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- Publisher Website: 10.1038/srep26742
- Scopus: eid_2-s2.0-84971228935
- PMID: 27221530
- WOS: WOS:000376500800001
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Article: Combinations of oseltamivir and T-705 extend the treatment window for highly pathogenic influenza a (H5N1) virus infection in mice
Title | Combinations of oseltamivir and T-705 extend the treatment window for highly pathogenic influenza a (H5N1) virus infection in mice |
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Authors | |
Issue Date | 2016 |
Citation | Scientific Reports, 2016, v. 6, article no. 26742 How to Cite? |
Abstract | Current anti-influenza therapy depends on administering drugs soon after infection, which is often impractical. We assessed whether combinations of oseltamivir (a neuraminidase inhibitor) and T-705 (a nonspecific inhibitor of viral polymerases) could extend the window for treating lethal infection with highly pathogenic A(H5N1) influenza virus in mice. Combination therapy protected 100% of mice, even when delayed until 96 h postinoculation. Compared to animals receiving monotherapy, mice receiving combination therapy had reduced viral loads and restricted viral spread in lung tissues, limited lung damage, and decreased inflammatory cytokine production. Next-generation sequencing showed that virus populations in T-705-treated mice had greater genetic variability, with more frequent transversion events, than did populations in control and oseltamivir-treated mice, but no substitutions associated with resistance to oseltamivir or T-705 were detected. Thus, combination therapy extended the treatment window for A(H5N1) influenza infection in mice and should be considered for evaluation in a clinical setting. |
Persistent Identifier | http://hdl.handle.net/10722/312012 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Marathe, Bindumadhav M. | - |
dc.contributor.author | Wong, Sook San | - |
dc.contributor.author | Vogel, Peter | - |
dc.contributor.author | Garcia-Alcalde, Fernando | - |
dc.contributor.author | Webster, Robert G. | - |
dc.contributor.author | Webby, Richard J. | - |
dc.contributor.author | Najera, Isabel | - |
dc.contributor.author | Govorkova, Elena A. | - |
dc.date.accessioned | 2022-04-06T04:31:58Z | - |
dc.date.available | 2022-04-06T04:31:58Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Scientific Reports, 2016, v. 6, article no. 26742 | - |
dc.identifier.uri | http://hdl.handle.net/10722/312012 | - |
dc.description.abstract | Current anti-influenza therapy depends on administering drugs soon after infection, which is often impractical. We assessed whether combinations of oseltamivir (a neuraminidase inhibitor) and T-705 (a nonspecific inhibitor of viral polymerases) could extend the window for treating lethal infection with highly pathogenic A(H5N1) influenza virus in mice. Combination therapy protected 100% of mice, even when delayed until 96 h postinoculation. Compared to animals receiving monotherapy, mice receiving combination therapy had reduced viral loads and restricted viral spread in lung tissues, limited lung damage, and decreased inflammatory cytokine production. Next-generation sequencing showed that virus populations in T-705-treated mice had greater genetic variability, with more frequent transversion events, than did populations in control and oseltamivir-treated mice, but no substitutions associated with resistance to oseltamivir or T-705 were detected. Thus, combination therapy extended the treatment window for A(H5N1) influenza infection in mice and should be considered for evaluation in a clinical setting. | - |
dc.language | eng | - |
dc.relation.ispartof | Scientific Reports | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.title | Combinations of oseltamivir and T-705 extend the treatment window for highly pathogenic influenza a (H5N1) virus infection in mice | - |
dc.type | Article | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1038/srep26742 | - |
dc.identifier.pmid | 27221530 | - |
dc.identifier.pmcid | PMC4879667 | - |
dc.identifier.scopus | eid_2-s2.0-84971228935 | - |
dc.identifier.volume | 6 | - |
dc.identifier.spage | article no. 26742 | - |
dc.identifier.epage | article no. 26742 | - |
dc.identifier.eissn | 2045-2322 | - |
dc.identifier.isi | WOS:000376500800001 | - |