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- Publisher Website: 10.1016/j.atherosclerosis.2010.12.012
- Scopus: eid_2-s2.0-79952102135
- PMID: 21227420
- WOS: WOS:000288008700035
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Article: Socioeconomic and ethnic differences in use of lipid-lowering drugs after deregulation of simvastatin in the UK: The Whitehall II prospective cohort study
Title | Socioeconomic and ethnic differences in use of lipid-lowering drugs after deregulation of simvastatin in the UK: The Whitehall II prospective cohort study |
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Authors | |
Keywords | Inequalities Pharmacoepidemiology Socioeconomic position Ethnicity Cardiovascular risk Statin |
Issue Date | 2011 |
Citation | Atherosclerosis, 2011, v. 215, n. 1, p. 223-228 How to Cite? |
Abstract | Background: We examined socioeconomic and ethnic differences in use of lipid-lowering drugs after deregulation of simvastatin in the UK for adults with moderate or high risk of coronary heart disease. Methods: 3631 participants in the Whitehall II cohort study (mean age 62.7. years, 91% white) were informed of their risk of coronary heart disease, based on Framingham score, before deregulation (2002-2004). The use of prescribed lipid-lowering drugs and use of over-the-counter simvastatin were analysed as outcome variables, after deregulation (2005-2007). Results: 2451 participants were at high risk and 1180 at moderate risk. 20% moderate-risk and 44% high-risk participants reported using prescribed lipid-lowering drugs although no over-the-counter simvastatin was used. Prescribing rates did not differ between employment grades (an index of socioeconomic position), but was higher among South Asian high-risk compared with White high-risk participants (odds ratio 1.64, 95% CI 1.21-2.23). Of the high-risk participants, 44% recalled their increased coronary heart disease risk. South Asian high-risk participants were less likely to recall than White high-risk participants (odds ratio 0.65, 95% CI 0.46-0.93). Furthermore, high risk participants with middle (odds ratio 0.74, 95% CI 0.61-0.89) and low (odds ratio 0.52, 95% CI 0.37-0.74) employment grades were less likely to recall than those with high grades. Conclusion: Socioeconomic and ethnic differences in reported use of lipid-lowering drugs were small, but the use of these drugs in general was much lower than recommended and the participants did not utilise over-the-counter statins. Ethnic minorities and lower socioeconomic position groups were less likely to be aware of their increased coronary risk. © 2010 Elsevier Ireland Ltd. |
Persistent Identifier | http://hdl.handle.net/10722/307104 |
ISSN | 2023 Impact Factor: 4.9 2023 SCImago Journal Rankings: 1.461 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Forde, Ian | - |
dc.contributor.author | Chandola, Tarani | - |
dc.contributor.author | Raine, Rosalind | - |
dc.contributor.author | Marmot, Michael G. | - |
dc.contributor.author | Kivimaki, Mika | - |
dc.date.accessioned | 2021-11-03T06:21:56Z | - |
dc.date.available | 2021-11-03T06:21:56Z | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | Atherosclerosis, 2011, v. 215, n. 1, p. 223-228 | - |
dc.identifier.issn | 0021-9150 | - |
dc.identifier.uri | http://hdl.handle.net/10722/307104 | - |
dc.description.abstract | Background: We examined socioeconomic and ethnic differences in use of lipid-lowering drugs after deregulation of simvastatin in the UK for adults with moderate or high risk of coronary heart disease. Methods: 3631 participants in the Whitehall II cohort study (mean age 62.7. years, 91% white) were informed of their risk of coronary heart disease, based on Framingham score, before deregulation (2002-2004). The use of prescribed lipid-lowering drugs and use of over-the-counter simvastatin were analysed as outcome variables, after deregulation (2005-2007). Results: 2451 participants were at high risk and 1180 at moderate risk. 20% moderate-risk and 44% high-risk participants reported using prescribed lipid-lowering drugs although no over-the-counter simvastatin was used. Prescribing rates did not differ between employment grades (an index of socioeconomic position), but was higher among South Asian high-risk compared with White high-risk participants (odds ratio 1.64, 95% CI 1.21-2.23). Of the high-risk participants, 44% recalled their increased coronary heart disease risk. South Asian high-risk participants were less likely to recall than White high-risk participants (odds ratio 0.65, 95% CI 0.46-0.93). Furthermore, high risk participants with middle (odds ratio 0.74, 95% CI 0.61-0.89) and low (odds ratio 0.52, 95% CI 0.37-0.74) employment grades were less likely to recall than those with high grades. Conclusion: Socioeconomic and ethnic differences in reported use of lipid-lowering drugs were small, but the use of these drugs in general was much lower than recommended and the participants did not utilise over-the-counter statins. Ethnic minorities and lower socioeconomic position groups were less likely to be aware of their increased coronary risk. © 2010 Elsevier Ireland Ltd. | - |
dc.language | eng | - |
dc.relation.ispartof | Atherosclerosis | - |
dc.subject | Inequalities | - |
dc.subject | Pharmacoepidemiology | - |
dc.subject | Socioeconomic position | - |
dc.subject | Ethnicity | - |
dc.subject | Cardiovascular risk | - |
dc.subject | Statin | - |
dc.title | Socioeconomic and ethnic differences in use of lipid-lowering drugs after deregulation of simvastatin in the UK: The Whitehall II prospective cohort study | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1016/j.atherosclerosis.2010.12.012 | - |
dc.identifier.pmid | 21227420 | - |
dc.identifier.pmcid | PMC3249398 | - |
dc.identifier.scopus | eid_2-s2.0-79952102135 | - |
dc.identifier.volume | 215 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 223 | - |
dc.identifier.epage | 228 | - |
dc.identifier.isi | WOS:000288008700035 | - |