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Article: Dengue seroprevalence and force of primary infection in a representative population of urban dwelling Indonesian children
Title | Dengue seroprevalence and force of primary infection in a representative population of urban dwelling Indonesian children |
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Authors | |
Issue Date | 2017 |
Citation | PLoS Neglected Tropical Diseases, 2017, v. 11, n. 6, article no. e0005621 How to Cite? |
Abstract | Background: Indonesia reports the second highest dengue disease burden in the world; these data are from passive surveillance reports and are likely to be significant underestimates. Age-stratified seroprevalence data are relatively unbiased indicators of past exposure and allow understanding of transmission dynamics. Methodology/Principal Findings: To better understand dengue infection history and associated risk factors in Indonesia, a representative population-based cross-sectional dengue seroprevalence study was conducted in 1–18-year-old urban children. From October to November 2014, 3,210 children were enrolled from 30 geographically dispersed clusters. Serum samples were tested for anti-dengue IgG antibodies by indirect ELISA. A questionnaire investigated associations between dengue serologic status and household socio-demographic and behavioural factors. Overall, 3,194 samples were tested, giving an adjusted national seroprevalence in this urban population of 69.4% [95% CI: 64.4–74.3] (33.8% [95% CI: 26.4–41.2] in the 1–4-year-olds, 65.4% [95% CI: 69.1–71.7] in the 5–9-year-olds, 83.1% [95% CI: 77.1–89.0] in the 10–14-year-olds, and 89.0% [95% CI: 83.9–94.1] in the 15–18-year–olds). The median age of seroconversion estimated through a linear model was 4.8 years. Using a catalytic model and considering a constant force of infection we estimated 13.1% of children experience a primary infection per year. Through a hierarchical logistic multivariate model, the subject’s age group (1–4 vs 5–9 OR = 4.25; 1–4 vs. 10–14 OR = 12.60; and 1–4 vs 15–18 OR = 21.87; p<0.0001) and the number of cases diagnosed in the household since the subject was born (p = 0.0004) remained associated with dengue serological status. Conclusions/Significance: This is the first dengue seroprevalence study in Indonesia that is targeting a representative sample of the urban paediatric population. This study revealed that more than 80% of children aged 10 years or over have experienced dengue infection at least once. Prospective incidence studies would likely reveal dengue burdens far in excess of reported incidence rates. |
Persistent Identifier | http://hdl.handle.net/10722/311432 |
ISSN | 2011 Impact Factor: 4.716 2023 SCImago Journal Rankings: 1.258 |
PubMed Central ID | |
ISI Accession Number ID | |
Errata |
DC Field | Value | Language |
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dc.contributor.author | Prayitno, Ari | - |
dc.contributor.author | Taurel, Anne Frieda | - |
dc.contributor.author | Nealon, Joshua | - |
dc.contributor.author | Satari, Hindra Irawan | - |
dc.contributor.author | Karyanti, Mulya Rahma | - |
dc.contributor.author | Sekartini, Rini | - |
dc.contributor.author | Soedjatmiko, Soedjatmiko | - |
dc.contributor.author | Gunardi, Hartono | - |
dc.contributor.author | Medise, Bernie Endyarni | - |
dc.contributor.author | Sasmono, R. Tedjo | - |
dc.contributor.author | Simmerman, James Mark | - |
dc.contributor.author | Bouckenooghe, Alain | - |
dc.contributor.author | Hadinegoro, Sri Rezeki | - |
dc.date.accessioned | 2022-03-22T11:53:55Z | - |
dc.date.available | 2022-03-22T11:53:55Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | PLoS Neglected Tropical Diseases, 2017, v. 11, n. 6, article no. e0005621 | - |
dc.identifier.issn | 1935-2727 | - |
dc.identifier.uri | http://hdl.handle.net/10722/311432 | - |
dc.description.abstract | Background: Indonesia reports the second highest dengue disease burden in the world; these data are from passive surveillance reports and are likely to be significant underestimates. Age-stratified seroprevalence data are relatively unbiased indicators of past exposure and allow understanding of transmission dynamics. Methodology/Principal Findings: To better understand dengue infection history and associated risk factors in Indonesia, a representative population-based cross-sectional dengue seroprevalence study was conducted in 1–18-year-old urban children. From October to November 2014, 3,210 children were enrolled from 30 geographically dispersed clusters. Serum samples were tested for anti-dengue IgG antibodies by indirect ELISA. A questionnaire investigated associations between dengue serologic status and household socio-demographic and behavioural factors. Overall, 3,194 samples were tested, giving an adjusted national seroprevalence in this urban population of 69.4% [95% CI: 64.4–74.3] (33.8% [95% CI: 26.4–41.2] in the 1–4-year-olds, 65.4% [95% CI: 69.1–71.7] in the 5–9-year-olds, 83.1% [95% CI: 77.1–89.0] in the 10–14-year-olds, and 89.0% [95% CI: 83.9–94.1] in the 15–18-year–olds). The median age of seroconversion estimated through a linear model was 4.8 years. Using a catalytic model and considering a constant force of infection we estimated 13.1% of children experience a primary infection per year. Through a hierarchical logistic multivariate model, the subject’s age group (1–4 vs 5–9 OR = 4.25; 1–4 vs. 10–14 OR = 12.60; and 1–4 vs 15–18 OR = 21.87; p<0.0001) and the number of cases diagnosed in the household since the subject was born (p = 0.0004) remained associated with dengue serological status. Conclusions/Significance: This is the first dengue seroprevalence study in Indonesia that is targeting a representative sample of the urban paediatric population. This study revealed that more than 80% of children aged 10 years or over have experienced dengue infection at least once. Prospective incidence studies would likely reveal dengue burdens far in excess of reported incidence rates. | - |
dc.language | eng | - |
dc.relation.ispartof | PLoS Neglected Tropical Diseases | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.title | Dengue seroprevalence and force of primary infection in a representative population of urban dwelling Indonesian children | - |
dc.type | Article | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1371/journal.pntd.0005621 | - |
dc.identifier.pmid | 28617803 | - |
dc.identifier.pmcid | PMC5472274 | - |
dc.identifier.scopus | eid_2-s2.0-85021663384 | - |
dc.identifier.volume | 11 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | article no. e0005621 | - |
dc.identifier.epage | article no. e0005621 | - |
dc.identifier.eissn | 1935-2735 | - |
dc.identifier.isi | WOS:000405080700023 | - |
dc.relation.erratum | doi:10.1371/journal.pntd.0006467 | - |
dc.relation.erratum | eid:eid_2-s2.0-85077191435 | - |