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- Publisher Website: 10.36721/PJPS.2022.35.1.SUP.195-201.1
- Scopus: eid_2-s2.0-85124600593
- PMID: 35228177
- WOS: WOS:000808296600005
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Article: Controlled release floating drug delivery system for proton pump inhibitors lansoprazole: In-vitro, In-vivo floating and pharmacokinetic evaluation
Title | Controlled release floating drug delivery system for proton pump inhibitors lansoprazole: In-vitro, In-vivo floating and pharmacokinetic evaluation |
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Authors | |
Keywords | Floating hydrogels gum tragacanth itaconic acid proton pump inhibitor prolonged drug delivery |
Issue Date | 2022 |
Publisher | University of Karachi, Faculty of Pharmacy. The Journal's web site is located at http://www.pjps.pk/ |
Citation | Pakistan Journal of Pharmaceutical Sciences, 2022, v. 35 n. 1, suppl., p. 195-201 How to Cite? |
Abstract | Lansoprazole (LPZ) show poor bioavailability because of first pass effect and absorption factors. The floating delivery systems could reduce fluctuations in plasma drug concentration through maintaining desirable plasma drug concentration. The objective of present study was to enhance bioavailability despite first pass effect through continuous availability of drug from floating system. Gum tragacanth (GT) and itaconic acid (IA) based floating hydrogels (FH) were synthesized. Parameters optimized were; microwave radiation exposure time, pH, GT:IA ratio and concentration of the glutaraldehyde. Optimized FH were evaluated for entrapment efficiency (% EE), in-vitro release, FTIR, SEM, and in-vitro and in-vivo floating study. Finally, pharmacokinetic was evaluated in ulcer-induced SD rats. Grafting percentage, swelling ratio and %EE of LPZ was 115%, ̴ 250% and 90%, respectively. Microwave radiation exposure time, pH of reaction medium, GT:IA ratios and cross linker concentration were 2 min, pH 5, ratios 2:1 and 0.02%, respectively. The optimized FH showed acceptable floating behavior. The X-ray images revealed that hydrogels remained floated over gastric contents up to 24 hours. The in-vitro release and pharmacokinetics revealed availability of LPZ upto to 24h in-vitro and in ulcer-induced SD rats, respectively. The present hydrogels based floating system of lansoprazole is capable to extend the gastric residence time upto 24 hours. |
Persistent Identifier | http://hdl.handle.net/10722/309883 |
ISSN | 2021 Impact Factor: 0.863 2020 SCImago Journal Rankings: 0.223 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Murad, S | - |
dc.contributor.author | Mudassir, J | - |
dc.contributor.author | Faiz, S | - |
dc.contributor.author | Zahra, A | - |
dc.contributor.author | Usman, F | - |
dc.contributor.author | Farhan, M | - |
dc.contributor.author | Arshad, MS | - |
dc.contributor.author | Abbas, N | - |
dc.contributor.author | Hussain, A | - |
dc.contributor.author | Baig, MMFA | - |
dc.date.accessioned | 2022-01-10T09:15:14Z | - |
dc.date.available | 2022-01-10T09:15:14Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | Pakistan Journal of Pharmaceutical Sciences, 2022, v. 35 n. 1, suppl., p. 195-201 | - |
dc.identifier.issn | 1011-601X | - |
dc.identifier.uri | http://hdl.handle.net/10722/309883 | - |
dc.description.abstract | Lansoprazole (LPZ) show poor bioavailability because of first pass effect and absorption factors. The floating delivery systems could reduce fluctuations in plasma drug concentration through maintaining desirable plasma drug concentration. The objective of present study was to enhance bioavailability despite first pass effect through continuous availability of drug from floating system. Gum tragacanth (GT) and itaconic acid (IA) based floating hydrogels (FH) were synthesized. Parameters optimized were; microwave radiation exposure time, pH, GT:IA ratio and concentration of the glutaraldehyde. Optimized FH were evaluated for entrapment efficiency (% EE), in-vitro release, FTIR, SEM, and in-vitro and in-vivo floating study. Finally, pharmacokinetic was evaluated in ulcer-induced SD rats. Grafting percentage, swelling ratio and %EE of LPZ was 115%, ̴ 250% and 90%, respectively. Microwave radiation exposure time, pH of reaction medium, GT:IA ratios and cross linker concentration were 2 min, pH 5, ratios 2:1 and 0.02%, respectively. The optimized FH showed acceptable floating behavior. The X-ray images revealed that hydrogels remained floated over gastric contents up to 24 hours. The in-vitro release and pharmacokinetics revealed availability of LPZ upto to 24h in-vitro and in ulcer-induced SD rats, respectively. The present hydrogels based floating system of lansoprazole is capable to extend the gastric residence time upto 24 hours. | - |
dc.language | eng | - |
dc.publisher | University of Karachi, Faculty of Pharmacy. The Journal's web site is located at http://www.pjps.pk/ | - |
dc.relation.ispartof | Pakistan Journal of Pharmaceutical Sciences | - |
dc.subject | Floating hydrogels | - |
dc.subject | gum tragacanth | - |
dc.subject | itaconic acid | - |
dc.subject | proton pump inhibitor | - |
dc.subject | prolonged drug delivery | - |
dc.title | Controlled release floating drug delivery system for proton pump inhibitors lansoprazole: In-vitro, In-vivo floating and pharmacokinetic evaluation | - |
dc.type | Article | - |
dc.identifier.email | Baig, MMFA: faran@hku.hk | - |
dc.identifier.authority | Baig, MMFA=rp02755 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.36721/PJPS.2022.35.1.SUP.195-201.1 | - |
dc.identifier.pmid | 35228177 | - |
dc.identifier.scopus | eid_2-s2.0-85124600593 | - |
dc.identifier.hkuros | 331406 | - |
dc.identifier.volume | 35 | - |
dc.identifier.issue | 1, suppl. | - |
dc.identifier.spage | 195 | - |
dc.identifier.epage | 201 | - |
dc.identifier.isi | WOS:000808296600005 | - |
dc.publisher.place | Pakistan | - |