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Article: Prospects of cell replacement therapy for the treatment of degenerative cervical myelopathy

TitleProspects of cell replacement therapy for the treatment of degenerative cervical myelopathy
Authors
Keywordscell therapy
cervical myelopathy
gliosis
inflammation
ischemia
Issue Date2021
PublisherWalter de Gruyter GmbH. The Journal's web site is located at http://www.degruyter.com/view/j/revneuro
Citation
Reviews in the Neurosciences, 2021, v. 32 n. 3, p. 275-287 How to Cite?
AbstractDegenerative cervical myelopathy (DCM) presents insidiously during middle-age with deterioration in neurological function. It accounts for the most common cause of non-traumatic spinal cord injury in developed countries and disease prevalence is expected to rise with the aging population. Whilst surgery can prevent further deterioration, biological therapies may be required to restore neurological function in advanced disease. Cell replacement therapy has been inordinately focused on treatment of traumatic spinal cord injury yet holds immense promise in DCM. We build upon this thesis by reviewing the pathophysiology of DCM as revealed by cadaveric and molecular studies. Loss of oligodendrocytes and neurons occurs via apoptosis. The tissue microenvironment in DCM prior to end-stage disease is distinct from that following acute trauma, and in many ways more favourable to receiving exogenous cells. We highlight clinical considerations for cell replacement in DCM such as selection of cell type, timing and method of delivery, as well as biological treatment adjuncts. Critically, disease models often fail to mimic features of human pathology. We discuss directions for translational research towards clinical application.
Persistent Identifierhttp://hdl.handle.net/10722/308271
ISSN
2021 Impact Factor: 4.703
2020 SCImago Journal Rankings: 1.172
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorShea, GKH-
dc.contributor.authorKoljonen, PA-
dc.contributor.authorChan, YS-
dc.contributor.authorCheung, KMC-
dc.date.accessioned2021-11-12T13:44:54Z-
dc.date.available2021-11-12T13:44:54Z-
dc.date.issued2021-
dc.identifier.citationReviews in the Neurosciences, 2021, v. 32 n. 3, p. 275-287-
dc.identifier.issn0334-1763-
dc.identifier.urihttp://hdl.handle.net/10722/308271-
dc.description.abstractDegenerative cervical myelopathy (DCM) presents insidiously during middle-age with deterioration in neurological function. It accounts for the most common cause of non-traumatic spinal cord injury in developed countries and disease prevalence is expected to rise with the aging population. Whilst surgery can prevent further deterioration, biological therapies may be required to restore neurological function in advanced disease. Cell replacement therapy has been inordinately focused on treatment of traumatic spinal cord injury yet holds immense promise in DCM. We build upon this thesis by reviewing the pathophysiology of DCM as revealed by cadaveric and molecular studies. Loss of oligodendrocytes and neurons occurs via apoptosis. The tissue microenvironment in DCM prior to end-stage disease is distinct from that following acute trauma, and in many ways more favourable to receiving exogenous cells. We highlight clinical considerations for cell replacement in DCM such as selection of cell type, timing and method of delivery, as well as biological treatment adjuncts. Critically, disease models often fail to mimic features of human pathology. We discuss directions for translational research towards clinical application.-
dc.languageeng-
dc.publisherWalter de Gruyter GmbH. The Journal's web site is located at http://www.degruyter.com/view/j/revneuro-
dc.relation.ispartofReviews in the Neurosciences-
dc.subjectcell therapy-
dc.subjectcervical myelopathy-
dc.subjectgliosis-
dc.subjectinflammation-
dc.subjectischemia-
dc.titleProspects of cell replacement therapy for the treatment of degenerative cervical myelopathy-
dc.typeArticle-
dc.identifier.emailShea, GKH: gkshea@hku.hk-
dc.identifier.emailKoljonen, PA: kpa229@hku.hk-
dc.identifier.emailChan, YS: yschan@hku.hk-
dc.identifier.emailCheung, KMC: cheungmc@hku.hk-
dc.identifier.authorityShea, GKH=rp01781-
dc.identifier.authorityChan, YS=rp00318-
dc.identifier.authorityCheung, KMC=rp00387-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1515/revneuro-2020-0075-
dc.identifier.pmid33661584-
dc.identifier.scopuseid_2-s2.0-85098884024-
dc.identifier.hkuros329775-
dc.identifier.hkuros325857-
dc.identifier.volume32-
dc.identifier.issue3-
dc.identifier.spage275-
dc.identifier.epage287-
dc.identifier.isiWOS:000637284000002-
dc.publisher.placeGermany-

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