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Article: Shared Molecular Mechanisms between Atherosclerosis and Periodontitis by Analyzing the Transcriptomic Alterations of Peripheral Blood Monocytes

TitleShared Molecular Mechanisms between Atherosclerosis and Periodontitis by Analyzing the Transcriptomic Alterations of Peripheral Blood Monocytes
Authors
Issue Date2021
PublisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/cmmm/
Citation
Computational and Mathematical Methods in Medicine, 2021, v. 2021, p. article no. 1498431 How to Cite?
AbstractObjective. This study investigated the nature of shared transcriptomic alterations in PBMs from periodontitis and atherosclerosis to unravel molecular mechanisms underpinning their association. Methods. Gene expression data from PBMs from patients with periodontitis and those with atherosclerosis were each downloaded from the GEO database. Differentially expressed genes (DEGs) in periodontitis and atherosclerosis were identified through differential gene expression analysis. The disease-related known genes related to periodontitis and atherosclerosis each were downloaded from the DisGeNET database. A Venn diagram was constructed to identify crosstalk genes from four categories: DEGs expressed in periodontitis, periodontitis-related known genes, DEGs expressed in atherosclerosis, and atherosclerosis-related known genes. A weighted gene coexpression network analysis (WGCNA) was performed to identify significant coexpression modules, and then, coexpressed gene interaction networks belonging to each significant module were constructed to identify the core crosstalk genes. Results. Functional enrichment analysis of significant modules obtained by WGCNA analysis showed that several pathways might play the critical crosstalk role in linking both diseases, including bacterial invasion of epithelial cells, platelet activation, and Mitogen-Activated Protein Kinases (MAPK) signaling. By constructing the gene interaction network of significant modules, the core crosstalk genes in each module were identified and included: for GSE23746 dataset, RASGRP2 in the blue module and VAMP7 and SNX3 in the green module, as well as HMGB1 and SUMO1 in the turquoise module were identified; for GSE61490 dataset, SEC61G, PSMB2, SELPLG, and FIBP in the turquoise module were identified. Conclusion. Exploration of available transcriptomic datasets revealed core crosstalk genes (RASGRP2, VAMP7, SNX3, HMGB1, SUMO1, SEC61G, PSMB2, SELPLG, and FIBP) and significant pathways (bacterial invasion of epithelial cells, platelet activation, and MAPK signaling) as top candidate molecular linkage mechanisms between atherosclerosis and periodontitis.
Persistent Identifierhttp://hdl.handle.net/10722/309305
ISSN
2020 Impact Factor: 2.238
2020 SCImago Journal Rankings: 0.462
PubMed Central ID

 

DC FieldValueLanguage
dc.contributor.authorNing, W-
dc.contributor.authorMa, Y-
dc.contributor.authorLi, S-
dc.contributor.authorWang, X-
dc.contributor.authorPan, H-
dc.contributor.authorWei, C-
dc.contributor.authorZhang, S-
dc.contributor.authorBai, D-
dc.contributor.authorLiu, X-
dc.contributor.authorDeng, Y-
dc.contributor.authorAcharya, A-
dc.contributor.authorPelekos, G-
dc.contributor.authorSavkovic, V-
dc.contributor.authorLi, H-
dc.contributor.authorGaus, S-
dc.contributor.authorHaak, R-
dc.contributor.authorSchmalz, G-
dc.contributor.authorZiebolz, D-
dc.contributor.authorMa, Y-
dc.contributor.authorXu, Y-
dc.date.accessioned2021-12-29T02:13:11Z-
dc.date.available2021-12-29T02:13:11Z-
dc.date.issued2021-
dc.identifier.citationComputational and Mathematical Methods in Medicine, 2021, v. 2021, p. article no. 1498431-
dc.identifier.issn1748-670X-
dc.identifier.urihttp://hdl.handle.net/10722/309305-
dc.description.abstractObjective. This study investigated the nature of shared transcriptomic alterations in PBMs from periodontitis and atherosclerosis to unravel molecular mechanisms underpinning their association. Methods. Gene expression data from PBMs from patients with periodontitis and those with atherosclerosis were each downloaded from the GEO database. Differentially expressed genes (DEGs) in periodontitis and atherosclerosis were identified through differential gene expression analysis. The disease-related known genes related to periodontitis and atherosclerosis each were downloaded from the DisGeNET database. A Venn diagram was constructed to identify crosstalk genes from four categories: DEGs expressed in periodontitis, periodontitis-related known genes, DEGs expressed in atherosclerosis, and atherosclerosis-related known genes. A weighted gene coexpression network analysis (WGCNA) was performed to identify significant coexpression modules, and then, coexpressed gene interaction networks belonging to each significant module were constructed to identify the core crosstalk genes. Results. Functional enrichment analysis of significant modules obtained by WGCNA analysis showed that several pathways might play the critical crosstalk role in linking both diseases, including bacterial invasion of epithelial cells, platelet activation, and Mitogen-Activated Protein Kinases (MAPK) signaling. By constructing the gene interaction network of significant modules, the core crosstalk genes in each module were identified and included: for GSE23746 dataset, RASGRP2 in the blue module and VAMP7 and SNX3 in the green module, as well as HMGB1 and SUMO1 in the turquoise module were identified; for GSE61490 dataset, SEC61G, PSMB2, SELPLG, and FIBP in the turquoise module were identified. Conclusion. Exploration of available transcriptomic datasets revealed core crosstalk genes (RASGRP2, VAMP7, SNX3, HMGB1, SUMO1, SEC61G, PSMB2, SELPLG, and FIBP) and significant pathways (bacterial invasion of epithelial cells, platelet activation, and MAPK signaling) as top candidate molecular linkage mechanisms between atherosclerosis and periodontitis.-
dc.languageeng-
dc.publisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/cmmm/-
dc.relation.ispartofComputational and Mathematical Methods in Medicine-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleShared Molecular Mechanisms between Atherosclerosis and Periodontitis by Analyzing the Transcriptomic Alterations of Peripheral Blood Monocytes-
dc.typeArticle-
dc.identifier.emailPelekos, G: george74@hku.hk-
dc.identifier.authorityPelekos, G=rp01894-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1155/2021/1498431-
dc.identifier.pmid34899963-
dc.identifier.pmcidPMC8664523-
dc.identifier.scopuseid_2-s2.0-85121605297-
dc.identifier.hkuros331348-
dc.identifier.volume2021-
dc.identifier.spagearticle no. 1498431-
dc.identifier.epagearticle no. 1498431-
dc.publisher.placeUnited Kingdom-

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