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Article: Effect of Steroid in Local Infiltration Analgesia in One-Stage Bilateral Total Knee Arthroplasty: A Paired-Randomized Controlled Study

TitleEffect of Steroid in Local Infiltration Analgesia in One-Stage Bilateral Total Knee Arthroplasty: A Paired-Randomized Controlled Study
Authors
Keywordsfast-track arthroplasty
local infiltration analgesia
randomized controlled trial
steroid
total knee arthroplasty
Issue Date2020
Citation
Journal of Knee Surgery, 2020 How to Cite?
AbstractAlthough local infiltration analgesia (LIA) is effective in relieving pain after total knee arthroplasty (TKA), its effect is short lasting and the optimal combination of drugs is unknown. Steroids being a potent and long-acting anti-inflammatory drug might extend LIA's effect. This study aims to evaluate the role of steroids in LIA. This is a paired-randomized controlled study involving one-stage bilateral TKA patients. LIA containing ropivacaine, ketorolac, and adrenaline with or without triamcinolone was given. One knee was randomized to receive LIA with steroids, while the other received LIA without steroids. The primary outcome was knee pain in terms of the visual analog scale (VAS). Secondary outcomes were rehabilitation progress, functional scores, and complications. Outcomes were compared between the knees of the same patient and documented up to 1 year. A total of 45 patients (90 TKAs) were included. LIA with steroid knees showed lower VAS score at rest and during activity from postoperation day 1 to 5 and at 6 weeks (p < 0.05). Passive and active range of movement was also greater in LIA with steroid group from day 1 to 7 and day 2 to 5, respectively (p < 0.05). Steroid-treated knees also achieved active straight leg raise earlier (1.2 vs. 2.0 days, p < 0.05). No differences in Knee Society Score and complication rates between both groups. Steroids in LIA offer additional and extended benefit in pain control and rehabilitation after TKA, while no adverse effects were found up to 1-year follow-up.
Persistent Identifierhttp://hdl.handle.net/10722/309533
ISSN
2023 Impact Factor: 1.6
2023 SCImago Journal Rankings: 0.831
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChan, Vincent Wai Kwan-
dc.contributor.authorChan, Ping Keung-
dc.contributor.authorYan, Chun Hoi-
dc.contributor.authorFu, Chun Him Henry-
dc.contributor.authorChan, Chi Wing-
dc.contributor.authorChiu, Kwong Yuen-
dc.date.accessioned2021-12-29T07:02:39Z-
dc.date.available2021-12-29T07:02:39Z-
dc.date.issued2020-
dc.identifier.citationJournal of Knee Surgery, 2020-
dc.identifier.issn1538-8506-
dc.identifier.urihttp://hdl.handle.net/10722/309533-
dc.description.abstractAlthough local infiltration analgesia (LIA) is effective in relieving pain after total knee arthroplasty (TKA), its effect is short lasting and the optimal combination of drugs is unknown. Steroids being a potent and long-acting anti-inflammatory drug might extend LIA's effect. This study aims to evaluate the role of steroids in LIA. This is a paired-randomized controlled study involving one-stage bilateral TKA patients. LIA containing ropivacaine, ketorolac, and adrenaline with or without triamcinolone was given. One knee was randomized to receive LIA with steroids, while the other received LIA without steroids. The primary outcome was knee pain in terms of the visual analog scale (VAS). Secondary outcomes were rehabilitation progress, functional scores, and complications. Outcomes were compared between the knees of the same patient and documented up to 1 year. A total of 45 patients (90 TKAs) were included. LIA with steroid knees showed lower VAS score at rest and during activity from postoperation day 1 to 5 and at 6 weeks (p < 0.05). Passive and active range of movement was also greater in LIA with steroid group from day 1 to 7 and day 2 to 5, respectively (p < 0.05). Steroid-treated knees also achieved active straight leg raise earlier (1.2 vs. 2.0 days, p < 0.05). No differences in Knee Society Score and complication rates between both groups. Steroids in LIA offer additional and extended benefit in pain control and rehabilitation after TKA, while no adverse effects were found up to 1-year follow-up.-
dc.languageeng-
dc.relation.ispartofJournal of Knee Surgery-
dc.subjectfast-track arthroplasty-
dc.subjectlocal infiltration analgesia-
dc.subjectrandomized controlled trial-
dc.subjectsteroid-
dc.subjecttotal knee arthroplasty-
dc.titleEffect of Steroid in Local Infiltration Analgesia in One-Stage Bilateral Total Knee Arthroplasty: A Paired-Randomized Controlled Study-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1055/s-0040-1713811-
dc.identifier.pmid32688398-
dc.identifier.scopuseid_2-s2.0-85089096005-
dc.identifier.eissn1938-2480-
dc.identifier.isiWOS:000754051300014-

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