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- Publisher Website: 10.1016/j.mce.2021.111460
- Scopus: eid_2-s2.0-85116440754
- PMID: 34543700
- WOS: WOS:000708861200008
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Article: Overexpression of Lin28a induces a primary ovarian insufficiency phenotype via facilitation of primordial follicle activation in mice
Title | Overexpression of Lin28a induces a primary ovarian insufficiency phenotype via facilitation of primordial follicle activation in mice |
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Authors | |
Keywords | Lin28a Wnt LRP5 mTOR Primordial follicle activation |
Issue Date | 2022 |
Publisher | Elsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/mce |
Citation | Molecular and Cellular Endocrinology, 2022, v. 539, article no. 111460 How to Cite? |
Abstract | Lin28a is an RNA binding protein and increasing evidence has indicated its role in regulating female fertility. Lin28a has been reported to be involved in ovarian follicle activation. However, its role and mechanisms in regulating primordial follicle activation have not yet been explored. To test whether overexpression of Lin28a activates ovarian primordial follicles, studies were conducted in wild type (WT) and Lin28a Tg mice. Female Lin28a Tg mice at 4-month old exhibited significantly smaller litter size and fewer ovulated oocytes when compared with the WT mice. By 6-month of age, these parameters in Lin28a Tg mice were less than 20% of the WT mice. At postnatal day (PD) 14, the number of primordial follicles was significantly decreased but the number of primary follicles was significantly increased in the transgenic mice. The number of primordial follicles, secondary and antral follicles in these mice were drastically reduced at PD21. In the ovary of Lin28a Tg mice, there were activation of Wnt/β-catenin signaling and its downstream mTOR pathway. Interestingly, overexpression of Lin28a, which can also act as transcriptional activator, activated Wnt signaling through enhancing the transcription of Wnt co-receptor LRP5. In conclusion, overexpression of Lin28a induced a primary ovarian insufficiency phenotype in long term via facilitating Wnt/β-catenin signaling leading to activation of primordial follicles. |
Persistent Identifier | http://hdl.handle.net/10722/307752 |
ISSN | 2023 Impact Factor: 3.8 2023 SCImago Journal Rankings: 1.130 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Chen, J | - |
dc.contributor.author | Liu, W | - |
dc.contributor.author | Lee, KF | - |
dc.contributor.author | Liu, K | - |
dc.contributor.author | Wong, BPC | - |
dc.contributor.author | Yeung, WSB | - |
dc.date.accessioned | 2021-11-12T13:37:18Z | - |
dc.date.available | 2021-11-12T13:37:18Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | Molecular and Cellular Endocrinology, 2022, v. 539, article no. 111460 | - |
dc.identifier.issn | 0303-7207 | - |
dc.identifier.uri | http://hdl.handle.net/10722/307752 | - |
dc.description.abstract | Lin28a is an RNA binding protein and increasing evidence has indicated its role in regulating female fertility. Lin28a has been reported to be involved in ovarian follicle activation. However, its role and mechanisms in regulating primordial follicle activation have not yet been explored. To test whether overexpression of Lin28a activates ovarian primordial follicles, studies were conducted in wild type (WT) and Lin28a Tg mice. Female Lin28a Tg mice at 4-month old exhibited significantly smaller litter size and fewer ovulated oocytes when compared with the WT mice. By 6-month of age, these parameters in Lin28a Tg mice were less than 20% of the WT mice. At postnatal day (PD) 14, the number of primordial follicles was significantly decreased but the number of primary follicles was significantly increased in the transgenic mice. The number of primordial follicles, secondary and antral follicles in these mice were drastically reduced at PD21. In the ovary of Lin28a Tg mice, there were activation of Wnt/β-catenin signaling and its downstream mTOR pathway. Interestingly, overexpression of Lin28a, which can also act as transcriptional activator, activated Wnt signaling through enhancing the transcription of Wnt co-receptor LRP5. In conclusion, overexpression of Lin28a induced a primary ovarian insufficiency phenotype in long term via facilitating Wnt/β-catenin signaling leading to activation of primordial follicles. | - |
dc.language | eng | - |
dc.publisher | Elsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/mce | - |
dc.relation.ispartof | Molecular and Cellular Endocrinology | - |
dc.subject | Lin28a | - |
dc.subject | Wnt | - |
dc.subject | LRP5 | - |
dc.subject | mTOR | - |
dc.subject | Primordial follicle activation | - |
dc.title | Overexpression of Lin28a induces a primary ovarian insufficiency phenotype via facilitation of primordial follicle activation in mice | - |
dc.type | Article | - |
dc.identifier.email | Liu, W: liuwm@hkucc.hku.hk | - |
dc.identifier.email | Lee, KF: ckflee@hku.hk | - |
dc.identifier.email | Liu, K: kliugc@hku.hk | - |
dc.identifier.email | Yeung, WSB: wsbyeung@hku.hk | - |
dc.identifier.authority | Lee, KF=rp00458 | - |
dc.identifier.authority | Liu, K=rp02475 | - |
dc.identifier.authority | Yeung, WSB=rp00331 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.mce.2021.111460 | - |
dc.identifier.pmid | 34543700 | - |
dc.identifier.scopus | eid_2-s2.0-85116440754 | - |
dc.identifier.hkuros | 329649 | - |
dc.identifier.volume | 539 | - |
dc.identifier.spage | article no. 111460 | - |
dc.identifier.epage | article no. 111460 | - |
dc.identifier.isi | WOS:000708861200008 | - |
dc.publisher.place | Ireland | - |