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Article: Epigenetics and Inflammation in Diabetic Nephropathy

TitleEpigenetics and Inflammation in Diabetic Nephropathy
Authors
Keywordsdiabetic nephropathy
epigenetics
DNA methylation
histone modifications
non-coding RNAs
Issue Date2021
PublisherFrontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/physiology/
Citation
Frontiers in Physiology, 2021, v. 12, p. article no. 649587 How to Cite?
AbstractDiabetic nephropathy (DN) leads to high morbidity and disability. Inflammation plays a critical role in the pathogenesis of DN, which involves renal cells and immune cells, the microenvironment, as well as extrinsic factors, such as hyperglycemia, chemokines, cytokines, and growth factors. Epigenetic modifications usually regulate gene expression via DNA methylation, histone modification, and non-coding RNAs without altering the DNA sequence. During the past years, numerous studies have been published to reveal the mechanisms of epigenetic modifications that regulate inflammation in DN. This review aimed to summarize the latest evidence on the interplay of epigenetics and inflammation in DN, and highlight the potential targets for treatment and diagnosis of DN.
Persistent Identifierhttp://hdl.handle.net/10722/306588
ISSN
2021 Impact Factor: 4.755
2020 SCImago Journal Rankings: 1.320
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSHAO, BY-
dc.contributor.authorZhang, SF-
dc.contributor.authorLi, HD-
dc.contributor.authorMeng, XM-
dc.contributor.authorChen, HY-
dc.date.accessioned2021-10-22T07:36:47Z-
dc.date.available2021-10-22T07:36:47Z-
dc.date.issued2021-
dc.identifier.citationFrontiers in Physiology, 2021, v. 12, p. article no. 649587-
dc.identifier.issn1664-042X-
dc.identifier.urihttp://hdl.handle.net/10722/306588-
dc.description.abstractDiabetic nephropathy (DN) leads to high morbidity and disability. Inflammation plays a critical role in the pathogenesis of DN, which involves renal cells and immune cells, the microenvironment, as well as extrinsic factors, such as hyperglycemia, chemokines, cytokines, and growth factors. Epigenetic modifications usually regulate gene expression via DNA methylation, histone modification, and non-coding RNAs without altering the DNA sequence. During the past years, numerous studies have been published to reveal the mechanisms of epigenetic modifications that regulate inflammation in DN. This review aimed to summarize the latest evidence on the interplay of epigenetics and inflammation in DN, and highlight the potential targets for treatment and diagnosis of DN.-
dc.languageeng-
dc.publisherFrontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/physiology/-
dc.relation.ispartofFrontiers in Physiology-
dc.rightsThis Document is Protected by copyright and was first published by Frontiers. All rights reserved. It is reproduced with permission.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectdiabetic nephropathy-
dc.subjectepigenetics-
dc.subjectDNA methylation-
dc.subjecthistone modifications-
dc.subjectnon-coding RNAs-
dc.titleEpigenetics and Inflammation in Diabetic Nephropathy-
dc.typeArticle-
dc.identifier.emailLi, HD: lihaidi@hku.hk-
dc.identifier.emailChen, HY: haiyong@hku.hk-
dc.identifier.authorityChen, HY=rp01923-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3389/fphys.2021.649587-
dc.identifier.pmid34025445-
dc.identifier.pmcidPMC8131683-
dc.identifier.scopuseid_2-s2.0-85106048967-
dc.identifier.hkuros328872-
dc.identifier.volume12-
dc.identifier.spagearticle no. 649587-
dc.identifier.epagearticle no. 649587-
dc.identifier.isiWOS:000651760100001-
dc.publisher.placeSwitzerland-

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