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Article: Identification of a Novel Inhibitor of Catabolite Control Protein A from Staphylococcus aureus

TitleIdentification of a Novel Inhibitor of Catabolite Control Protein A from Staphylococcus aureus
Authors
Huang, QiZhang, ZheminLi, HuinanGuo, YuLiao, XiangwenLi, HongyanZhou, HuihaoXia, Wei
Keywordscatabolite control protein A
inhibitor
Staphylococcus aureus
synergistic effect
Issue Date2020
Citation
ACS Infectious Diseases, 2020, v. 6, n. 3, p. 347-354 How to Cite?
DOI: http://dx.doi.org/10.1021/acsinfecdis.9b00465
AbstractCatabolite control protein A is a highly conserved transcriptional regulator in Gram-positive bacteria. Herein, we report a specific small-molecule inhibitor of Staphylococcus aureus catabolite control protein A (SaCcpA). The compound abrogates the regulatory function of SaCcpA, resulting in decreased expression of an S. aureus major cytotoxin, α-hemolysin. The observed synergism between the compound and antibiotics against S. aureus suggests its potential application in a combination therapy to combat antimicrobial resistance.
Persistent Identifierhttp://hdl.handle.net/10722/313029
ISI Accession Number ID
WOS:000526415000002

 

DC FieldValueLanguage
dc.contributor.authorHuang, Qi-
dc.contributor.authorZhang, Zhemin-
dc.contributor.authorLi, Huinan-
dc.contributor.authorGuo, Yu-
dc.contributor.authorLiao, Xiangwen-
dc.contributor.authorLi, Hongyan-
dc.contributor.authorZhou, Huihao-
dc.contributor.authorXia, Wei-
dc.date.accessioned2022-05-26T07:00:07Z-
dc.date.available2022-05-26T07:00:07Z-
dc.date.issued2020-
dc.identifier.citationACS Infectious Diseases, 2020, v. 6, n. 3, p. 347-354-
dc.identifier.urihttp://hdl.handle.net/10722/313029-
dc.description.abstractCatabolite control protein A is a highly conserved transcriptional regulator in Gram-positive bacteria. Herein, we report a specific small-molecule inhibitor of Staphylococcus aureus catabolite control protein A (SaCcpA). The compound abrogates the regulatory function of SaCcpA, resulting in decreased expression of an S. aureus major cytotoxin, α-hemolysin. The observed synergism between the compound and antibiotics against S. aureus suggests its potential application in a combination therapy to combat antimicrobial resistance.-
dc.languageeng-
dc.relation.ispartofACS Infectious Diseases-
dc.subjectcatabolite control protein A-
dc.subjectinhibitor-
dc.subjectStaphylococcus aureus-
dc.subjectsynergistic effect-
dc.titleIdentification of a Novel Inhibitor of Catabolite Control Protein A from Staphylococcus aureus-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/acsinfecdis.9b00465-
dc.identifier.pmid32027109-
dc.identifier.scopuseid_2-s2.0-85081945239-
dc.identifier.volume6-
dc.identifier.issue3-
dc.identifier.spage347-
dc.identifier.epage354-
dc.identifier.eissn2373-8227-
dc.identifier.isiWOS:000526415000002-

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