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Article: Neuroprotective Effects and Therapeutic Potential of Transcorneal Electrical Stimulation for Depression

TitleNeuroprotective Effects and Therapeutic Potential of Transcorneal Electrical Stimulation for Depression
Authors
KeywordsTES
Transcorneal electrical stimulation
Neuromodulation
Depression
Antidepressant
Neuroprotection
Issue Date2021
PublisherMDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/cells
Citation
Cells, 2021, v. 10 n. 9, article no. 2492 How to Cite?
AbstractTranscorneal electrical stimulation (TES) has emerged as a non-invasive neuromodulation approach that exerts neuroprotection via diverse mechanisms, including neurotrophic, neuroplastic, anti-inflammatory, anti-apoptotic, anti-glutamatergic, and vasodilation mechanisms. Although current studies of TES have mainly focused on its applications in ophthalmology, several lines of evidence point towards its putative use in treating depression. Apart from stimulating visual-related structures and promoting visual restoration, TES has also been shown to activate brain regions that are involved in mood alterations and can induce antidepressant-like behaviour in animals. The beneficial effects of TES in depression were further supported by its shared mechanisms with FDA-approved antidepressant treatments, including its neuroprotective properties against apoptosis and inflammation, and its ability to enhance the neurotrophic expression. This article critically reviews the current findings on the neuroprotective effects of TES and provides evidence to support our hypothesis that TES possesses antidepressant effects.
Persistent Identifierhttp://hdl.handle.net/10722/307823
ISSN
2023 Impact Factor: 5.1
2023 SCImago Journal Rankings: 1.547
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYu, WS-
dc.contributor.authorKwon, SH-
dc.contributor.authorAgadagba, SK-
dc.contributor.authorChan, LLH-
dc.contributor.authorWong, KH-
dc.contributor.authorLim, LW-
dc.date.accessioned2021-11-12T13:38:25Z-
dc.date.available2021-11-12T13:38:25Z-
dc.date.issued2021-
dc.identifier.citationCells, 2021, v. 10 n. 9, article no. 2492-
dc.identifier.issn2073-4409-
dc.identifier.urihttp://hdl.handle.net/10722/307823-
dc.description.abstractTranscorneal electrical stimulation (TES) has emerged as a non-invasive neuromodulation approach that exerts neuroprotection via diverse mechanisms, including neurotrophic, neuroplastic, anti-inflammatory, anti-apoptotic, anti-glutamatergic, and vasodilation mechanisms. Although current studies of TES have mainly focused on its applications in ophthalmology, several lines of evidence point towards its putative use in treating depression. Apart from stimulating visual-related structures and promoting visual restoration, TES has also been shown to activate brain regions that are involved in mood alterations and can induce antidepressant-like behaviour in animals. The beneficial effects of TES in depression were further supported by its shared mechanisms with FDA-approved antidepressant treatments, including its neuroprotective properties against apoptosis and inflammation, and its ability to enhance the neurotrophic expression. This article critically reviews the current findings on the neuroprotective effects of TES and provides evidence to support our hypothesis that TES possesses antidepressant effects.-
dc.languageeng-
dc.publisherMDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/cells-
dc.relation.ispartofCells-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectTES-
dc.subjectTranscorneal electrical stimulation-
dc.subjectNeuromodulation-
dc.subjectDepression-
dc.subjectAntidepressant-
dc.subjectNeuroprotection-
dc.titleNeuroprotective Effects and Therapeutic Potential of Transcorneal Electrical Stimulation for Depression-
dc.typeArticle-
dc.identifier.emailLim, LW: limlw@hku.hk-
dc.identifier.authorityLim, LW=rp02088-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3390/cells10092492-
dc.identifier.pmid34572141-
dc.identifier.pmcidPMC8466154-
dc.identifier.scopuseid_2-s2.0-85115888873-
dc.identifier.hkuros330351-
dc.identifier.volume10-
dc.identifier.issue9-
dc.identifier.spagearticle no. 2492-
dc.identifier.epagearticle no. 2492-
dc.identifier.isiWOS:000699150900001-
dc.publisher.placeSwitzerland-

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