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- Publisher Website: 10.1515/revneuro-2020-0075
- Scopus: eid_2-s2.0-85098884024
- PMID: 33661584
- WOS: WOS:000637284000002
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Article: Prospects of cell replacement therapy for the treatment of degenerative cervical myelopathy
Title | Prospects of cell replacement therapy for the treatment of degenerative cervical myelopathy |
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Authors | |
Keywords | cell therapy cervical myelopathy gliosis inflammation ischemia |
Issue Date | 2021 |
Publisher | Walter de Gruyter GmbH. The Journal's web site is located at http://www.degruyter.com/view/j/revneuro |
Citation | Reviews in the Neurosciences, 2021, v. 32 n. 3, p. 275-287 How to Cite? |
Abstract | Degenerative cervical myelopathy (DCM) presents insidiously during middle-age with deterioration in neurological function. It accounts for the most common cause of non-traumatic spinal cord injury in developed countries and disease prevalence is expected to rise with the aging population. Whilst surgery can prevent further deterioration, biological therapies may be required to restore neurological function in advanced disease. Cell replacement therapy has been inordinately focused on treatment of traumatic spinal cord injury yet holds immense promise in DCM. We build upon this thesis by reviewing the pathophysiology of DCM as revealed by cadaveric and molecular studies. Loss of oligodendrocytes and neurons occurs via apoptosis. The tissue microenvironment in DCM prior to end-stage disease is distinct from that following acute trauma, and in many ways more favourable to receiving exogenous cells. We highlight clinical considerations for cell replacement in DCM such as selection of cell type, timing and method of delivery, as well as biological treatment adjuncts. Critically, disease models often fail to mimic features of human pathology. We discuss directions for translational research towards clinical application. |
Persistent Identifier | http://hdl.handle.net/10722/308271 |
ISSN | 2023 Impact Factor: 3.4 2023 SCImago Journal Rankings: 1.108 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Shea, GKH | - |
dc.contributor.author | Koljonen, PA | - |
dc.contributor.author | Chan, YS | - |
dc.contributor.author | Cheung, KMC | - |
dc.date.accessioned | 2021-11-12T13:44:54Z | - |
dc.date.available | 2021-11-12T13:44:54Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Reviews in the Neurosciences, 2021, v. 32 n. 3, p. 275-287 | - |
dc.identifier.issn | 0334-1763 | - |
dc.identifier.uri | http://hdl.handle.net/10722/308271 | - |
dc.description.abstract | Degenerative cervical myelopathy (DCM) presents insidiously during middle-age with deterioration in neurological function. It accounts for the most common cause of non-traumatic spinal cord injury in developed countries and disease prevalence is expected to rise with the aging population. Whilst surgery can prevent further deterioration, biological therapies may be required to restore neurological function in advanced disease. Cell replacement therapy has been inordinately focused on treatment of traumatic spinal cord injury yet holds immense promise in DCM. We build upon this thesis by reviewing the pathophysiology of DCM as revealed by cadaveric and molecular studies. Loss of oligodendrocytes and neurons occurs via apoptosis. The tissue microenvironment in DCM prior to end-stage disease is distinct from that following acute trauma, and in many ways more favourable to receiving exogenous cells. We highlight clinical considerations for cell replacement in DCM such as selection of cell type, timing and method of delivery, as well as biological treatment adjuncts. Critically, disease models often fail to mimic features of human pathology. We discuss directions for translational research towards clinical application. | - |
dc.language | eng | - |
dc.publisher | Walter de Gruyter GmbH. The Journal's web site is located at http://www.degruyter.com/view/j/revneuro | - |
dc.relation.ispartof | Reviews in the Neurosciences | - |
dc.subject | cell therapy | - |
dc.subject | cervical myelopathy | - |
dc.subject | gliosis | - |
dc.subject | inflammation | - |
dc.subject | ischemia | - |
dc.title | Prospects of cell replacement therapy for the treatment of degenerative cervical myelopathy | - |
dc.type | Article | - |
dc.identifier.email | Shea, GKH: gkshea@hku.hk | - |
dc.identifier.email | Koljonen, PA: kpa229@hku.hk | - |
dc.identifier.email | Chan, YS: yschan@hku.hk | - |
dc.identifier.email | Cheung, KMC: cheungmc@hku.hk | - |
dc.identifier.authority | Shea, GKH=rp01781 | - |
dc.identifier.authority | Chan, YS=rp00318 | - |
dc.identifier.authority | Cheung, KMC=rp00387 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1515/revneuro-2020-0075 | - |
dc.identifier.pmid | 33661584 | - |
dc.identifier.scopus | eid_2-s2.0-85098884024 | - |
dc.identifier.hkuros | 329775 | - |
dc.identifier.hkuros | 325857 | - |
dc.identifier.volume | 32 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 275 | - |
dc.identifier.epage | 287 | - |
dc.identifier.isi | WOS:000637284000002 | - |
dc.publisher.place | Germany | - |