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Article: FACI Is a Novel CREB-H–Induced Protein That Inhibits Intestinal Lipid Absorption and Reverses Diet-Induced Obesity

TitleFACI Is a Novel CREB-H–Induced Protein That Inhibits Intestinal Lipid Absorption and Reverses Diet-Induced Obesity
Authors
KeywordsLipid Homeostasis
Phospholipid-Binding Protein
Recycling Endosome
Intestinal Fat Absorption
Metabolic Syndrome
Issue Date2022
PublisherElsevier: Open Access Journals. The Journal's web site is located at https://www.cmghjournal.org/
Citation
Cellular and Molecular Gastroenterology and Hepatology, 2022, v. 13 n. 5, p. 1365-1391 How to Cite?
AbstractCREB-H is a key regulator of lipid homeostasis. We identified fasting- and CREB-H–induced protein as a CREB-H–induced membrane and endosomal protein that binds to phospholipids. Using Faci-deficient mice, we defined a new function of fasting- and CREB-H–induced protein in the inhibition of intestinal lipid absorption and reversal of obesity.
Persistent Identifierhttp://hdl.handle.net/10722/312929
ISSN
2021 Impact Factor: 8.797
2020 SCImago Journal Rankings: 3.417
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCheng, Y-
dc.contributor.authorKang, X-
dc.contributor.authorCheng, T-
dc.contributor.authorYe, ZW-
dc.contributor.authorTipoe, GL-
dc.contributor.authorYu, C-
dc.contributor.authorWong, CM-
dc.contributor.authorLiu, B-
dc.contributor.authorChan, CP-
dc.contributor.authorJin, DY-
dc.date.accessioned2022-05-21T11:53:37Z-
dc.date.available2022-05-21T11:53:37Z-
dc.date.issued2022-
dc.identifier.citationCellular and Molecular Gastroenterology and Hepatology, 2022, v. 13 n. 5, p. 1365-1391-
dc.identifier.issn2352-345X-
dc.identifier.urihttp://hdl.handle.net/10722/312929-
dc.description.abstractCREB-H is a key regulator of lipid homeostasis. We identified fasting- and CREB-H–induced protein as a CREB-H–induced membrane and endosomal protein that binds to phospholipids. Using Faci-deficient mice, we defined a new function of fasting- and CREB-H–induced protein in the inhibition of intestinal lipid absorption and reversal of obesity.-
dc.languageeng-
dc.publisherElsevier: Open Access Journals. The Journal's web site is located at https://www.cmghjournal.org/-
dc.relation.ispartofCellular and Molecular Gastroenterology and Hepatology-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectLipid Homeostasis-
dc.subjectPhospholipid-Binding Protein-
dc.subjectRecycling Endosome-
dc.subjectIntestinal Fat Absorption-
dc.subjectMetabolic Syndrome-
dc.titleFACI Is a Novel CREB-H–Induced Protein That Inhibits Intestinal Lipid Absorption and Reverses Diet-Induced Obesity-
dc.typeArticle-
dc.identifier.emailCheng, Y: yuncheng@hku.hk-
dc.identifier.emailYe, ZW: zwye@hku.hk-
dc.identifier.emailTipoe, GL: tgeorge@hku.hk-
dc.identifier.emailYu, C: chyu1@hku.hk-
dc.identifier.emailChan, CP: cpchan@hku.hk-
dc.identifier.emailJin, DY: dyjin@hku.hk-
dc.identifier.authorityTipoe, GL=rp00371-
dc.identifier.authorityYu, C=rp01930-
dc.identifier.authorityJin, DY=rp00452-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1016/j.jcmgh.2022.01.017-
dc.identifier.pmid35093589-
dc.identifier.pmcidPMC8938335-
dc.identifier.scopuseid_2-s2.0-85126628685-
dc.identifier.hkuros333103-
dc.identifier.volume13-
dc.identifier.issue5-
dc.identifier.spage1365-
dc.identifier.epage1391-
dc.identifier.isiWOS:000986860300001-
dc.publisher.placeUnited States-

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