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Article: Recommendations by the Asian Pacific society of nephrology (APSN) on the appropriate use of HIF‐PH inhibitors

TitleRecommendations by the Asian Pacific society of nephrology (APSN) on the appropriate use of HIF‐PH inhibitors
Authors
Issue Date2021
PublisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1440-1797
Citation
Nephrology, 2021, v. 26 n. 2, p. 105-118 How to Cite?
AbstractRenal anaemia is a common and important complication in patients with chronic kidney disease (CKD). The current standard-of-care treatment for renal anaemia in CKD patients involves ensuring adequate iron stores and administration of erythropoietin stimulating agents (ESA). Hypoxia inducible factor (HIF) is a key transcription factor primarily involved in the cellular regulation and efficiency of oxygen delivery. Manipulation of the HIF pathway by the use of HIF-prolyl hydroxylase inhibitors (HIF-PHI) has emerged as a novel approach for renal anaemia management. Despite it being approved for clinical use in various Asia-Pacific countries, its novelty mandates the need for nephrologists and clinicians generally in the region to well understand potential benefits and harms when prescribing this class of drug. The Asian Pacific society of nephrology HIF-PHI Recommendation Committee, formed by a panel of 11 nephrologists from the Asia-Pacific region who have clinical experience or have been investigators in HIF-PHI studies, reviewed and deliberated on the clinical and preclinical data concerning HIF-PHI. This recommendation summarizes the consensus views of the committee regarding the use of HIF-PHI, taking into account both available data and expert opinion in areas where evidence remains scarce.
Persistent Identifierhttp://hdl.handle.net/10722/306713
ISSN
2023 Impact Factor: 2.4
2023 SCImago Journal Rankings: 0.641
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYap, DYH-
dc.contributor.authorMcMahon, LP-
dc.contributor.authorHao, CM-
dc.contributor.authorHu, N-
dc.contributor.authorOkada, H-
dc.contributor.authorSuzuki, Y-
dc.contributor.authorKim, SG-
dc.contributor.authorLim, SK-
dc.contributor.authorVareesangthip, K-
dc.contributor.authorHung, CC-
dc.contributor.authorNangaku, M-
dc.date.accessioned2021-10-22T07:38:32Z-
dc.date.available2021-10-22T07:38:32Z-
dc.date.issued2021-
dc.identifier.citationNephrology, 2021, v. 26 n. 2, p. 105-118-
dc.identifier.issn1320-5358-
dc.identifier.urihttp://hdl.handle.net/10722/306713-
dc.description.abstractRenal anaemia is a common and important complication in patients with chronic kidney disease (CKD). The current standard-of-care treatment for renal anaemia in CKD patients involves ensuring adequate iron stores and administration of erythropoietin stimulating agents (ESA). Hypoxia inducible factor (HIF) is a key transcription factor primarily involved in the cellular regulation and efficiency of oxygen delivery. Manipulation of the HIF pathway by the use of HIF-prolyl hydroxylase inhibitors (HIF-PHI) has emerged as a novel approach for renal anaemia management. Despite it being approved for clinical use in various Asia-Pacific countries, its novelty mandates the need for nephrologists and clinicians generally in the region to well understand potential benefits and harms when prescribing this class of drug. The Asian Pacific society of nephrology HIF-PHI Recommendation Committee, formed by a panel of 11 nephrologists from the Asia-Pacific region who have clinical experience or have been investigators in HIF-PHI studies, reviewed and deliberated on the clinical and preclinical data concerning HIF-PHI. This recommendation summarizes the consensus views of the committee regarding the use of HIF-PHI, taking into account both available data and expert opinion in areas where evidence remains scarce.-
dc.languageeng-
dc.publisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1440-1797-
dc.relation.ispartofNephrology-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleRecommendations by the Asian Pacific society of nephrology (APSN) on the appropriate use of HIF‐PH inhibitors-
dc.typeArticle-
dc.identifier.emailYap, DYH: desmondy@hku.hk-
dc.identifier.authorityYap, DYH=rp01607-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1111/nep.13835-
dc.identifier.pmid3222343-
dc.identifier.pmcidPMC7898910-
dc.identifier.scopuseid_2-s2.0-85097306486-
dc.identifier.hkuros328672-
dc.identifier.volume26-
dc.identifier.issue2-
dc.identifier.spage105-
dc.identifier.epage118-
dc.identifier.isiWOS:000596785500001-
dc.publisher.placeAustralia-

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