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Article: SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters

TitleSARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters
Authors
Issue Date2022
PublisherNature Research: Fully open access journals. The Journal's web site is located at http://www.nature.com/ncomms/index.html
Citation
Nature Communications, 2022, v. 13 How to Cite?
AbstractExtrapulmonary complications of different organ systems have been increasingly recognized in patients with severe or chronic Coronavirus Disease 2019 (COVID-19). However, limited information on the skeletal complications of COVID-19 is known, even though inflammatory diseases of the respiratory tract have been known to perturb bone metabolism and cause pathological bone loss. In this study, we characterize the effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on bone metabolism in an established golden Syrian hamster model for COVID-19. SARS-CoV-2 causes significant multifocal loss of bone trabeculae in the long bones and lumbar vertebrae of all infected hamsters. Moreover, we show that the bone loss is associated with SARS-CoV-2-induced cytokine dysregulation, as the circulating pro-inflammatory cytokines not only upregulate osteoclastic differentiation in bone tissues, but also trigger an amplified pro-inflammatory cascade in the skeletal tissues to augment their pro-osteoclastogenesis effect. Our findings suggest that pathological bone loss may be a neglected complication which warrants more extensive investigations during the long-term follow-up of COVID-19 patients. The benefits of potential prophylactic and therapeutic interventions against pathological bone loss should be further evaluated.
Persistent Identifierhttp://hdl.handle.net/10722/313265
ISSN
2023 Impact Factor: 14.7
2023 SCImago Journal Rankings: 4.887
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorQiao, WW-
dc.contributor.authorLau, HE-
dc.contributor.authorXie, H-
dc.contributor.authorPoon, KM-
dc.contributor.authorChan, CCS-
dc.contributor.authorChu, H-
dc.contributor.authorYuan, S-
dc.contributor.authorYuen, TTT-
dc.contributor.authorChik, KKH-
dc.contributor.authorTsang, OL-
dc.contributor.authorChan, CYC-
dc.contributor.authorCai, J-P-
dc.contributor.authorLuo, C-
dc.contributor.authorYuen, KY-
dc.contributor.authorCheung, KMC-
dc.contributor.authorChan, JFW-
dc.contributor.authorYeung, KWK-
dc.date.accessioned2022-06-06T05:48:31Z-
dc.date.available2022-06-06T05:48:31Z-
dc.date.issued2022-
dc.identifier.citationNature Communications, 2022, v. 13-
dc.identifier.issn2041-1723-
dc.identifier.urihttp://hdl.handle.net/10722/313265-
dc.description.abstractExtrapulmonary complications of different organ systems have been increasingly recognized in patients with severe or chronic Coronavirus Disease 2019 (COVID-19). However, limited information on the skeletal complications of COVID-19 is known, even though inflammatory diseases of the respiratory tract have been known to perturb bone metabolism and cause pathological bone loss. In this study, we characterize the effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on bone metabolism in an established golden Syrian hamster model for COVID-19. SARS-CoV-2 causes significant multifocal loss of bone trabeculae in the long bones and lumbar vertebrae of all infected hamsters. Moreover, we show that the bone loss is associated with SARS-CoV-2-induced cytokine dysregulation, as the circulating pro-inflammatory cytokines not only upregulate osteoclastic differentiation in bone tissues, but also trigger an amplified pro-inflammatory cascade in the skeletal tissues to augment their pro-osteoclastogenesis effect. Our findings suggest that pathological bone loss may be a neglected complication which warrants more extensive investigations during the long-term follow-up of COVID-19 patients. The benefits of potential prophylactic and therapeutic interventions against pathological bone loss should be further evaluated.-
dc.languageeng-
dc.publisherNature Research: Fully open access journals. The Journal's web site is located at http://www.nature.com/ncomms/index.html-
dc.relation.ispartofNature Communications-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleSARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters-
dc.typeArticle-
dc.identifier.emailQiao, WW: drqiao@hku.hk-
dc.identifier.emailPoon, KM: vinpoon@hku.hk-
dc.identifier.emailChan, CCS: cschan@hku.hk-
dc.identifier.emailChu, H: hinchu@hku.hk-
dc.identifier.emailYuan, S: yuansf@hku.hk-
dc.identifier.emailChik, KKH: kennchik@hku.hk-
dc.identifier.emailTsang, OL: oltsang@hku.hk-
dc.identifier.emailChan, CYC: cyc415@hku.hk-
dc.identifier.emailCai, J-P: caijuice@hku.hk-
dc.identifier.emailLuo, C: cuiting@hku.hk-
dc.identifier.emailYuen, KY: kyyuen@hkucc.hku.hk-
dc.identifier.emailCheung, KMC: ken-cheung@hku.hk, cheungmc@hku.hk-
dc.identifier.emailChan, JFW: jaspchan@gmail.com-
dc.identifier.emailYeung, KWK: wkkyeung@hku.hk-
dc.identifier.authorityQiao, WW=rp02919-
dc.identifier.authorityChu, H=rp02125-
dc.identifier.authorityYuan, S=rp02640-
dc.identifier.authorityYuen, KY=rp00366-
dc.identifier.authorityCheung, KMC=rp00387-
dc.identifier.authorityChan, JFW=rp01736-
dc.identifier.authorityYeung, KWK=rp00309-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1038/s41467-022-30195-w-
dc.identifier.pmid35534483-
dc.identifier.pmcidPMC9085785-
dc.identifier.hkuros333374-
dc.identifier.volume13-
dc.identifier.isiWOS:000792848500026-
dc.publisher.placeUnited Kingdom-

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