File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Estimating the transmission advantage of the D614G mutant strain of SARS-CoV-2, December 2019 to June 2020

TitleEstimating the transmission advantage of the D614G mutant strain of SARS-CoV-2, December 2019 to June 2020
Authors
KeywordsCOVID-19
D614G
SARS-CoV-2
fitness
mutation
Issue Date2021
PublisherEuropean Centre for Disease Prevention and Control. The Journal's web site is located at http://www.eurosurveillance.org/Public/AboutUs/AboutUs.aspx
Citation
Eurosurveillance, 2021, v. 26 n. 49, p. article no. 2002005 How to Cite?
AbstractIntroductionThe SARS-CoV-2 lineages carrying the amino acid change D614G have become the dominant variants in the global COVID-19 pandemic. By June 2021, all the emerging variants of concern carried the D614G mutation. The rapid spread of the G614 mutant suggests that it may have a transmission advantage over the D614 wildtype.AimOur objective was to estimate the transmission advantage of D614G by integrating phylogenetic and epidemiological analysis.MethodsWe assume that the mutation D614G was the only site of interest which characterised the two cocirculating virus strains by June 2020, but their differential transmissibility might be attributable to a combination of D614G and other mutations. We define the fitness of G614 as the ratio of the basic reproduction number of the strain with G614 to the strain with D614 and applied an epidemiological framework for fitness inference to analyse SARS-CoV-2 surveillance and sequence data.ResultsUsing this framework, we estimated that the G614 mutant is 31% (95% credible interval: 28-34) more transmissible than the D614 wildtype. Therefore, interventions that were previously effective in containing or mitigating the D614 wildtype (e.g. in China, Vietnam and Thailand) may be less effective against the G614 mutant.ConclusionOur framework can be readily integrated into current SARS-CoV-2 surveillance to monitor the emergence and fitness of mutant strains such that pandemic surveillance, disease control and development of treatment and vaccines can be adjusted dynamically.
Persistent Identifierhttp://hdl.handle.net/10722/310111
ISSN
2023 Impact Factor: 9.9
2023 SCImago Journal Rankings: 2.881
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLeung, K-
dc.contributor.authorPEI, Y-
dc.contributor.authorLeung, GM-
dc.contributor.authorLam, TY-
dc.contributor.authorWu, JTK-
dc.date.accessioned2022-01-24T02:23:58Z-
dc.date.available2022-01-24T02:23:58Z-
dc.date.issued2021-
dc.identifier.citationEurosurveillance, 2021, v. 26 n. 49, p. article no. 2002005-
dc.identifier.issn1025-496X-
dc.identifier.urihttp://hdl.handle.net/10722/310111-
dc.description.abstractIntroductionThe SARS-CoV-2 lineages carrying the amino acid change D614G have become the dominant variants in the global COVID-19 pandemic. By June 2021, all the emerging variants of concern carried the D614G mutation. The rapid spread of the G614 mutant suggests that it may have a transmission advantage over the D614 wildtype.AimOur objective was to estimate the transmission advantage of D614G by integrating phylogenetic and epidemiological analysis.MethodsWe assume that the mutation D614G was the only site of interest which characterised the two cocirculating virus strains by June 2020, but their differential transmissibility might be attributable to a combination of D614G and other mutations. We define the fitness of G614 as the ratio of the basic reproduction number of the strain with G614 to the strain with D614 and applied an epidemiological framework for fitness inference to analyse SARS-CoV-2 surveillance and sequence data.ResultsUsing this framework, we estimated that the G614 mutant is 31% (95% credible interval: 28-34) more transmissible than the D614 wildtype. Therefore, interventions that were previously effective in containing or mitigating the D614 wildtype (e.g. in China, Vietnam and Thailand) may be less effective against the G614 mutant.ConclusionOur framework can be readily integrated into current SARS-CoV-2 surveillance to monitor the emergence and fitness of mutant strains such that pandemic surveillance, disease control and development of treatment and vaccines can be adjusted dynamically.-
dc.languageeng-
dc.publisherEuropean Centre for Disease Prevention and Control. The Journal's web site is located at http://www.eurosurveillance.org/Public/AboutUs/AboutUs.aspx-
dc.relation.ispartofEurosurveillance-
dc.rightsEurosurveillance. Copyright © European Centre for Disease Prevention and Control.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectCOVID-19-
dc.subjectD614G-
dc.subjectSARS-CoV-2-
dc.subjectfitness-
dc.subjectmutation-
dc.titleEstimating the transmission advantage of the D614G mutant strain of SARS-CoV-2, December 2019 to June 2020-
dc.typeArticle-
dc.identifier.emailLeung, K: ksmleung@hku.hk-
dc.identifier.emailLeung, GM: gmleung@hku.hk-
dc.identifier.emailLam, TY: ttylam@hku.hk-
dc.identifier.emailWu, JTK: joewu@hku.hk-
dc.identifier.authorityLeung, K=rp02563-
dc.identifier.authorityLeung, GM=rp00460-
dc.identifier.authorityLam, TY=rp01733-
dc.identifier.authorityWu, JTK=rp00517-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.2807/1560-7917.ES.2021.26.49.2002005-
dc.identifier.pmid34886945-
dc.identifier.pmcidPMC8662801-
dc.identifier.scopuseid_2-s2.0-85122156912-
dc.identifier.hkuros331456-
dc.identifier.volume26-
dc.identifier.issue49-
dc.identifier.spagearticle no. 2002005-
dc.identifier.epagearticle no. 2002005-
dc.identifier.isiWOS:000744208800003-
dc.publisher.placeSweden-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats