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Article: Non-union bone fractures

TitleNon-union bone fractures
Authors
Issue Date2021
PublisherNature Research: Nature Reviews Journals. The Journal's web site is located at http://www.nature.com/nrdp/
Citation
Nature Reviews Disease Primers, 2021, v. 7 n. 1, p. article no. 57 How to Cite?
AbstractThe human skeleton has remarkable regenerative properties, being one of the few structures in the body that can heal by recreating its normal cellular composition, orientation and mechanical strength. When the healing process of a fractured bone fails owing to inadequate immobilization, failed surgical intervention, insufficient biological response or infection, the outcome after a prolonged period of no healing is defined as non-union. Non-union represents a chronic medical condition not only affecting function but also potentially impacting the individual’s psychosocial and economic well-being. This Primer provides the reader with an in-depth understanding of our contemporary knowledge regarding the important features to be considered when faced with non-union. The normal mechanisms involved in bone healing and the factors that disrupt the normal signalling mechanisms are addressed. Epidemiological considerations and advances in the diagnosis and surgical therapy of non-union are highlighted and the need for greater efforts in basic, translational and clinical research are identified.
Persistent Identifierhttp://hdl.handle.net/10722/307640
ISSN
2023 Impact Factor: 76.9
2023 SCImago Journal Rankings: 10.215
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWildemann, B-
dc.contributor.authorIgnatius, A-
dc.contributor.authorLeung, F-
dc.contributor.authorTaitsman, LA-
dc.contributor.authorSmith, RM-
dc.contributor.authorPesantez, R-
dc.contributor.authorStoddart, MJ-
dc.contributor.authorRichards, RG-
dc.contributor.authorJupiter, JB-
dc.date.accessioned2021-11-12T13:35:37Z-
dc.date.available2021-11-12T13:35:37Z-
dc.date.issued2021-
dc.identifier.citationNature Reviews Disease Primers, 2021, v. 7 n. 1, p. article no. 57-
dc.identifier.issn2056-676X-
dc.identifier.urihttp://hdl.handle.net/10722/307640-
dc.description.abstractThe human skeleton has remarkable regenerative properties, being one of the few structures in the body that can heal by recreating its normal cellular composition, orientation and mechanical strength. When the healing process of a fractured bone fails owing to inadequate immobilization, failed surgical intervention, insufficient biological response or infection, the outcome after a prolonged period of no healing is defined as non-union. Non-union represents a chronic medical condition not only affecting function but also potentially impacting the individual’s psychosocial and economic well-being. This Primer provides the reader with an in-depth understanding of our contemporary knowledge regarding the important features to be considered when faced with non-union. The normal mechanisms involved in bone healing and the factors that disrupt the normal signalling mechanisms are addressed. Epidemiological considerations and advances in the diagnosis and surgical therapy of non-union are highlighted and the need for greater efforts in basic, translational and clinical research are identified.-
dc.languageeng-
dc.publisherNature Research: Nature Reviews Journals. The Journal's web site is located at http://www.nature.com/nrdp/-
dc.relation.ispartofNature Reviews Disease Primers-
dc.titleNon-union bone fractures-
dc.typeArticle-
dc.identifier.emailLeung, F: klleunga@hkucc.hku.hk-
dc.identifier.authorityLeung, F=rp00297-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/s41572-021-00289-8-
dc.identifier.pmid34354083-
dc.identifier.scopuseid_2-s2.0-85112614581-
dc.identifier.hkuros329767-
dc.identifier.volume7-
dc.identifier.issue1-
dc.identifier.spagearticle no. 57-
dc.identifier.epagearticle no. 57-
dc.identifier.isiWOS:000683894800002-
dc.publisher.placeUnited Kingdom-

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