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Article: Liver Abscess in Chronic Granulomatous Disease—Two Decades of Experience from a Tertiary Care Centre in North-West India

TitleLiver Abscess in Chronic Granulomatous Disease—Two Decades of Experience from a Tertiary Care Centre in North-West India
Authors
KeywordsChronic granulomatous disease
liver abscess
corticosteroids
primary immunodeficiency disorder
Issue Date2021
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0271-9142
Citation
Journal of Clinical Immunology, 2021, v. 41 n. 3, p. 552-564 How to Cite?
AbstractPurpose: Most of the literature on liver abscess in chronic granulomatous disease (CGD) emanates from developed countries. Data from developing countries are scarce. In this study, we report clinical features, microbiological profile, and treatment difficulties encountered while managing liver abscesses in patients with CGD at a tertiary care centre in North-West India. Methodology: Case records of children with CGD and liver abscesses at Pediatric Immunodeficiency Clinic, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India were analyzed. Results: Seven of 68 patients (10.29%) with CGD presented with hepatic abscess. One patient had 2 recurrences. All were males and age-range at presentation was 7 months–22 years. Mutation analysis was carried out in all patients—3 had defects in CYBB gene; 2 in NCF1; 2 in NCF2 gene. Staphylococcus aureus was isolated from 5 patients. Duration of antimicrobial treatment ranged from 3 weeks to 7 months. Open drainage was required in 1 patient, and 1 patient was treated with a prolonged course of prednisolone. Two children succumbed to the illness. Conclusions: This is the largest reported experience of liver abscesses in patients with CGD from the developing world. Staphylococcus aureus was the commonest pathogen isolated. In our experience, prolonged courses of antimicrobials are usually necessary in these patients. Glucocorticoids can reduce inflammatory response and facilitate early resolution of abscesses in CGD.
Persistent Identifierhttp://hdl.handle.net/10722/306723
ISSN
2023 Impact Factor: 7.2
2023 SCImago Journal Rankings: 2.258
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorPilania, RK-
dc.contributor.authorRawat, A-
dc.contributor.authorVignesh, P-
dc.contributor.authorGuleria, S-
dc.contributor.authorJindal, AK-
dc.contributor.authorDas, G-
dc.contributor.authorSuri, D-
dc.contributor.authorGupta, A-
dc.contributor.authorGupta, K-
dc.contributor.authorChan, KW-
dc.contributor.authorLau, YL-
dc.contributor.authorImai, K-
dc.contributor.authorSingh, S-
dc.date.accessioned2021-10-22T07:38:40Z-
dc.date.available2021-10-22T07:38:40Z-
dc.date.issued2021-
dc.identifier.citationJournal of Clinical Immunology, 2021, v. 41 n. 3, p. 552-564-
dc.identifier.issn0271-9142-
dc.identifier.urihttp://hdl.handle.net/10722/306723-
dc.description.abstractPurpose: Most of the literature on liver abscess in chronic granulomatous disease (CGD) emanates from developed countries. Data from developing countries are scarce. In this study, we report clinical features, microbiological profile, and treatment difficulties encountered while managing liver abscesses in patients with CGD at a tertiary care centre in North-West India. Methodology: Case records of children with CGD and liver abscesses at Pediatric Immunodeficiency Clinic, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India were analyzed. Results: Seven of 68 patients (10.29%) with CGD presented with hepatic abscess. One patient had 2 recurrences. All were males and age-range at presentation was 7 months–22 years. Mutation analysis was carried out in all patients—3 had defects in CYBB gene; 2 in NCF1; 2 in NCF2 gene. Staphylococcus aureus was isolated from 5 patients. Duration of antimicrobial treatment ranged from 3 weeks to 7 months. Open drainage was required in 1 patient, and 1 patient was treated with a prolonged course of prednisolone. Two children succumbed to the illness. Conclusions: This is the largest reported experience of liver abscesses in patients with CGD from the developing world. Staphylococcus aureus was the commonest pathogen isolated. In our experience, prolonged courses of antimicrobials are usually necessary in these patients. Glucocorticoids can reduce inflammatory response and facilitate early resolution of abscesses in CGD.-
dc.languageeng-
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0271-9142-
dc.relation.ispartofJournal of Clinical Immunology-
dc.rightsThis is a post-peer-review, pre-copyedit version of an article published in [insert journal title]. The final authenticated version is available online at: https://doi.org/[insert DOI]-
dc.subjectChronic granulomatous disease-
dc.subjectliver abscess-
dc.subjectcorticosteroids-
dc.subjectprimary immunodeficiency disorder-
dc.titleLiver Abscess in Chronic Granulomatous Disease—Two Decades of Experience from a Tertiary Care Centre in North-West India-
dc.typeArticle-
dc.identifier.emailChan, KW: kwchan@hku.hk-
dc.identifier.emailLau, YL: lauylung@hku.hk-
dc.identifier.authorityLau, YL=rp00361-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s10875-020-00938-9-
dc.identifier.pmid33387158-
dc.identifier.scopuseid_2-s2.0-85098597874-
dc.identifier.hkuros328635-
dc.identifier.volume41-
dc.identifier.issue3-
dc.identifier.spage552-
dc.identifier.epage564-
dc.identifier.isiWOS:000604158200003-
dc.publisher.placeUnited States-

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