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Article: Severe Influenza Is Characterized by Prolonged Immune Activation: Results from the SHIVERS Cohort Study

TitleSevere Influenza Is Characterized by Prolonged Immune Activation: Results from the SHIVERS Cohort Study
Authors
Keywordscellular immunity
cytokine.
disease severity
infection
Influenza
Issue Date2018
Citation
Journal of Infectious Diseases, 2018, v. 217, n. 2, p. 245-256 How to Cite?
AbstractThe immunologic factors underlying severe influenza are poorly understood. To address this, we compared the immune responses of influenza-confirmed hospitalized individuals with severe acute respiratory illness (SARI) to those of nonhospitalized individuals with influenza-like illness (ILI). Methods. Peripheral blood lymphocytes were collected from 27 patients with ILI and 27 with SARI, at time of enrollment and then 2 weeks later. Innate and adaptive cellular immune responses were assessed by flow cytometry, and serum cytokine levels were assessed by a bead-based assay. Results. During the acute phase, SARI was associated with significantly reduced numbers of circulating myeloid dendritic cells, CD192+ monocytes, and influenza virus-specific CD8+ and CD4+ T cells as compared to ILI. By the convalescent phase, however, most SARI cases displayed continued immune activation characterized by increased numbers of CD16+ monocytes and proliferating, and influenza virus-specific, CD8+ T cells as compared to ILI cases. SARI was also associated with reduced amounts of cytokines that regulate T-cell responses (ie, interleukin 4, interleukin 13, interleukin 12, interleukin 10, and tumor necrosis factor â) and hematopoiesis (interleukin 3 and granulocyte-macrophage colony-stimulating factor) but increased amounts of a proinflammatory cytokine (tumor necrosis factor á), chemotactic cytokines (MDC, MCP-1, GRO, and fractalkine), and growth-promoting cytokines (PDGFBB/AA, VEGF, and EGF) as compared to ILI. Severe influenza cases showed a delay in the peripheral immune activation that likely led prolonged inflammation, compared with mild influenza cases.
Persistent Identifierhttp://hdl.handle.net/10722/312030
ISSN
2023 Impact Factor: 5.0
2023 SCImago Journal Rankings: 2.387
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWong, Sook San-
dc.contributor.authorOshansky, Christine M.-
dc.contributor.authorGuo, Xi Zhi J.-
dc.contributor.authorRalston, Jacqui-
dc.contributor.authorWood, Timothy-
dc.contributor.authorSeeds, Ruth-
dc.contributor.authorNewbern, Claire-
dc.contributor.authorWaite, Ben-
dc.contributor.authorReynolds, Gary-
dc.contributor.authorWiddowson, Marc Alain-
dc.contributor.authorHuang, Q. Sue-
dc.contributor.authorWebby, Richard J.-
dc.contributor.authorThomas, Paul G.-
dc.contributor.authorTurner, Nikki-
dc.contributor.authorBaker, Michael-
dc.contributor.authorGrant, Cameron-
dc.contributor.authorMcArthur, Colin-
dc.contributor.authorRoberts, Sally-
dc.contributor.authorTrenholmes, Adrian-
dc.contributor.authorWong, Conroy-
dc.contributor.authorTaylor, Susan-
dc.contributor.authorThompson, Mark-
dc.contributor.authorGross, Diane-
dc.contributor.authorDuque, Jazmin-
dc.contributor.authorHaven, Kathryn-
dc.contributor.authorAley, Debbie-
dc.contributor.authorMuponisi, Pamela-
dc.contributor.authorChand, Bhamita-
dc.contributor.authorChen, Yan-
dc.contributor.authorPlewes, Laurel-
dc.contributor.authorSawtell, Frann-
dc.contributor.authorLawrence, Shirley-
dc.contributor.authorCogcoy, Reniza-
dc.contributor.authorSmith, Jo-
dc.contributor.authorGravidez, Franie-
dc.contributor.authorMa, Mandy-
dc.contributor.authorChamberlin, Shona-
dc.contributor.authorDavey, Kirstin-
dc.contributor.authorKnowles, Tania-
dc.contributor.authorMcLeish, Jo Ann-
dc.contributor.authorTodd, A.-
dc.contributor.authorBocacao, J.-
dc.contributor.authorGunn, W.-
dc.contributor.authorKawakami, P.-
dc.contributor.authorWalker, S.-
dc.contributor.authorMadge, Robyn-
dc.contributor.authorMoore, N.-
dc.contributor.authorRahnama, Fahimeh-
dc.contributor.authorQiao, Helen-
dc.contributor.authorTse, Fifi-
dc.contributor.authorZibaei, Mahtab-
dc.contributor.authorKorrapadu, Tirzah-
dc.contributor.authorOptland, Louise-
dc.contributor.authorCruz, Cecilia Dela-
dc.date.accessioned2022-04-06T04:32:01Z-
dc.date.available2022-04-06T04:32:01Z-
dc.date.issued2018-
dc.identifier.citationJournal of Infectious Diseases, 2018, v. 217, n. 2, p. 245-256-
dc.identifier.issn0022-1899-
dc.identifier.urihttp://hdl.handle.net/10722/312030-
dc.description.abstractThe immunologic factors underlying severe influenza are poorly understood. To address this, we compared the immune responses of influenza-confirmed hospitalized individuals with severe acute respiratory illness (SARI) to those of nonhospitalized individuals with influenza-like illness (ILI). Methods. Peripheral blood lymphocytes were collected from 27 patients with ILI and 27 with SARI, at time of enrollment and then 2 weeks later. Innate and adaptive cellular immune responses were assessed by flow cytometry, and serum cytokine levels were assessed by a bead-based assay. Results. During the acute phase, SARI was associated with significantly reduced numbers of circulating myeloid dendritic cells, CD192+ monocytes, and influenza virus-specific CD8+ and CD4+ T cells as compared to ILI. By the convalescent phase, however, most SARI cases displayed continued immune activation characterized by increased numbers of CD16+ monocytes and proliferating, and influenza virus-specific, CD8+ T cells as compared to ILI cases. SARI was also associated with reduced amounts of cytokines that regulate T-cell responses (ie, interleukin 4, interleukin 13, interleukin 12, interleukin 10, and tumor necrosis factor â) and hematopoiesis (interleukin 3 and granulocyte-macrophage colony-stimulating factor) but increased amounts of a proinflammatory cytokine (tumor necrosis factor á), chemotactic cytokines (MDC, MCP-1, GRO, and fractalkine), and growth-promoting cytokines (PDGFBB/AA, VEGF, and EGF) as compared to ILI. Severe influenza cases showed a delay in the peripheral immune activation that likely led prolonged inflammation, compared with mild influenza cases.-
dc.languageeng-
dc.relation.ispartofJournal of Infectious Diseases-
dc.subjectcellular immunity-
dc.subjectcytokine.-
dc.subjectdisease severity-
dc.subjectinfection-
dc.subjectInfluenza-
dc.titleSevere Influenza Is Characterized by Prolonged Immune Activation: Results from the SHIVERS Cohort Study-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1093/infdis/jix571-
dc.identifier.pmid29112724-
dc.identifier.scopuseid_2-s2.0-85040587466-
dc.identifier.volume217-
dc.identifier.issue2-
dc.identifier.spage245-
dc.identifier.epage256-
dc.identifier.eissn1537-6613-
dc.identifier.isiWOS:000419613300012-

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