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Article: Frequent Amplification of a chr19q13.41 MicroRNA Polycistron in Aggressive Primitive Neuroectodermal Brain Tumors

TitleFrequent Amplification of a chr19q13.41 MicroRNA Polycistron in Aggressive Primitive Neuroectodermal Brain Tumors
Authors
KeywordsCELLCYCLE
Issue Date2009
Citation
Cancer Cell, 2009, v. 16, n. 6, p. 533-546 How to Cite?
AbstractWe discovered a high-level amplicon involving the chr19q13.41 microRNA (miRNA) cluster (C19MC) in 11/45 (∼25%) primary CNS-PNET, which results in striking overexpression of miR-517c and 520g. Constitutive expression of miR-517c or 520g promotes in vitro and in vivo oncogenicity, modulates cell survival, and robustly enhances growth of untransformed human neural stem cells (hNSCs) in part by upregulating WNT pathway signaling and restricting differentiation of hNSCs. Remarkably, the C19MC amplicon, which is very rare in other brain tumors (1/263), identifies an aggressive subgroup of CNS-PNET with distinct gene-expression profiles, characteristic histology, and dismal survival. Our data implicate miR-517c and 520g as oncogenes and promising biological markers for CNS-PNET and provide important insights into oncogenic properties of the C19MC locus. © 2009 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/314023
ISSN
2023 Impact Factor: 48.8
2023 SCImago Journal Rankings: 17.507
PubMed Central ID
ISI Accession Number ID
Errata

 

DC FieldValueLanguage
dc.contributor.authorLi, Meihua-
dc.contributor.authorLee, Kyle F.-
dc.contributor.authorLu, Yuntao-
dc.contributor.authorClarke, Ian-
dc.contributor.authorShih, David-
dc.contributor.authorEberhart, Charles-
dc.contributor.authorCollins, V. Peter-
dc.contributor.authorVan Meter, Tim-
dc.contributor.authorPicard, Daniel-
dc.contributor.authorZhou, Limei-
dc.contributor.authorBoutros, Paul C.-
dc.contributor.authorModena, Piergiorgio-
dc.contributor.authorLiang, Muh Lii-
dc.contributor.authorScherer, Steve W.-
dc.contributor.authorBouffet, Eric-
dc.contributor.authorRutka, James T.-
dc.contributor.authorPomeroy, Scott L.-
dc.contributor.authorLau, Ching C.-
dc.contributor.authorTaylor, Michael D.-
dc.contributor.authorGajjar, Amar-
dc.contributor.authorDirks, Peter B.-
dc.contributor.authorHawkins, Cynthia E.-
dc.contributor.authorHuang, Annie-
dc.date.accessioned2022-07-06T11:28:53Z-
dc.date.available2022-07-06T11:28:53Z-
dc.date.issued2009-
dc.identifier.citationCancer Cell, 2009, v. 16, n. 6, p. 533-546-
dc.identifier.issn1535-6108-
dc.identifier.urihttp://hdl.handle.net/10722/314023-
dc.description.abstractWe discovered a high-level amplicon involving the chr19q13.41 microRNA (miRNA) cluster (C19MC) in 11/45 (∼25%) primary CNS-PNET, which results in striking overexpression of miR-517c and 520g. Constitutive expression of miR-517c or 520g promotes in vitro and in vivo oncogenicity, modulates cell survival, and robustly enhances growth of untransformed human neural stem cells (hNSCs) in part by upregulating WNT pathway signaling and restricting differentiation of hNSCs. Remarkably, the C19MC amplicon, which is very rare in other brain tumors (1/263), identifies an aggressive subgroup of CNS-PNET with distinct gene-expression profiles, characteristic histology, and dismal survival. Our data implicate miR-517c and 520g as oncogenes and promising biological markers for CNS-PNET and provide important insights into oncogenic properties of the C19MC locus. © 2009 Elsevier Inc. All rights reserved.-
dc.languageeng-
dc.relation.ispartofCancer Cell-
dc.subjectCELLCYCLE-
dc.titleFrequent Amplification of a chr19q13.41 MicroRNA Polycistron in Aggressive Primitive Neuroectodermal Brain Tumors-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ccr.2009.10.025-
dc.identifier.pmid19962671-
dc.identifier.pmcidPMC3431561-
dc.identifier.scopuseid_2-s2.0-70749095079-
dc.identifier.volume16-
dc.identifier.issue6-
dc.identifier.spage533-
dc.identifier.epage546-
dc.identifier.isiWOS:000272693700012-
dc.relation.erratumdoi:10.1016/j.ccr.2010.03.016-
dc.relation.erratumeid:eid_2-s2.0-77950514384-

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