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Article: Fusion Peptide-Engineered Polyetheretherketone Implants with Photo-Assisted Anti-Pathogen and Enhanced Angiogenesis for in vivo Osseointegrative Fixation

TitleFusion Peptide-Engineered Polyetheretherketone Implants with Photo-Assisted Anti-Pathogen and Enhanced Angiogenesis for in vivo Osseointegrative Fixation
Authors
KeywordsOrthopedic Implant
Polyetheretherketone
Antibacterial
Angiogenesis
Osseointegration
Issue Date2022
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/cej
Citation
Chemical Engineering Journal, 2022, v. 446 n. pt. 5, article no. 137453 How to Cite?
AbstractOwing to its superior mechanical and physicochemical characteristics, polyetheretherketone (PEEK) is considered a potent orthopedic material. Yet, poor bactericidal, osseointegrative and angiogenic properties of bioinert PEEK collectively hamper its clinical adoption. Herein, we present a strategy for developing multifunctional hierarchical coatings bearing a synthetic fusion peptide and polydopamine/silver nanoparticles (pDA/AgNPs) bio-heterojunctions (bio-HJs), in an attempt to empower PEEK with triple-modal abilities, which prevents bacterial infection, enhances ossification and promotes re-vascularization for physiological osseointegrative fixation. By harnessing the adhesion of bioinspired pDA, AgNPs are facilely immobilized onto peripheral surface and incorporated into interior cavity of micro/nano-porous sulfonated PEEK (SP) to form hierarchical pDA/AgNPs heterostructures. The bio-HJs coatings exhibit robust and repeatable bacteria-eradicating ability, assisted by near-infrared illumination, due to the synergistic effects of the metal ion/photothermal therapy. The fusion peptide-engineered PEEK exhibits osteogenesis activity in terms of promoting osteoblast proliferation, spreading, boosting the synthesis and secretion of osteogenesis-related genes. Besides, the fusion peptide-engineered PEEK also has the ability to promote HUVECs growth, reproduction, and tube formation, facilitating the synthesis and secretion of angiogenesis-associated genes. Moreover, the results of the in vivo experiments further corroborate the in vivo osteointegration and angiogenic abilities of materials. Expectantly, the multifunctional coatings with the presented triple-therapeutic effects represent a prospective clinical solution to address the current clinical challenges associated with the use of PEEK implants.
Persistent Identifierhttp://hdl.handle.net/10722/313492
ISSN
2023 Impact Factor: 13.3
2023 SCImago Journal Rankings: 2.852
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHe, ST-
dc.contributor.authorDuan, C-
dc.contributor.authorWang, S-
dc.contributor.authorYu, Y-
dc.contributor.authorChan, YK-
dc.contributor.authorShi, X-
dc.contributor.authorHuang, J-
dc.contributor.authorWang, ST-
dc.contributor.authorPeng, S-
dc.contributor.authorDeng, Y-
dc.date.accessioned2022-06-17T06:47:13Z-
dc.date.available2022-06-17T06:47:13Z-
dc.date.issued2022-
dc.identifier.citationChemical Engineering Journal, 2022, v. 446 n. pt. 5, article no. 137453-
dc.identifier.issn1385-8947-
dc.identifier.urihttp://hdl.handle.net/10722/313492-
dc.description.abstractOwing to its superior mechanical and physicochemical characteristics, polyetheretherketone (PEEK) is considered a potent orthopedic material. Yet, poor bactericidal, osseointegrative and angiogenic properties of bioinert PEEK collectively hamper its clinical adoption. Herein, we present a strategy for developing multifunctional hierarchical coatings bearing a synthetic fusion peptide and polydopamine/silver nanoparticles (pDA/AgNPs) bio-heterojunctions (bio-HJs), in an attempt to empower PEEK with triple-modal abilities, which prevents bacterial infection, enhances ossification and promotes re-vascularization for physiological osseointegrative fixation. By harnessing the adhesion of bioinspired pDA, AgNPs are facilely immobilized onto peripheral surface and incorporated into interior cavity of micro/nano-porous sulfonated PEEK (SP) to form hierarchical pDA/AgNPs heterostructures. The bio-HJs coatings exhibit robust and repeatable bacteria-eradicating ability, assisted by near-infrared illumination, due to the synergistic effects of the metal ion/photothermal therapy. The fusion peptide-engineered PEEK exhibits osteogenesis activity in terms of promoting osteoblast proliferation, spreading, boosting the synthesis and secretion of osteogenesis-related genes. Besides, the fusion peptide-engineered PEEK also has the ability to promote HUVECs growth, reproduction, and tube formation, facilitating the synthesis and secretion of angiogenesis-associated genes. Moreover, the results of the in vivo experiments further corroborate the in vivo osteointegration and angiogenic abilities of materials. Expectantly, the multifunctional coatings with the presented triple-therapeutic effects represent a prospective clinical solution to address the current clinical challenges associated with the use of PEEK implants.-
dc.languageeng-
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/cej-
dc.relation.ispartofChemical Engineering Journal-
dc.subjectOrthopedic Implant-
dc.subjectPolyetheretherketone-
dc.subjectAntibacterial-
dc.subjectAngiogenesis-
dc.subjectOsseointegration-
dc.titleFusion Peptide-Engineered Polyetheretherketone Implants with Photo-Assisted Anti-Pathogen and Enhanced Angiogenesis for in vivo Osseointegrative Fixation-
dc.typeArticle-
dc.identifier.emailChan, YK: josephyk@connect.hku.hk-
dc.identifier.authorityChan, YK=rp02536-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.cej.2022.137453-
dc.identifier.hkuros333508-
dc.identifier.volume446-
dc.identifier.issuept. 5-
dc.identifier.spagearticle no. 137453-
dc.identifier.epagearticle no. 137453-
dc.identifier.isiWOS:000817777300002-
dc.publisher.placeNetherlands-

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