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Article: Genomic characterization of a new CRF01_AE/CRF07_BC case from a MSM patient in Guangdong, China

TitleGenomic characterization of a new CRF01_AE/CRF07_BC case from a MSM patient in Guangdong, China
Authors
KeywordsChina
HIV-1
near full-length genome
recombination
the MSM population
Issue Date2021
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/32763
Citation
Journal of Medical Virology, 2021, v. 93 n. 11, p. 6383-6387 How to Cite?
AbstractThe CRF01_AE and CRF07_BC clades dominate the human immunodeficiency virus (HIV) epidemics in China. Both clades have been identified in the men who have sex with men (MSM) population in Guangdong province, raising a serious concern of possible complex recombination events ahead. Here, we report the first case of CRF01_AE/CRF07_BC recombinant sampled from a MSM patient in southern China. The genomic structure of this case is a mosaic with some regions resembling the CRF01_AE and CRF07_BC clades. Our phylogenetic analyses show that the two parental lineages of this recombinant virus were mainly found in the MSM population. This case has a different genomic composition compared with other recombinants descended from the same parental clades CRF01_AE and CRF07_BC. Our finding suggests that the MSM populations have become a hotspot for expanding viral diversity through the viral recombination mechanism. Therefore, further epidemiologic surveillance and monitoring should be conducted within the MSM populations to help advance our knowledge of viral transmission mechanisms. Additionally, these measures will serve to enhance the control and prevention of HIV/acquired immunodeficiency syndrome in China.
Persistent Identifierhttp://hdl.handle.net/10722/306430
ISSN
2020 Impact Factor: 2.327
2020 SCImago Journal Rankings: 0.782
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHuang, XH-
dc.contributor.authorYu, G-
dc.contributor.authorZheng, C-
dc.contributor.authorZhou, PP-
dc.contributor.authorAnderson, C-
dc.contributor.authorZhao, J-
dc.contributor.authorLam, TTY-
dc.contributor.authorLi, Y-
dc.contributor.authorChen, L-
dc.contributor.authorLin, P-
dc.contributor.authorZhang, M-
dc.contributor.authorYan, J-
dc.contributor.authorHe, X-
dc.date.accessioned2021-10-22T07:34:30Z-
dc.date.available2021-10-22T07:34:30Z-
dc.date.issued2021-
dc.identifier.citationJournal of Medical Virology, 2021, v. 93 n. 11, p. 6383-6387-
dc.identifier.issn0146-6615-
dc.identifier.urihttp://hdl.handle.net/10722/306430-
dc.description.abstractThe CRF01_AE and CRF07_BC clades dominate the human immunodeficiency virus (HIV) epidemics in China. Both clades have been identified in the men who have sex with men (MSM) population in Guangdong province, raising a serious concern of possible complex recombination events ahead. Here, we report the first case of CRF01_AE/CRF07_BC recombinant sampled from a MSM patient in southern China. The genomic structure of this case is a mosaic with some regions resembling the CRF01_AE and CRF07_BC clades. Our phylogenetic analyses show that the two parental lineages of this recombinant virus were mainly found in the MSM population. This case has a different genomic composition compared with other recombinants descended from the same parental clades CRF01_AE and CRF07_BC. Our finding suggests that the MSM populations have become a hotspot for expanding viral diversity through the viral recombination mechanism. Therefore, further epidemiologic surveillance and monitoring should be conducted within the MSM populations to help advance our knowledge of viral transmission mechanisms. Additionally, these measures will serve to enhance the control and prevention of HIV/acquired immunodeficiency syndrome in China.-
dc.languageeng-
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/32763-
dc.relation.ispartofJournal of Medical Virology-
dc.rightsSubmitted (preprint) Version This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Accepted (peer-reviewed) Version This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.-
dc.subjectChina-
dc.subjectHIV-1-
dc.subjectnear full-length genome-
dc.subjectrecombination-
dc.subjectthe MSM population-
dc.titleGenomic characterization of a new CRF01_AE/CRF07_BC case from a MSM patient in Guangdong, China-
dc.typeArticle-
dc.identifier.emailLam, TTY: ttylam@hku.hk-
dc.identifier.authorityLam, TTY=rp01733-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/jmv.26799-
dc.identifier.pmid33448453-
dc.identifier.scopuseid_2-s2.0-85099917271-
dc.identifier.hkuros329128-
dc.identifier.volume93-
dc.identifier.issue11-
dc.identifier.spage6383-
dc.identifier.epage6387-
dc.identifier.isiWOS:000612182600001-
dc.publisher.placeUnited States-

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