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Article: Design Framework and Sensing System for Noninvasive Wearable Electroactive Drug Monitoring

TitleDesign Framework and Sensing System for Noninvasive Wearable Electroactive Drug Monitoring
Authors
Keywordsanalytical framework
boron-doped diamond electrode
differential pulse voltammetry
electroactive species
personalized dosing
wearable drug monitoring
Issue Date2020
Citation
ACS Sensors, 2020, v. 5, n. 1, p. 265-273 How to Cite?
AbstractWearable drug monitoring targeting epidermally retrievable biofluids (e.g., sweat) can enable a variety of applications, including drug compliance/abuse monitoring and personalized therapeutic drug dosing. In that regard, voltammetry-based approaches are suitable because they uniquely leverage the electroactive nature of target drug molecules for quantification, eliminating the reliance on the availability of recognition elements. However, to adapt such approaches for the envisioned application, three main challenges must be addressed: (1) constructing a sensitive voltammetric sensing interface with high signal-to-background ratio, (2) decoupling the confounding effect of endogenous electroactive species (naturally present in complex biofluid matrices) and baseline variation, and (3) realizing wireless voltammetric excitation and signal acquisition/transmission. To this end, first, a framework for the quantification of electroactive drugs is presented, which centers on the evaluation and determination of suitable sensing electrodes and characterization of the interference from a panel of physiologically relevant electroactive species. This framework was utilized to establish the design space and operational settings for the development of a coupled sensing system and analytical framework to render sample-to-answer drug readouts in complex biofluid matrices. The presented design framework and sensing system can serve as a basis for future wearable sensor development efforts aiming to monitor electroactive species such as pharmaceutical molecules.
Persistent Identifierhttp://hdl.handle.net/10722/313984
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLin, Shuyu-
dc.contributor.authorWang, Bo-
dc.contributor.authorYu, Wenzhuo-
dc.contributor.authorCastillo, Kait-
dc.contributor.authorHoffman, Claire-
dc.contributor.authorCheng, Xuanbing-
dc.contributor.authorZhao, Yichao-
dc.contributor.authorGao, Yu-
dc.contributor.authorWang, Zhaoqing-
dc.contributor.authorLin, Haisong-
dc.contributor.authorHojaiji, Hannaneh-
dc.contributor.authorTan, Jiawei-
dc.contributor.authorEmaminejad, Sam-
dc.date.accessioned2022-07-06T11:28:43Z-
dc.date.available2022-07-06T11:28:43Z-
dc.date.issued2020-
dc.identifier.citationACS Sensors, 2020, v. 5, n. 1, p. 265-273-
dc.identifier.urihttp://hdl.handle.net/10722/313984-
dc.description.abstractWearable drug monitoring targeting epidermally retrievable biofluids (e.g., sweat) can enable a variety of applications, including drug compliance/abuse monitoring and personalized therapeutic drug dosing. In that regard, voltammetry-based approaches are suitable because they uniquely leverage the electroactive nature of target drug molecules for quantification, eliminating the reliance on the availability of recognition elements. However, to adapt such approaches for the envisioned application, three main challenges must be addressed: (1) constructing a sensitive voltammetric sensing interface with high signal-to-background ratio, (2) decoupling the confounding effect of endogenous electroactive species (naturally present in complex biofluid matrices) and baseline variation, and (3) realizing wireless voltammetric excitation and signal acquisition/transmission. To this end, first, a framework for the quantification of electroactive drugs is presented, which centers on the evaluation and determination of suitable sensing electrodes and characterization of the interference from a panel of physiologically relevant electroactive species. This framework was utilized to establish the design space and operational settings for the development of a coupled sensing system and analytical framework to render sample-to-answer drug readouts in complex biofluid matrices. The presented design framework and sensing system can serve as a basis for future wearable sensor development efforts aiming to monitor electroactive species such as pharmaceutical molecules.-
dc.languageeng-
dc.relation.ispartofACS Sensors-
dc.subjectanalytical framework-
dc.subjectboron-doped diamond electrode-
dc.subjectdifferential pulse voltammetry-
dc.subjectelectroactive species-
dc.subjectpersonalized dosing-
dc.subjectwearable drug monitoring-
dc.titleDesign Framework and Sensing System for Noninvasive Wearable Electroactive Drug Monitoring-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/acssensors.9b02233-
dc.identifier.pmid31909594-
dc.identifier.scopuseid_2-s2.0-85078166920-
dc.identifier.volume5-
dc.identifier.issue1-
dc.identifier.spage265-
dc.identifier.epage273-
dc.identifier.eissn2379-3694-
dc.identifier.isiWOS:000510079300035-

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