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- Publisher Website: 10.1186/s13287-019-1274-1
- Scopus: eid_2-s2.0-85068939620
- PMID: 31286997
- WOS: WOS:000475605000002
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Article: Strategies for derivation of endothelial lineages from human stem cells
Title | Strategies for derivation of endothelial lineages from human stem cells |
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Authors | |
Keywords | Endothelial cells Tissue engineering Human stem cells 3D EB formation |
Issue Date | 2019 |
Publisher | BioMed Central Ltd. The Journal's web site is located at http://www.stemcellres.com |
Citation | Stem Cell Research & Therapy, 2019, v. 10, p. article no. 200 How to Cite? |
Abstract | Accumulating evidence demonstrates that pre-vascularization of tissue-engineered constructs can significantly enhance their survival and engraftment upon transplantation. Endothelial cells (ECs), the basic component of vasculatures, are indispensable to the entire process of pre-vascularization. However, the source of ECs still poses an issue. Recent studies confirmed that diverse approaches are available in the derivation of ECs for tissue engineering, such as direct isolation of autologous ECs, reprogramming of somatic cells, and induced differentiation of stem cells in typology. Herein, we discussed a variety of human stem cells (i.e., totipotent, pluripotent, multipotent, oligopotent, and unipotent stem cells), which can be induced to differentiate into ECs and reviewed the multifarious approaches for EC generation, such as 3D EB formation for embryonic stem cells (ESCs), stem cell-somatic cell co-culture, and directed endothelial differentiation with growth factors in conventional 2D culture. |
Persistent Identifier | http://hdl.handle.net/10722/308338 |
ISSN | 2023 Impact Factor: 7.1 2023 SCImago Journal Rankings: 1.798 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Xu, M | - |
dc.contributor.author | He, J | - |
dc.contributor.author | Zhang, C | - |
dc.contributor.author | Xu, J | - |
dc.contributor.author | Wang, Y | - |
dc.date.accessioned | 2021-11-26T00:55:13Z | - |
dc.date.available | 2021-11-26T00:55:13Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Stem Cell Research & Therapy, 2019, v. 10, p. article no. 200 | - |
dc.identifier.issn | 1757-6512 | - |
dc.identifier.uri | http://hdl.handle.net/10722/308338 | - |
dc.description.abstract | Accumulating evidence demonstrates that pre-vascularization of tissue-engineered constructs can significantly enhance their survival and engraftment upon transplantation. Endothelial cells (ECs), the basic component of vasculatures, are indispensable to the entire process of pre-vascularization. However, the source of ECs still poses an issue. Recent studies confirmed that diverse approaches are available in the derivation of ECs for tissue engineering, such as direct isolation of autologous ECs, reprogramming of somatic cells, and induced differentiation of stem cells in typology. Herein, we discussed a variety of human stem cells (i.e., totipotent, pluripotent, multipotent, oligopotent, and unipotent stem cells), which can be induced to differentiate into ECs and reviewed the multifarious approaches for EC generation, such as 3D EB formation for embryonic stem cells (ESCs), stem cell-somatic cell co-culture, and directed endothelial differentiation with growth factors in conventional 2D culture. | - |
dc.language | eng | - |
dc.publisher | BioMed Central Ltd. The Journal's web site is located at http://www.stemcellres.com | - |
dc.relation.ispartof | Stem Cell Research & Therapy | - |
dc.rights | Stem Cell Research & Therapy. Copyright © BioMed Central Ltd. | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Endothelial cells | - |
dc.subject | Tissue engineering | - |
dc.subject | Human stem cells | - |
dc.subject | 3D EB formation | - |
dc.title | Strategies for derivation of endothelial lineages from human stem cells | - |
dc.type | Article | - |
dc.identifier.email | Zhang, C: zhangcf@hku.hk | - |
dc.identifier.email | Xu, J: xujg1982@connect.hku.hk | - |
dc.identifier.authority | Zhang, C=rp01408 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1186/s13287-019-1274-1 | - |
dc.identifier.pmid | 31286997 | - |
dc.identifier.pmcid | PMC6615090 | - |
dc.identifier.scopus | eid_2-s2.0-85068939620 | - |
dc.identifier.hkuros | 321155 | - |
dc.identifier.volume | 10 | - |
dc.identifier.spage | article no. 200 | - |
dc.identifier.epage | article no. 200 | - |
dc.identifier.isi | WOS:000475605000002 | - |
dc.publisher.place | United Kingdom | - |