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Article: A Mediator-Free Electroenzymatic Sensing Methodology to Mitigate Ionic and Electroactive Interferents' Effects for Reliable Wearable Metabolite and Nutrient Monitoring

TitleA Mediator-Free Electroenzymatic Sensing Methodology to Mitigate Ionic and Electroactive Interferents' Effects for Reliable Wearable Metabolite and Nutrient Monitoring
Authors
Keywordselectrochemical sensors
mediator-free sensors
metabolite monitoring
nutrient monitoring
wearable biomarker sensors
Issue Date2020
Citation
Advanced Functional Materials, 2020, v. 30, n. 10, article no. 1908507 How to Cite?
AbstractWearable electroenzymatic sensors enable monitoring of clinically informative biomolecules in epidermally retrievable biofluids. Conventional wearable enzymatic sensors utilize Prussian Blue (a redox mediator) to achieve selectivity against electroactive interferents. However, the use of Prussian Blue presents fundamental challenges including: 1) the susceptibility of the sensor response to dynamic concentration variation of ionic species and 2) the poor operational stability due to the degradation of its framework. As an alternative wearable electroenzymatic sensor development methodology to bypass the aforementioned limitations, a mediator-free sensing interface is devised, comprising of a coupled platinum nanoparticle/multiwall carbon nanotube layer and a permselective membrane. The interface is adapted to develop sensors targeting glucose, lactate, and choline (as examples of informative metabolites and nutrients), showing high degrees of sensitivity, selectivity (against a wide panel of naturally present and diverse interfering species), stability (<6.5% signal drift over 20 h operation), and reliability of sensing operation in sweat samples. By integration within a readout board, a wireless sample-to-answer system is realized for on-body sweat biomarker analysis. This methodology can be adapted to target a wide panel of biomarkers in various biofluids, introducing a new sensor development direction for personal health monitoring.
Persistent Identifierhttp://hdl.handle.net/10722/313983
ISSN
2023 Impact Factor: 18.5
2023 SCImago Journal Rankings: 5.496
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCheng, Xuanbing-
dc.contributor.authorWang, Bo-
dc.contributor.authorZhao, Yichao-
dc.contributor.authorHojaiji, Hannaneh-
dc.contributor.authorLin, Shuyu-
dc.contributor.authorShih, Ryan-
dc.contributor.authorLin, Haisong-
dc.contributor.authorTamayosa, Stephanie-
dc.contributor.authorHam, Brittany-
dc.contributor.authorStout, Phoenix-
dc.contributor.authorSalahi, Kamyar-
dc.contributor.authorWang, Zhaoqing-
dc.contributor.authorZhao, Chuanzhen-
dc.contributor.authorTan, Jiawei-
dc.contributor.authorEmaminejad, Sam-
dc.date.accessioned2022-07-06T11:28:43Z-
dc.date.available2022-07-06T11:28:43Z-
dc.date.issued2020-
dc.identifier.citationAdvanced Functional Materials, 2020, v. 30, n. 10, article no. 1908507-
dc.identifier.issn1616-301X-
dc.identifier.urihttp://hdl.handle.net/10722/313983-
dc.description.abstractWearable electroenzymatic sensors enable monitoring of clinically informative biomolecules in epidermally retrievable biofluids. Conventional wearable enzymatic sensors utilize Prussian Blue (a redox mediator) to achieve selectivity against electroactive interferents. However, the use of Prussian Blue presents fundamental challenges including: 1) the susceptibility of the sensor response to dynamic concentration variation of ionic species and 2) the poor operational stability due to the degradation of its framework. As an alternative wearable electroenzymatic sensor development methodology to bypass the aforementioned limitations, a mediator-free sensing interface is devised, comprising of a coupled platinum nanoparticle/multiwall carbon nanotube layer and a permselective membrane. The interface is adapted to develop sensors targeting glucose, lactate, and choline (as examples of informative metabolites and nutrients), showing high degrees of sensitivity, selectivity (against a wide panel of naturally present and diverse interfering species), stability (<6.5% signal drift over 20 h operation), and reliability of sensing operation in sweat samples. By integration within a readout board, a wireless sample-to-answer system is realized for on-body sweat biomarker analysis. This methodology can be adapted to target a wide panel of biomarkers in various biofluids, introducing a new sensor development direction for personal health monitoring.-
dc.languageeng-
dc.relation.ispartofAdvanced Functional Materials-
dc.subjectelectrochemical sensors-
dc.subjectmediator-free sensors-
dc.subjectmetabolite monitoring-
dc.subjectnutrient monitoring-
dc.subjectwearable biomarker sensors-
dc.titleA Mediator-Free Electroenzymatic Sensing Methodology to Mitigate Ionic and Electroactive Interferents' Effects for Reliable Wearable Metabolite and Nutrient Monitoring-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/adfm.201908507-
dc.identifier.scopuseid_2-s2.0-85076763351-
dc.identifier.volume30-
dc.identifier.issue10-
dc.identifier.spagearticle no. 1908507-
dc.identifier.epagearticle no. 1908507-
dc.identifier.eissn1616-3028-
dc.identifier.isiWOS:000502599600001-

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