File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Identifying factors contributing to increased susceptibility to COVID-19 risk: a systematic review of Mendelian randomization studies

TitleIdentifying factors contributing to increased susceptibility to COVID-19 risk: a systematic review of Mendelian randomization studies
Authors
KeywordsCOVID-19
Mendelian randomization studies
Systematic review
Issue Date2022
Citation
International Journal of Epidemiology, 2022, v. 51 n. 4, p.1088-1105 How to Cite?
AbstractBackground: To summarize modifiable factors for coronavirus disease 2019 (COVID-19) suggested by Mendelian randomization studies. Methods: In this systematic review, we searched PubMed, EMBASE and MEDLINE, from inception to 15 November 2021, for Mendelian randomization studies in English. We selected studies that assessed associations of genetically predicted exposures with COVID-19-related outcomes (severity, hospitalization and susceptibility). Risk of bias of the included studies was evaluated based on the consideration of the three main assumptions for instrumental variable analyses. Results: We identified 700 studies through systematic search, of which 50 Mendelian randomization studies were included. Included studies have explored a wide range of socio-demographic factors, lifestyle attributes, anthropometrics and biomarkers, predisposition to diseases and druggable targets in COVID-19 risk. Mendelian randomization studies suggested that increases in smoking, obesity and inflammatory factors were associated with higher risk of COVID-19. Predisposition to ischaemic stroke, combined bipolar disorder and schizophrenia, attention-deficit and hyperactivity disorder, chronic kidney disease and idiopathic pulmonary fibrosis was potentially associated with higher COVID-19 risk. Druggable targets, such as higher protein expression of histo-blood group ABO system transferase (ABO), interleukin (IL)-6 and lower protein expression of 2′-5′ oligoadenylate synthetase 1 (OAS1) were associated with higher risk of COVID-19. There was no strong genetic evidence supporting the role of vitamin D, glycaemic traits and predisposition to cardiometabolic diseases in COVID-19 risk. Conclusion: This review summarizes modifiable factors for intervention (e.g. smoking, obesity and inflammatory factors) and proteomic signatures (e.g. OAS1 and IL-6) that could help identify drugs for treating COVID-19.
Persistent Identifierhttp://hdl.handle.net/10722/312715
ISSN
2023 Impact Factor: 6.4
2023 SCImago Journal Rankings: 2.663
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLuo, S-
dc.contributor.authorLIANG, Y-
dc.contributor.authorWong, HT-
dc.contributor.authorSchooling, CM-
dc.contributor.authorAu Yeung, SLR-
dc.date.accessioned2022-05-12T10:54:35Z-
dc.date.available2022-05-12T10:54:35Z-
dc.date.issued2022-
dc.identifier.citationInternational Journal of Epidemiology, 2022, v. 51 n. 4, p.1088-1105-
dc.identifier.issn0300-5771-
dc.identifier.urihttp://hdl.handle.net/10722/312715-
dc.description.abstractBackground: To summarize modifiable factors for coronavirus disease 2019 (COVID-19) suggested by Mendelian randomization studies. Methods: In this systematic review, we searched PubMed, EMBASE and MEDLINE, from inception to 15 November 2021, for Mendelian randomization studies in English. We selected studies that assessed associations of genetically predicted exposures with COVID-19-related outcomes (severity, hospitalization and susceptibility). Risk of bias of the included studies was evaluated based on the consideration of the three main assumptions for instrumental variable analyses. Results: We identified 700 studies through systematic search, of which 50 Mendelian randomization studies were included. Included studies have explored a wide range of socio-demographic factors, lifestyle attributes, anthropometrics and biomarkers, predisposition to diseases and druggable targets in COVID-19 risk. Mendelian randomization studies suggested that increases in smoking, obesity and inflammatory factors were associated with higher risk of COVID-19. Predisposition to ischaemic stroke, combined bipolar disorder and schizophrenia, attention-deficit and hyperactivity disorder, chronic kidney disease and idiopathic pulmonary fibrosis was potentially associated with higher COVID-19 risk. Druggable targets, such as higher protein expression of histo-blood group ABO system transferase (ABO), interleukin (IL)-6 and lower protein expression of 2′-5′ oligoadenylate synthetase 1 (OAS1) were associated with higher risk of COVID-19. There was no strong genetic evidence supporting the role of vitamin D, glycaemic traits and predisposition to cardiometabolic diseases in COVID-19 risk. Conclusion: This review summarizes modifiable factors for intervention (e.g. smoking, obesity and inflammatory factors) and proteomic signatures (e.g. OAS1 and IL-6) that could help identify drugs for treating COVID-19.-
dc.languageeng-
dc.relation.ispartofInternational Journal of Epidemiology-
dc.subjectCOVID-19-
dc.subjectMendelian randomization studies-
dc.subjectSystematic review-
dc.titleIdentifying factors contributing to increased susceptibility to COVID-19 risk: a systematic review of Mendelian randomization studies-
dc.typeArticle-
dc.identifier.emailLuo, S: aprilluo@hku.hk-
dc.identifier.emailWong, HT: thtwong@hku.hk-
dc.identifier.emailSchooling, CM: cms1@hkucc.hku.hk-
dc.identifier.emailAu Yeung, SLR: ayslryan@hku.hk-
dc.identifier.authoritySchooling, CM=rp00504-
dc.identifier.authorityAu Yeung, SLR=rp02224-
dc.identifier.doi10.1093/ije/dyac076-
dc.identifier.pmid35445260-
dc.identifier.pmcidPMC9047195-
dc.identifier.scopuseid_2-s2.0-85136223310-
dc.identifier.hkuros332993-
dc.identifier.volume51-
dc.identifier.issue4-
dc.identifier.spage1088-
dc.identifier.epage1105-
dc.identifier.isiWOS:000784721300001-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats