practice (225% vs 87% of the prescribed amount). Higher adherence to self-practice in the tai-chi group remained at the 6-month follow-up (81% vs 38% of the prescribed amount). No adverse event as a result of the intervention was reported. Effect-related outcomes did not show statistically significant changes in any group, except an improvement post-intervention in the up-and-go (−2.26, 95% CI: −4.04, −0.48) and sit-to-stand tests (4.52, 95% CI: 2.19, 6.85) in the aerobic exercise group. Conclusions: The findings support the feasibility of aerobic exercise and tai-chi interventions in advanced lung cancer patients. A future study with a larger sample from multiple sites is recommended to confirm the comparative effects of the 2 exercise interventions relative to the self-management group and to enhance the generalizability of the findings.-
dc.languageeng-
dc.publisherSAGE Publications (UK and US): Open Access Titles. The Journal's web site is located at http://www.sagepub.com/journalsProdDesc.nav?prodId=Journal201510-
dc.relation.ispartofIntegrative Cancer Therapies-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectadvanced cancer-
dc.subjectlung cancer-
dc.subjectaerobic exercise-
dc.subjecttai-chi-
dc.subjectsurvival-
dc.titleFeasibility of Aerobic Exercise and Tai-Chi Interventions in Advanced Lung Cancer Patients: A Randomized Controlled Trial-
dc.typeArticle-
dc.identifier.emailCheung, DST: denisest@hku.hk-
dc.identifier.emailLam, TC: lamtc03@hku.hk-
dc.identifier.emailHo, JCM: jhocm@hku.hk-
dc.identifier.emailSmith, R: robsmith@hku.hk-
dc.identifier.emailYan, Y: yxyan@hku.hk-
dc.identifier.emailLee, AWM: awmlee@hkucc.hku.hk-
dc.identifier.authorityCheung, DST=rp02526-
dc.identifier.authorityLam, TC=rp02128-
dc.identifier.authorityHo, JCM=rp00258-
dc.identifier.authorityDeng, W=rp01640-
dc.identifier.authorityLee, AWM=rp02056-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1177/15347354211033352-
dc.identifier.pmid34549648-
dc.identifier.pmcidPMC8461121-
dc.identifier.scopuseid_2-s2.0-85115433298-
dc.identifier.hkuros327586-
dc.identifier.volume20-
dc.identifier.spagearticle no. 153473542110333-
dc.identifier.epagearticle no. 153473542110333-
dc.identifier.isiWOS:000702189200001-
dc.publisher.placeUnited States-

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