Rapid and low-cost fabrication and integration of complex 3d microfluidic architectures for lab-on-body applications

Abstract

This paper reports a simple, scalable, and low-cost “CAD-to-3D device” fabrication and integration scheme, which renders 3D, flexible, and complex microfluidic architectures, capable of performing versatile biofluid sampling, manipulation, and sensing operations. Three representative devices for sweat collection, sample filtration, and simultaneous biofluid actuation and sensing are demonstrated to inform the utility of our fabrication scheme. The devised scheme can be adapted for the large-scale manufacturing of wearable bioanalytical devices, catalyzing the deployment of lab-on-body platforms for general population health monitoring.