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- Publisher Website: 10.1371/journal.pgen.1009742
- Scopus: eid_2-s2.0-85114826257
- PMID: 34499642
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Article: Germline genome editing: Moratorium, hard law, or an informed adaptive consensus?
Title | Germline genome editing: Moratorium, hard law, or an informed adaptive consensus? |
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Authors | |
Issue Date | 2021 |
Publisher | Public Library of Science. The Journal's web site is located at http://www.plosgenetics.org/ |
Citation | PLoS Genetics, 2021, v. 17 n. 9, article no. e1009742 How to Cite? |
Abstract | With the development of practical means of human germline genome editing (HGGE) in recent years, there have been calls for stricter regulation and oversight over HGGE interventions with potential for heritable changes in the germline. An international moratorium has been advocated. We examine the practicality of such a proposal, as well as of a regulation through the “traditional” mechanisms of international and municipal laws. We argue that these mechanisms are unlikely to achieve their intended objectives and that the better approach is to engage the international community of stakeholders, researchers, scientists, clinicians, and other workers directly involved in the field in working toward the development of an “informed adaptive consensus”. We offer suggestions as to how this may be achieved and how existing indirect levers of regulation may be harnessed toward this end. |
Persistent Identifier | http://hdl.handle.net/10722/309017 |
ISSN | 2014 Impact Factor: 7.528 2023 SCImago Journal Rankings: 2.219 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Kaan, T | - |
dc.contributor.author | Xafis, V | - |
dc.contributor.author | Schaefer, GO | - |
dc.contributor.author | Zhu, Y | - |
dc.contributor.author | Labude, MK | - |
dc.contributor.author | Chadwick, R | - |
dc.date.accessioned | 2021-12-14T01:39:28Z | - |
dc.date.available | 2021-12-14T01:39:28Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | PLoS Genetics, 2021, v. 17 n. 9, article no. e1009742 | - |
dc.identifier.issn | 1553-7390 | - |
dc.identifier.uri | http://hdl.handle.net/10722/309017 | - |
dc.description.abstract | With the development of practical means of human germline genome editing (HGGE) in recent years, there have been calls for stricter regulation and oversight over HGGE interventions with potential for heritable changes in the germline. An international moratorium has been advocated. We examine the practicality of such a proposal, as well as of a regulation through the “traditional” mechanisms of international and municipal laws. We argue that these mechanisms are unlikely to achieve their intended objectives and that the better approach is to engage the international community of stakeholders, researchers, scientists, clinicians, and other workers directly involved in the field in working toward the development of an “informed adaptive consensus”. We offer suggestions as to how this may be achieved and how existing indirect levers of regulation may be harnessed toward this end. | - |
dc.language | eng | - |
dc.publisher | Public Library of Science. The Journal's web site is located at http://www.plosgenetics.org/ | - |
dc.relation.ispartof | PLoS Genetics | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.title | Germline genome editing: Moratorium, hard law, or an informed adaptive consensus? | - |
dc.type | Article | - |
dc.identifier.email | Kaan, T: kaan@hku.hk | - |
dc.identifier.authority | Kaan, T=rp01913 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1371/journal.pgen.1009742 | - |
dc.identifier.pmid | 34499642 | - |
dc.identifier.pmcid | PMC8428541 | - |
dc.identifier.scopus | eid_2-s2.0-85114826257 | - |
dc.identifier.hkuros | 330737 | - |
dc.identifier.volume | 17 | - |
dc.identifier.issue | 9 | - |
dc.identifier.spage | article no. e1009742 | - |
dc.identifier.epage | article no. e1009742 | - |
dc.identifier.isi | WOS:000750858100005 | - |
dc.publisher.place | United States | - |