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Article: Biomimicking Bone–Implant Interface Facilitates the Bioadaption of a New Degradable Magnesium Alloy to the Bone Tissue Microenvironment

TitleBiomimicking Bone–Implant Interface Facilitates the Bioadaption of a New Degradable Magnesium Alloy to the Bone Tissue Microenvironment
Authors
Issue Date2021
PublisherWiley Open Access. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2198-3844
Citation
Advanced Science, 2021, v. 8 n. 23, p. 2102035 How to Cite?
AbstractThe most critical factor determining the success of biodegradable bone implants is the host tissue response, which greatly depends on their degradation behaviors. Here, a new magnesium-based implant, namely magnesium–silicon–calcium (Mg–0.2Si–1.0Ca) alloy, that coordinates its biodegradation along with the bone regenerative process via a self-assembled, multilayered bone–implant interface is designed. At first, its rapid biocorrosion contributes to a burst release of Mg2+, leading to a pro-osteogenic immune microenvironment in bone. Meanwhile, with the simultaneous intervention of Ca and Si in the secondary phases of the new alloy, a hierarchical layered calcified matrix is rapidly formed at the degrading interface that favored the subsequent bone mineralization. In contrast, pure Mg or Mg–0.2Si alloy without the development of this interface at the beginning will unavoidably induce detrimental bone loss. Hence, it is believed this biomimicking interface justifies its bioadaptability in which it can modulate its degradation in vivo and accelerate bone mineralization.
Persistent Identifierhttp://hdl.handle.net/10722/313304
ISSN
2023 Impact Factor: 14.3
2023 SCImago Journal Rankings: 3.914
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, W-
dc.contributor.authorQiao, WW-
dc.contributor.authorLiu, X-
dc.contributor.authorBian, D-
dc.contributor.authorShen, D-
dc.contributor.authorZheng, Y-
dc.contributor.authorWu, J-
dc.contributor.authorKwan, KYH-
dc.contributor.authorWong, TM-
dc.contributor.authorCheung, KMC-
dc.contributor.authorYeung, KWK-
dc.date.accessioned2022-06-06T05:49:07Z-
dc.date.available2022-06-06T05:49:07Z-
dc.date.issued2021-
dc.identifier.citationAdvanced Science, 2021, v. 8 n. 23, p. 2102035-
dc.identifier.issn2198-3844-
dc.identifier.urihttp://hdl.handle.net/10722/313304-
dc.description.abstractThe most critical factor determining the success of biodegradable bone implants is the host tissue response, which greatly depends on their degradation behaviors. Here, a new magnesium-based implant, namely magnesium–silicon–calcium (Mg–0.2Si–1.0Ca) alloy, that coordinates its biodegradation along with the bone regenerative process via a self-assembled, multilayered bone–implant interface is designed. At first, its rapid biocorrosion contributes to a burst release of Mg2+, leading to a pro-osteogenic immune microenvironment in bone. Meanwhile, with the simultaneous intervention of Ca and Si in the secondary phases of the new alloy, a hierarchical layered calcified matrix is rapidly formed at the degrading interface that favored the subsequent bone mineralization. In contrast, pure Mg or Mg–0.2Si alloy without the development of this interface at the beginning will unavoidably induce detrimental bone loss. Hence, it is believed this biomimicking interface justifies its bioadaptability in which it can modulate its degradation in vivo and accelerate bone mineralization.-
dc.languageeng-
dc.publisherWiley Open Access. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2198-3844-
dc.relation.ispartofAdvanced Science-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleBiomimicking Bone–Implant Interface Facilitates the Bioadaption of a New Degradable Magnesium Alloy to the Bone Tissue Microenvironment-
dc.typeArticle-
dc.identifier.emailQiao, WW: drqiao@hku.hk-
dc.identifier.emailZheng, Y: yfzheng@pku.edu.cn-
dc.identifier.emailWong, TM: wongtm@hku.hk-
dc.identifier.emailCheung, KMC: cheungmc@hku.hk-
dc.identifier.emailYeung, KWK: wkkyeung@hku.hk-
dc.identifier.authorityQiao, WW=rp02919-
dc.identifier.authorityWong, TM=rp01689-
dc.identifier.authorityCheung, KMC=rp00387-
dc.identifier.authorityYeung, KWK=rp00309-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1002/advs.202102035-
dc.identifier.hkuros333375-
dc.identifier.volume8-
dc.identifier.issue23-
dc.identifier.spage2102035-
dc.identifier.epage2102035-
dc.identifier.isiWOS:000712090000001-
dc.publisher.placeGermany-

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