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- Publisher Website: 10.1261/rna.079016.121
- PMID: 35031583
- WOS: WOS:000986948200001
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Article: Cytoplasmic RNA sensors and their interplay with RNA-binding partners in innate antiviral response: Theme and variations
Title | Cytoplasmic RNA sensors and their interplay with RNA-binding partners in innate antiviral response: Theme and variations |
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Authors | |
Keywords | RIG-I MDA5 PACT RIG-I-like receptors NOD-like receptors |
Issue Date | 2022 |
Publisher | Cold Spring Harbor Laboratory Press. The Journal's web site is located at https://rnajournal.cshlp.org/ |
Citation | RNA, 2022, v. 28 n. 4, p. 449-477 How to Cite? |
Abstract | Sensing of pathogen-associated molecular patterns including viral RNA by innate immunity represents the first line of defense against viral infection. In addition to RIG-I-like receptors and NOD-like receptors, several other RNA sensors are known to mediate innate antiviral response in the cytoplasm. Double-stranded RNA-binding protein PACT interacts with prototypic RNA sensor RIG-I to facilitate its recognition of viral RNA and induction of host interferon response, but variations of this theme are seen when the functions of RNA sensors are modulated by other RNA-binding proteins to impinge on antiviral defense, proinflammatory cytokine production and cell death programs. Their discrete and coordinated actions are crucial to protect the host from infection. In this review, we will focus on cytoplasmic RNA sensors with an emphasis on their interplay with RNA-binding partners. Classical sensors such as RIG-I will be briefly reviewed. More attention will be brought to new insights on how RNA-binding partners of RNA sensors modulate innate RNA sensing and how viruses perturb the functions of RNA-binding partners. |
Persistent Identifier | http://hdl.handle.net/10722/310092 |
ISSN | 2023 Impact Factor: 4.2 2023 SCImago Journal Rankings: 2.407 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Chan, CP | - |
dc.contributor.author | Jin, D | - |
dc.date.accessioned | 2022-01-24T02:23:42Z | - |
dc.date.available | 2022-01-24T02:23:42Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | RNA, 2022, v. 28 n. 4, p. 449-477 | - |
dc.identifier.issn | 1355-8382 | - |
dc.identifier.uri | http://hdl.handle.net/10722/310092 | - |
dc.description.abstract | Sensing of pathogen-associated molecular patterns including viral RNA by innate immunity represents the first line of defense against viral infection. In addition to RIG-I-like receptors and NOD-like receptors, several other RNA sensors are known to mediate innate antiviral response in the cytoplasm. Double-stranded RNA-binding protein PACT interacts with prototypic RNA sensor RIG-I to facilitate its recognition of viral RNA and induction of host interferon response, but variations of this theme are seen when the functions of RNA sensors are modulated by other RNA-binding proteins to impinge on antiviral defense, proinflammatory cytokine production and cell death programs. Their discrete and coordinated actions are crucial to protect the host from infection. In this review, we will focus on cytoplasmic RNA sensors with an emphasis on their interplay with RNA-binding partners. Classical sensors such as RIG-I will be briefly reviewed. More attention will be brought to new insights on how RNA-binding partners of RNA sensors modulate innate RNA sensing and how viruses perturb the functions of RNA-binding partners. | - |
dc.language | eng | - |
dc.publisher | Cold Spring Harbor Laboratory Press. The Journal's web site is located at https://rnajournal.cshlp.org/ | - |
dc.relation.ispartof | RNA | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | RIG-I | - |
dc.subject | MDA5 | - |
dc.subject | PACT | - |
dc.subject | RIG-I-like receptors | - |
dc.subject | NOD-like receptors | - |
dc.title | Cytoplasmic RNA sensors and their interplay with RNA-binding partners in innate antiviral response: Theme and variations | - |
dc.type | Article | - |
dc.identifier.email | Chan, CP: chancp10@hku.hk | - |
dc.identifier.email | Jin, D: dyjin@hku.hk | - |
dc.identifier.authority | Chan, CP=rp02031 | - |
dc.identifier.authority | Jin, D=rp00452 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1261/rna.079016.121 | - |
dc.identifier.pmid | 35031583 | - |
dc.identifier.pmcid | PMC8925969 | - |
dc.identifier.hkuros | 331560 | - |
dc.identifier.volume | 28 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 449 | - |
dc.identifier.epage | 477 | - |
dc.identifier.isi | WOS:000986948200001 | - |
dc.publisher.place | United States | - |