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Article: Associations of sleep phenotypes with severe intentional self-harm: a prospective analysis of the UK Biobank cohort

TitleAssociations of sleep phenotypes with severe intentional self-harm: a prospective analysis of the UK Biobank cohort
Authors
Keywordssleep phenotypes
intentional self-harm
UK Biobank
Issue Date2021
PublisherOxford University Press. The Journal's web site is located at http://www.journalsleep.org
Citation
Sleep, 2021, v. 44 n. 8, p. article no. zsab053 How to Cite?
AbstractStudy objectives: We aimed to investigate the prospective associations of sleep phenotypes with severe intentional self-harm (ISH) in middle-aged and older adults. Methods: A total of 499,159 participants (mean age: 56.55 ± 8.09 years; female: 54.4%) were recruited from the UK Biobank between 2006 and 2010 with follow-up until February 2016 in this population-based prospective study. Severe ISH was based on hospital inpatient records or a death cause of ICD-10 codes X60-X84. Patients with hospitalized diagnosis of severe ISH before the initial assessment were excluded. Sleep phenotypes, including sleep duration, chronotype, insomnia, sleepiness, and napping, were assessed at the initial assessments. Cox regression analysis was used to estimate temporal associations between sleep phenotypes and future risk of severe ISH. Results: During a follow-up period of 7.04 years (SD: 0.88), 1,219 participants experienced the first hospitalization or death related to severe ISH. After adjusting for demographics, substance use, medical diseases, mental disorders, and other sleep phenotypes, short sleep duration (HR: 1.50, 95% CI: 1.23–1.83, p < .001), long sleep duration (HR: 1.56, 95% CI: 1.15–2.12, p = .004), and insomnia (usually: HR: 1.57, 95% CI: 1.31–1.89, p < .001) were significantly associated with severe ISH. Sensitivity analyses excluding participants with mental disorders preceding severe ISH yielded similar results. Conclusion: The current study provides the empirical evidence of the independent prediction of sleep phenotypes, mainly insomnia, short- and long-sleep duration, for the future risk of severe ISH among middle-aged and older adults.
Persistent Identifierhttp://hdl.handle.net/10722/306648
ISSN
2023 Impact Factor: 5.3
2023 SCImago Journal Rankings: 1.717
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLei, B-
dc.contributor.authorZhang, J-
dc.contributor.authorChen, S-
dc.contributor.authorChen, J-
dc.contributor.authorYang, L-
dc.contributor.authorAi, S-
dc.contributor.authorChan, NY-
dc.contributor.authorWang, J-
dc.contributor.authorDai, XJ-
dc.contributor.authorFeng, H-
dc.contributor.authorLiu, Y-
dc.contributor.authorLi, SX-
dc.contributor.authorJia, F-
dc.contributor.authorWing, YK-
dc.date.accessioned2021-10-22T07:37:38Z-
dc.date.available2021-10-22T07:37:38Z-
dc.date.issued2021-
dc.identifier.citationSleep, 2021, v. 44 n. 8, p. article no. zsab053-
dc.identifier.issn0161-8105-
dc.identifier.urihttp://hdl.handle.net/10722/306648-
dc.description.abstractStudy objectives: We aimed to investigate the prospective associations of sleep phenotypes with severe intentional self-harm (ISH) in middle-aged and older adults. Methods: A total of 499,159 participants (mean age: 56.55 ± 8.09 years; female: 54.4%) were recruited from the UK Biobank between 2006 and 2010 with follow-up until February 2016 in this population-based prospective study. Severe ISH was based on hospital inpatient records or a death cause of ICD-10 codes X60-X84. Patients with hospitalized diagnosis of severe ISH before the initial assessment were excluded. Sleep phenotypes, including sleep duration, chronotype, insomnia, sleepiness, and napping, were assessed at the initial assessments. Cox regression analysis was used to estimate temporal associations between sleep phenotypes and future risk of severe ISH. Results: During a follow-up period of 7.04 years (SD: 0.88), 1,219 participants experienced the first hospitalization or death related to severe ISH. After adjusting for demographics, substance use, medical diseases, mental disorders, and other sleep phenotypes, short sleep duration (HR: 1.50, 95% CI: 1.23–1.83, p < .001), long sleep duration (HR: 1.56, 95% CI: 1.15–2.12, p = .004), and insomnia (usually: HR: 1.57, 95% CI: 1.31–1.89, p < .001) were significantly associated with severe ISH. Sensitivity analyses excluding participants with mental disorders preceding severe ISH yielded similar results. Conclusion: The current study provides the empirical evidence of the independent prediction of sleep phenotypes, mainly insomnia, short- and long-sleep duration, for the future risk of severe ISH among middle-aged and older adults.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://www.journalsleep.org-
dc.relation.ispartofSleep-
dc.rightsPost-print: This is a pre-copy-editing, author-produced PDF of an article accepted for publication in [insert journal title] following peer review. The definitive publisher-authenticated version [insert complete citation information here] is available online at: xxxxxxx [insert URL that the author will receive upon publication here].-
dc.subjectsleep phenotypes-
dc.subjectintentional self-harm-
dc.subjectUK Biobank-
dc.titleAssociations of sleep phenotypes with severe intentional self-harm: a prospective analysis of the UK Biobank cohort-
dc.typeArticle-
dc.identifier.emailLi, SX: shirleyx@hku.hk-
dc.identifier.authorityLi, SX=rp02114-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1093/sleep/zsab053-
dc.identifier.pmid33640972-
dc.identifier.scopuseid_2-s2.0-85114381693-
dc.identifier.hkuros328790-
dc.identifier.volume44-
dc.identifier.issue8-
dc.identifier.spagearticle no. zsab053-
dc.identifier.epagearticle no. zsab053-
dc.identifier.isiWOS:000692616900013-
dc.publisher.placeUnited States-

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