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Article: Therapeutic potential and mechanism of Dendrobium officinale polysaccharides on cigarette smoke-induced airway inflammation in rat

TitleTherapeutic potential and mechanism of Dendrobium officinale polysaccharides on cigarette smoke-induced airway inflammation in rat
Authors
KeywordsAirway inflammation
Cigarette smoke
COPD
Dendrobium Officinale
Polysaccharides
Issue Date2021
PublisherElsevier: Creative Commons Licenses. The Journal's web site is located at http://www.elsevier.com/locate/biopha
Citation
Biomedicine & Pharmacotherapy, 2021, v. 143, p. article no. 112101 How to Cite?
AbstractChronic obstructive pulmonary disease (COPD) is among the leading causes of death worldwide, and is characterized by persistent respiratory symptoms and airflow limitation due to chronic airway inflammation. Cigarette smoking is a major risk factor for COPD. This study aims to determine the therapeutic effects of polysaccharides extracted from Dendrobium officinale (DOPs), a valuable traditional Chinese Medicinal herb, on cigarette smoke (CS)-induced airway inflammation in a rat passive smoking model. Male Sprague-Dawley rats were exposed to CS or sham air (SA) as control for a 56-day period. On Day 29, rats were subdivided and given water, DOPs or N-acetylcysteine (NAC) via oral gavage on a daily basis for the remaining duration. DOPs reduced CS-induced oxidative stress as evidenced by reducing malondialdehyde (MDA) levels in the lung. DOPs also exerted potent anti-inflammatory properties as evidenced by a reduction in the number of lymphocytes and monocytes in serum, significantly attenuating infiltration of inflammatory cells in lung tissue, as well as pro-inflammatory mediators in serum, bronchoalveolar lavage (BAL) and lung. Additionally, DOPs inhibited the CS-induced activation of ERK, p38 MAPK and NF-κB signaling pathways. These findings suggest that DOPs may have potentially beneficial effects in limiting smoking-related lung oxidative stress, and inflammation mediated via the inhibition of MAPK and NF-κB signaling pathways in smokers, without or with COPD.
Persistent Identifierhttp://hdl.handle.net/10722/307887
ISSN
2021 Impact Factor: 7.419
2020 SCImago Journal Rankings: 1.323
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLiang, Y-
dc.contributor.authorDu, R-
dc.contributor.authorChen, R-
dc.contributor.authorChu, PH-
dc.contributor.authorIp, MSM-
dc.contributor.authorZhang, KYB-
dc.contributor.authorMak, JCW-
dc.date.accessioned2021-11-12T13:39:21Z-
dc.date.available2021-11-12T13:39:21Z-
dc.date.issued2021-
dc.identifier.citationBiomedicine & Pharmacotherapy, 2021, v. 143, p. article no. 112101-
dc.identifier.issn0753-3322-
dc.identifier.urihttp://hdl.handle.net/10722/307887-
dc.description.abstractChronic obstructive pulmonary disease (COPD) is among the leading causes of death worldwide, and is characterized by persistent respiratory symptoms and airflow limitation due to chronic airway inflammation. Cigarette smoking is a major risk factor for COPD. This study aims to determine the therapeutic effects of polysaccharides extracted from Dendrobium officinale (DOPs), a valuable traditional Chinese Medicinal herb, on cigarette smoke (CS)-induced airway inflammation in a rat passive smoking model. Male Sprague-Dawley rats were exposed to CS or sham air (SA) as control for a 56-day period. On Day 29, rats were subdivided and given water, DOPs or N-acetylcysteine (NAC) via oral gavage on a daily basis for the remaining duration. DOPs reduced CS-induced oxidative stress as evidenced by reducing malondialdehyde (MDA) levels in the lung. DOPs also exerted potent anti-inflammatory properties as evidenced by a reduction in the number of lymphocytes and monocytes in serum, significantly attenuating infiltration of inflammatory cells in lung tissue, as well as pro-inflammatory mediators in serum, bronchoalveolar lavage (BAL) and lung. Additionally, DOPs inhibited the CS-induced activation of ERK, p38 MAPK and NF-κB signaling pathways. These findings suggest that DOPs may have potentially beneficial effects in limiting smoking-related lung oxidative stress, and inflammation mediated via the inhibition of MAPK and NF-κB signaling pathways in smokers, without or with COPD.-
dc.languageeng-
dc.publisherElsevier: Creative Commons Licenses. The Journal's web site is located at http://www.elsevier.com/locate/biopha-
dc.relation.ispartofBiomedicine & Pharmacotherapy-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectAirway inflammation-
dc.subjectCigarette smoke-
dc.subjectCOPD-
dc.subjectDendrobium Officinale-
dc.subjectPolysaccharides-
dc.titleTherapeutic potential and mechanism of Dendrobium officinale polysaccharides on cigarette smoke-induced airway inflammation in rat-
dc.typeArticle-
dc.identifier.emailLiang, Y: winniell@hku.hk-
dc.identifier.emailChen, R: rchen20@hku.hk-
dc.identifier.emailChu, PH: phchu731@HKUCC-COM.hku.hk-
dc.identifier.emailIp, MSM: msmip@hku.hk-
dc.identifier.emailMak, JCW: judithmak@hku.hk-
dc.identifier.authorityIp, MSM=rp00347-
dc.identifier.authorityZhang, KYB=rp01410-
dc.identifier.authorityMak, JCW=rp00352-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1016/j.biopha.2021.112101-
dc.identifier.pmid34474340-
dc.identifier.scopuseid_2-s2.0-85114013685-
dc.identifier.hkuros329661-
dc.identifier.volume143-
dc.identifier.spagearticle no. 112101-
dc.identifier.epagearticle no. 112101-
dc.identifier.isiWOS:000708088500007-
dc.publisher.placeFrance-

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