Links for fulltext
(May Require Subscription)
- Publisher Website: 10.3390/bios11110412
- Scopus: eid_2-s2.0-85118492085
- PMID: 34821628
- WOS: WOS:000728003200001
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: A Review of Advanced Impedance Biosensors with Microfluidic Chips for Single-Cell Analysis
Title | A Review of Advanced Impedance Biosensors with Microfluidic Chips for Single-Cell Analysis |
---|---|
Authors | |
Keywords | Impedance sensor Microfluidic chip Biosensor Single cell trapping |
Issue Date | 2021 |
Publisher | MDPI AG. The Journal's web site is located at https://www.mdpi.com/journal/biosensors |
Citation | Biosensors, 2021, v. 11 n. 11, article no. 412 How to Cite? |
Abstract | Electrical impedance biosensors combined with microfluidic devices can be used to analyze fundamental biological processes for high-throughput analysis at the single-cell scale. These specialized analytical tools can determine the effectiveness and toxicity of drugs with high sensitivity and demonstrate biological functions on a single-cell scale. Because the various parameters of the cells can be measured depending on methods of single-cell trapping, technological development ultimately determine the efficiency and performance of the sensors. Identifying the latest trends in single-cell trapping technologies afford opportunities such as new structural design and combination with other technologies. This will lead to more advanced applications towards improving measurement sensitivity to the desired target. In this review, we examined the basic principles of impedance sensors and their applications in various biological fields. In the next step, we introduced the latest trend of microfluidic chip technology for trapping single cells and summarized the important findings on the characteristics of single cells in impedance biosensor systems that successfully trapped single cells. This is expected to be used as a leading technology in cell biology, pathology, and pharmacological fields, promoting the further understanding of complex functions and mechanisms within individual cells with numerous data sampling and accurate analysis capabilities. |
Persistent Identifier | http://hdl.handle.net/10722/307674 |
ISSN | 2023 Impact Factor: 4.9 2023 SCImago Journal Rankings: 0.707 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, S | - |
dc.contributor.author | Song, H | - |
dc.contributor.author | Ahn, H | - |
dc.contributor.author | Kim, T | - |
dc.contributor.author | Jung, J | - |
dc.contributor.author | Cho, SK | - |
dc.contributor.author | Shin, D | - |
dc.contributor.author | Choi, J | - |
dc.contributor.author | Hwang, Y | - |
dc.contributor.author | Kim, K | - |
dc.date.accessioned | 2021-11-12T13:36:09Z | - |
dc.date.available | 2021-11-12T13:36:09Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Biosensors, 2021, v. 11 n. 11, article no. 412 | - |
dc.identifier.issn | 2079-6374 | - |
dc.identifier.uri | http://hdl.handle.net/10722/307674 | - |
dc.description.abstract | Electrical impedance biosensors combined with microfluidic devices can be used to analyze fundamental biological processes for high-throughput analysis at the single-cell scale. These specialized analytical tools can determine the effectiveness and toxicity of drugs with high sensitivity and demonstrate biological functions on a single-cell scale. Because the various parameters of the cells can be measured depending on methods of single-cell trapping, technological development ultimately determine the efficiency and performance of the sensors. Identifying the latest trends in single-cell trapping technologies afford opportunities such as new structural design and combination with other technologies. This will lead to more advanced applications towards improving measurement sensitivity to the desired target. In this review, we examined the basic principles of impedance sensors and their applications in various biological fields. In the next step, we introduced the latest trend of microfluidic chip technology for trapping single cells and summarized the important findings on the characteristics of single cells in impedance biosensor systems that successfully trapped single cells. This is expected to be used as a leading technology in cell biology, pathology, and pharmacological fields, promoting the further understanding of complex functions and mechanisms within individual cells with numerous data sampling and accurate analysis capabilities. | - |
dc.language | eng | - |
dc.publisher | MDPI AG. The Journal's web site is located at https://www.mdpi.com/journal/biosensors | - |
dc.relation.ispartof | Biosensors | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Impedance sensor | - |
dc.subject | Microfluidic chip | - |
dc.subject | Biosensor | - |
dc.subject | Single cell trapping | - |
dc.title | A Review of Advanced Impedance Biosensors with Microfluidic Chips for Single-Cell Analysis | - |
dc.type | Article | - |
dc.identifier.email | Shin, D: dmshin@hku.hk | - |
dc.identifier.authority | Shin, D=rp02569 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.3390/bios11110412 | - |
dc.identifier.pmid | 34821628 | - |
dc.identifier.pmcid | PMC8615569 | - |
dc.identifier.scopus | eid_2-s2.0-85118492085 | - |
dc.identifier.hkuros | 329777 | - |
dc.identifier.volume | 11 | - |
dc.identifier.issue | 11 | - |
dc.identifier.spage | article no. 412 | - |
dc.identifier.epage | article no. 412 | - |
dc.identifier.isi | WOS:000728003200001 | - |
dc.publisher.place | Switzerland | - |