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- Publisher Website: 10.3390/cells10112876
- Scopus: eid_2-s2.0-85117613647
- PMID: 34831099
- WOS: WOS:000727537900001
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Article: Single-Cell Approaches to Deconvolute the Development of HSCs
Title | Single-Cell Approaches to Deconvolute the Development of HSCs |
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Authors | |
Keywords | HSC single-cell technology molecular barcode spatial transcriptomics |
Issue Date | 2021 |
Publisher | MDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/cells |
Citation | Cells, 2021, v. 10 n. 11, p. article no. 2876 How to Cite? |
Abstract | Hematopoietic stem cells (HSCs) play a core role in blood development. The ability to efficiently produce HSCs from various pluripotent stem cell sources is the Holy Grail in the hematology field. However, in vitro or in vivo HSC production remains low, which may be attributable to the lack of understanding of hematopoiesis. Here, we review the recent progress in this area and introduce advanced technologies, such as single-cell RNA-seq, spatial transcriptomics, and molecular barcoding, which may help to acquire missing information about HSC generation. We finally discuss unresolved questions, the answers to which may be conducive to HSC production, providing a promising path toward HSC-based immunotherapies. |
Persistent Identifier | http://hdl.handle.net/10722/307605 |
ISSN | 2023 Impact Factor: 5.1 2023 SCImago Journal Rankings: 1.547 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | XIANG, Y | - |
dc.contributor.author | Sugimura, R | - |
dc.date.accessioned | 2021-11-12T13:35:03Z | - |
dc.date.available | 2021-11-12T13:35:03Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Cells, 2021, v. 10 n. 11, p. article no. 2876 | - |
dc.identifier.issn | 2073-4409 | - |
dc.identifier.uri | http://hdl.handle.net/10722/307605 | - |
dc.description.abstract | Hematopoietic stem cells (HSCs) play a core role in blood development. The ability to efficiently produce HSCs from various pluripotent stem cell sources is the Holy Grail in the hematology field. However, in vitro or in vivo HSC production remains low, which may be attributable to the lack of understanding of hematopoiesis. Here, we review the recent progress in this area and introduce advanced technologies, such as single-cell RNA-seq, spatial transcriptomics, and molecular barcoding, which may help to acquire missing information about HSC generation. We finally discuss unresolved questions, the answers to which may be conducive to HSC production, providing a promising path toward HSC-based immunotherapies. | - |
dc.language | eng | - |
dc.publisher | MDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/cells | - |
dc.relation.ispartof | Cells | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | HSC | - |
dc.subject | single-cell technology | - |
dc.subject | molecular barcode | - |
dc.subject | spatial transcriptomics | - |
dc.title | Single-Cell Approaches to Deconvolute the Development of HSCs | - |
dc.type | Article | - |
dc.identifier.email | Sugimura, R: rios@hku.hk | - |
dc.identifier.authority | Sugimura, R=rp02766 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.3390/cells10112876 | - |
dc.identifier.pmid | 34831099 | - |
dc.identifier.pmcid | PMC8616492 | - |
dc.identifier.scopus | eid_2-s2.0-85117613647 | - |
dc.identifier.hkuros | 329637 | - |
dc.identifier.volume | 10 | - |
dc.identifier.issue | 11 | - |
dc.identifier.spage | article no. 2876 | - |
dc.identifier.epage | article no. 2876 | - |
dc.identifier.isi | WOS:000727537900001 | - |
dc.publisher.place | Switzerland | - |