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Article: Collagen–Alginate Composite Hydrogel: Application in Tissue Engineering and Biomedical Sciences

TitleCollagen–Alginate Composite Hydrogel: Application in Tissue Engineering and Biomedical Sciences
Authors
Keywordscollagen–alginate composite hydrogel
tissue regeneration
wound dressing
tissue engineering
encapsulated cell therapy
Issue Date2021
PublisherMDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/polymers
Citation
Polymers, 2021, v. 13 n. 11, p. article no. 1852 How to Cite?
AbstractAlginate (ALG), a polysaccharide derived from brown seaweed, has been extensively investigated as a biomaterial not only in tissue engineering but also for numerous biomedical sciences owing to its wide availability, good compatibility, weak cytotoxicity, low cost, and ease of gelation. Nevertheless, alginate lacks cell-binding sites, limiting long-term cell survival and viability in 3D culture. Collagen (Col), a major component protein found in the extracellular matrix (ECM), exhibits excellent biocompatibility and weak immunogenicity. Furthermore, collagen contains cell-binding motifs, which facilitate cell attachment, interaction, and spreading, consequently maintaining cell viability and promoting cell proliferation. Recently, there has been a growing body of investigations into collagen-based hydrogel trying to overcome the poor mechanical properties of collagen. In particular, collagen–alginate composite (CAC) hydrogel has attracted much attention due to its excellent biocompatibility, gelling under mild conditions, low cytotoxicity, controllable mechanic properties, wider availability as well as ease of incorporation of other biomaterials and bioactive agents. This review aims to provide an overview of the properties of alginate and collagen. Moreover, the application of CAC hydrogel in tissue engineering and biomedical sciences is also discussed.
Persistent Identifierhttp://hdl.handle.net/10722/307599
ISSN
2023 Impact Factor: 4.7
2023 SCImago Journal Rankings: 0.800
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHU, T-
dc.contributor.authorLo, ACY-
dc.date.accessioned2021-11-12T13:34:57Z-
dc.date.available2021-11-12T13:34:57Z-
dc.date.issued2021-
dc.identifier.citationPolymers, 2021, v. 13 n. 11, p. article no. 1852-
dc.identifier.issn2073-4360-
dc.identifier.urihttp://hdl.handle.net/10722/307599-
dc.description.abstractAlginate (ALG), a polysaccharide derived from brown seaweed, has been extensively investigated as a biomaterial not only in tissue engineering but also for numerous biomedical sciences owing to its wide availability, good compatibility, weak cytotoxicity, low cost, and ease of gelation. Nevertheless, alginate lacks cell-binding sites, limiting long-term cell survival and viability in 3D culture. Collagen (Col), a major component protein found in the extracellular matrix (ECM), exhibits excellent biocompatibility and weak immunogenicity. Furthermore, collagen contains cell-binding motifs, which facilitate cell attachment, interaction, and spreading, consequently maintaining cell viability and promoting cell proliferation. Recently, there has been a growing body of investigations into collagen-based hydrogel trying to overcome the poor mechanical properties of collagen. In particular, collagen–alginate composite (CAC) hydrogel has attracted much attention due to its excellent biocompatibility, gelling under mild conditions, low cytotoxicity, controllable mechanic properties, wider availability as well as ease of incorporation of other biomaterials and bioactive agents. This review aims to provide an overview of the properties of alginate and collagen. Moreover, the application of CAC hydrogel in tissue engineering and biomedical sciences is also discussed.-
dc.languageeng-
dc.publisherMDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/polymers-
dc.relation.ispartofPolymers-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectcollagen–alginate composite hydrogel-
dc.subjecttissue regeneration-
dc.subjectwound dressing-
dc.subjecttissue engineering-
dc.subjectencapsulated cell therapy-
dc.titleCollagen–Alginate Composite Hydrogel: Application in Tissue Engineering and Biomedical Sciences-
dc.typeArticle-
dc.identifier.emailLo, ACY: amylo@hku.hk-
dc.identifier.authorityLo, ACY=rp00425-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3390/polym13111852-
dc.identifier.pmid34199641-
dc.identifier.pmcidPMC8199729-
dc.identifier.scopuseid_2-s2.0-85108182898-
dc.identifier.hkuros329656-
dc.identifier.volume13-
dc.identifier.issue11-
dc.identifier.spagearticle no. 1852-
dc.identifier.epagearticle no. 1852-
dc.identifier.isiWOS:000660540200001-
dc.publisher.placeSwitzerland-

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