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Article: Use of Medaka in toxicity testing
Title | Use of Medaka in toxicity testing |
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Authors | |
Keywords | Endocrine disruption Hepatotoxicity Medaka Neurotoxicity |
Issue Date | 2009 |
Citation | Current Protocols in Toxicology, 2009, n. SUPPL. 39 How to Cite? |
Abstract | Small aquarium fishes are increasingly used as animal models, and one of these, the Japanese Medaka (Oryzias latipes), is frequently utilized for toxicity testing. While these vertebrates have many similarities with their terrestrial counterparts, there are differences that must be considered if these organisms are to be used to their highest potential. Commonly, testing may employ either the developing embryo or adults; both are easy to use and work with. To illustrate the utility and breadth of toxicity testing possible using medaka fish, we present protocols for assessing neurotoxicity in developing embryos, evaluating toxicant effects on sexual phenotype after treatment with endocrine-disrupting chemicals by sexual genotyping, and measuring hepatotoxicity in adult fish after treatment with a model hepatotoxicant. The methods run the gamut from immunohistology through PCR to basic histological techniques. © 2009 by John Wiley & Sons, Inc. |
Persistent Identifier | http://hdl.handle.net/10722/313025 |
ISSN | 2023 SCImago Journal Rankings: 0.115 |
PubMed Central ID |
DC Field | Value | Language |
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dc.contributor.author | Padilla, Stephanie | - |
dc.contributor.author | Cowden, John | - |
dc.contributor.author | Hinton, David E. | - |
dc.contributor.author | Yuen, Bonny | - |
dc.contributor.author | Law, Sheran | - |
dc.contributor.author | Kullman, Seth W. | - |
dc.contributor.author | Johnson, Rodney | - |
dc.contributor.author | Hardman, Ronald C. | - |
dc.contributor.author | Flynn, Kevin | - |
dc.contributor.author | Au, Doris W.T. | - |
dc.date.accessioned | 2022-05-26T07:00:07Z | - |
dc.date.available | 2022-05-26T07:00:07Z | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | Current Protocols in Toxicology, 2009, n. SUPPL. 39 | - |
dc.identifier.issn | 1934-9254 | - |
dc.identifier.uri | http://hdl.handle.net/10722/313025 | - |
dc.description.abstract | Small aquarium fishes are increasingly used as animal models, and one of these, the Japanese Medaka (Oryzias latipes), is frequently utilized for toxicity testing. While these vertebrates have many similarities with their terrestrial counterparts, there are differences that must be considered if these organisms are to be used to their highest potential. Commonly, testing may employ either the developing embryo or adults; both are easy to use and work with. To illustrate the utility and breadth of toxicity testing possible using medaka fish, we present protocols for assessing neurotoxicity in developing embryos, evaluating toxicant effects on sexual phenotype after treatment with endocrine-disrupting chemicals by sexual genotyping, and measuring hepatotoxicity in adult fish after treatment with a model hepatotoxicant. The methods run the gamut from immunohistology through PCR to basic histological techniques. © 2009 by John Wiley & Sons, Inc. | - |
dc.language | eng | - |
dc.relation.ispartof | Current Protocols in Toxicology | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Endocrine disruption | - |
dc.subject | Hepatotoxicity | - |
dc.subject | Medaka | - |
dc.subject | Neurotoxicity | - |
dc.title | Use of Medaka in toxicity testing | - |
dc.type | Article | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1002/0471140856.tx0110s39 | - |
dc.identifier.pmid | 20922755 | - |
dc.identifier.pmcid | PMC4300524 | - |
dc.identifier.scopus | eid_2-s2.0-61749092306 | - |
dc.identifier.issue | SUPPL. 39 | - |
dc.identifier.eissn | 1934-9262 | - |