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Article: Spinal Cord Stimulation and Treatment of Peripheral or Central Neuropathic Pain: Mechanisms and Clinical Application

TitleSpinal Cord Stimulation and Treatment of Peripheral or Central Neuropathic Pain: Mechanisms and Clinical Application
Authors
Editors
Editor(s):Sansevero, G
Issue Date2021
PublisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/np/
Citation
Neural Plasticity, 2021, v. 2021, p. article no. 5607898 How to Cite?
AbstractSpinal cord stimulation (SCS) as an evidence-based interventional treatment has been used and approved for clinical use in a variety of pathological states including peripheral neuropathic pain; however, until now, it has not been used for the treatment of spinal cord injury- (SCI-) induced central neuropathic pain. This paper reviews the underlying mechanisms of SCS-induced analgesia and its clinical application in the management of peripheral and central neuropathic pain. Evidence from recent research publications indicates that nociceptive processing at peripheral and central sensory systems is thought to be modulated by SCS through (i) inhibition of the ascending nociceptive transmission by the release of analgesic neurotransmitters such as GABA and endocannabinoids at the spinal dorsal horn; (ii) facilitation of the descending inhibition by release of noradrenalin, dopamine, and serotonin acting on their receptors in the spinal cord; and (iii) activation of a variety of supraspinal brain areas related to pain perception and emotion. These insights into the mechanisms have resulted in the clinically approved use of SCS in peripheral neuropathic pain states like Complex Regional Pain Syndrome (CRPS) and Failed Back Surgery Syndrome (FBSS). However, the mechanisms underlying SCS-induced pain relief in central neuropathic pain are only partly understood, and more research is needed before this therapy can be implemented in SCI patients with central neuropathic pain.
Persistent Identifierhttp://hdl.handle.net/10722/308062
ISSN
2021 Impact Factor: 3.144
2020 SCImago Journal Rankings: 1.288
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorSun, L-
dc.contributor.authorPeng, C-
dc.contributor.authorJoosten, E-
dc.contributor.authorCheung, CW-
dc.contributor.authorTan, F-
dc.contributor.authorJiang, W-
dc.contributor.authorShen, X-
dc.contributor.editorSansevero, G-
dc.date.accessioned2021-11-12T13:41:58Z-
dc.date.available2021-11-12T13:41:58Z-
dc.date.issued2021-
dc.identifier.citationNeural Plasticity, 2021, v. 2021, p. article no. 5607898-
dc.identifier.issn2090-5904-
dc.identifier.urihttp://hdl.handle.net/10722/308062-
dc.description.abstractSpinal cord stimulation (SCS) as an evidence-based interventional treatment has been used and approved for clinical use in a variety of pathological states including peripheral neuropathic pain; however, until now, it has not been used for the treatment of spinal cord injury- (SCI-) induced central neuropathic pain. This paper reviews the underlying mechanisms of SCS-induced analgesia and its clinical application in the management of peripheral and central neuropathic pain. Evidence from recent research publications indicates that nociceptive processing at peripheral and central sensory systems is thought to be modulated by SCS through (i) inhibition of the ascending nociceptive transmission by the release of analgesic neurotransmitters such as GABA and endocannabinoids at the spinal dorsal horn; (ii) facilitation of the descending inhibition by release of noradrenalin, dopamine, and serotonin acting on their receptors in the spinal cord; and (iii) activation of a variety of supraspinal brain areas related to pain perception and emotion. These insights into the mechanisms have resulted in the clinically approved use of SCS in peripheral neuropathic pain states like Complex Regional Pain Syndrome (CRPS) and Failed Back Surgery Syndrome (FBSS). However, the mechanisms underlying SCS-induced pain relief in central neuropathic pain are only partly understood, and more research is needed before this therapy can be implemented in SCI patients with central neuropathic pain.-
dc.languageeng-
dc.publisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/np/-
dc.relation.ispartofNeural Plasticity-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleSpinal Cord Stimulation and Treatment of Peripheral or Central Neuropathic Pain: Mechanisms and Clinical Application-
dc.typeArticle-
dc.identifier.emailCheung, CW: cheucw@hku.hk-
dc.identifier.authorityCheung, CW=rp00244-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1155/2021/5607898-
dc.identifier.pmid34721569-
dc.identifier.pmcidPMC8553441-
dc.identifier.scopuseid_2-s2.0-85118642904-
dc.identifier.hkuros329920-
dc.identifier.volume2021-
dc.identifier.spagearticle no. 5607898-
dc.identifier.epagearticle no. 5607898-
dc.publisher.placeUnited States-

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