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Article: MyoD is a tumor suppressor gene in medulloblastoma

TitleMyoD is a tumor suppressor gene in medulloblastoma
Authors
Issue Date2013
Citation
Cancer Research, 2013, v. 73, n. 22, p. 6828-6837 How to Cite?
AbstractWhile medulloblastoma, a pediatric tumor of the cerebellum, is characterized by aberrations in developmental pathways, the majority of genetic determinants remain unknown. An unbiased Sleeping Beauty transposon screen revealed MyoD as a putative medulloblastoma tumor suppressor. This was unexpected, as MyoD is a muscle differentiation factor and not previously known to be expressed in cerebellum or medulloblastoma. In response to deletion of one allele of MyoD, two other Sonic hedgehog-driven mouse medulloblastoma models showed accelerated tumor formation and death, confirming MyoD as a tumor suppressor in these models. In normal cerebellum, MyoD was expressed in the proliferating granule neuron progenitors that are thought to be precursors to medulloblastoma. Similar to some other tumor suppressors that are induced in cancer, MyoD was expressed in proliferating medulloblastoma cells in three mouse models and in human medulloblastoma cases. This suggests that although expression of MyoD in a proliferating tumor is insufficient to prevent tumor progression, its expression in the cerebellum hinders medulloblastoma genesis. ©2013 AACR.
Persistent Identifierhttp://hdl.handle.net/10722/313959
ISSN
2023 Impact Factor: 12.5
2023 SCImago Journal Rankings: 3.468
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorDey, Joyoti-
dc.contributor.authorDubuc, Adrian M.-
dc.contributor.authorPedro, Kyle D.-
dc.contributor.authorThirstrup, Derek-
dc.contributor.authorMecham, Brig-
dc.contributor.authorNorthcott, Paul A.-
dc.contributor.authorWu, Xiaochong-
dc.contributor.authorShih, David-
dc.contributor.authorTapscott, Stephen J.-
dc.contributor.authorLeBlanc, Michael-
dc.contributor.authorTaylor, Michael D.-
dc.contributor.authorOlson, James M.-
dc.date.accessioned2022-07-06T11:28:37Z-
dc.date.available2022-07-06T11:28:37Z-
dc.date.issued2013-
dc.identifier.citationCancer Research, 2013, v. 73, n. 22, p. 6828-6837-
dc.identifier.issn0008-5472-
dc.identifier.urihttp://hdl.handle.net/10722/313959-
dc.description.abstractWhile medulloblastoma, a pediatric tumor of the cerebellum, is characterized by aberrations in developmental pathways, the majority of genetic determinants remain unknown. An unbiased Sleeping Beauty transposon screen revealed MyoD as a putative medulloblastoma tumor suppressor. This was unexpected, as MyoD is a muscle differentiation factor and not previously known to be expressed in cerebellum or medulloblastoma. In response to deletion of one allele of MyoD, two other Sonic hedgehog-driven mouse medulloblastoma models showed accelerated tumor formation and death, confirming MyoD as a tumor suppressor in these models. In normal cerebellum, MyoD was expressed in the proliferating granule neuron progenitors that are thought to be precursors to medulloblastoma. Similar to some other tumor suppressors that are induced in cancer, MyoD was expressed in proliferating medulloblastoma cells in three mouse models and in human medulloblastoma cases. This suggests that although expression of MyoD in a proliferating tumor is insufficient to prevent tumor progression, its expression in the cerebellum hinders medulloblastoma genesis. ©2013 AACR.-
dc.languageeng-
dc.relation.ispartofCancer Research-
dc.titleMyoD is a tumor suppressor gene in medulloblastoma-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1158/0008-5472.CAN-13-0730-T-
dc.identifier.pmid24092238-
dc.identifier.pmcidPMC4014678-
dc.identifier.scopuseid_2-s2.0-84888337722-
dc.identifier.volume73-
dc.identifier.issue22-
dc.identifier.spage6828-
dc.identifier.epage6837-
dc.identifier.eissn1538-7445-
dc.identifier.isiWOS:000327321700027-

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