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Article: Efavirenz use and neurocognitive performance among older people living with HIV who were on antiretroviral therapy

TitleEfavirenz use and neurocognitive performance among older people living with HIV who were on antiretroviral therapy
Authors
KeywordsChina
Efavirenz use
Neurocognitive performance
older people living with HIV
Issue Date2020
Citation
AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV, 2020, v. 32, n. 1, p. 12-20 How to Cite?
AbstractThis study was to compare global and domain-specific neurocognitive performance between older people living with HIV (PLWH) taking/not taking efavirenz (EFV) and HIV-negative controls. A cross-sectional study was conducted in Yongzhou city, China. All PLWH older than 50 years listed on the registry of Centres for Disease Control and Prevention were invited to join the study. Frequency matching was used to sample HIV-negative controls according to the distribution of age, sex, and years of formal education of older PLWH. A total of 308 older PLWH and 350 HIV-negative controls completed the face-to-face interview and neurocognitive assessment using the comprehensive neuropsychological test battery. After adjusting for significant confounders, older PLWH taking EFV showed poorer performance in memory (p = 0.020), verbal fluency (p = 0.002), and poorer global neurocognitive performance (p = 0.032) than those without EFV use. Compared to HIV-negative controls, older PLWH taking EFV had poorer performance in all neurocognitive domains (p values: <0.001–0.003) and poorer global neurocognitive performance (p < 0.001). Similar trends were observed when comparing older PLWH without using EFV versus HIV-negative controls, with the exception of verbal fluency (p = 0.560). Health care workers should monitor the neuropsychological performance of older PLWH, epically those who were taking EFV. Longitudinal studies are warranted.
Persistent Identifierhttp://hdl.handle.net/10722/313978
ISSN
2023 Impact Factor: 1.2
2023 SCImago Journal Rankings: 0.696
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorQin, Pei-
dc.contributor.authorHe, Jianmei-
dc.contributor.authorWang, Zixin-
dc.contributor.authorChen, Xi-
dc.contributor.authorLi, Jinghua-
dc.contributor.authorFung, Ada Wai Tung-
dc.contributor.authorJiang, Hui-
dc.contributor.authorChen, Jie-
dc.contributor.authorWong, Anna-
dc.contributor.authorLau, Joseph Tak Fai-
dc.date.accessioned2022-07-06T11:28:41Z-
dc.date.available2022-07-06T11:28:41Z-
dc.date.issued2020-
dc.identifier.citationAIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV, 2020, v. 32, n. 1, p. 12-20-
dc.identifier.issn0954-0121-
dc.identifier.urihttp://hdl.handle.net/10722/313978-
dc.description.abstractThis study was to compare global and domain-specific neurocognitive performance between older people living with HIV (PLWH) taking/not taking efavirenz (EFV) and HIV-negative controls. A cross-sectional study was conducted in Yongzhou city, China. All PLWH older than 50 years listed on the registry of Centres for Disease Control and Prevention were invited to join the study. Frequency matching was used to sample HIV-negative controls according to the distribution of age, sex, and years of formal education of older PLWH. A total of 308 older PLWH and 350 HIV-negative controls completed the face-to-face interview and neurocognitive assessment using the comprehensive neuropsychological test battery. After adjusting for significant confounders, older PLWH taking EFV showed poorer performance in memory (p = 0.020), verbal fluency (p = 0.002), and poorer global neurocognitive performance (p = 0.032) than those without EFV use. Compared to HIV-negative controls, older PLWH taking EFV had poorer performance in all neurocognitive domains (p values: <0.001–0.003) and poorer global neurocognitive performance (p < 0.001). Similar trends were observed when comparing older PLWH without using EFV versus HIV-negative controls, with the exception of verbal fluency (p = 0.560). Health care workers should monitor the neuropsychological performance of older PLWH, epically those who were taking EFV. Longitudinal studies are warranted.-
dc.languageeng-
dc.relation.ispartofAIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV-
dc.subjectChina-
dc.subjectEfavirenz use-
dc.subjectNeurocognitive performance-
dc.subjectolder people living with HIV-
dc.titleEfavirenz use and neurocognitive performance among older people living with HIV who were on antiretroviral therapy-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1080/09540121.2019.1622645-
dc.identifier.pmid31142146-
dc.identifier.scopuseid_2-s2.0-85067655236-
dc.identifier.volume32-
dc.identifier.issue1-
dc.identifier.spage12-
dc.identifier.epage20-
dc.identifier.eissn1360-0451-
dc.identifier.isiWOS:000471413300001-

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