File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Comparative epidemiology, phylogenetics, and transmission patterns of severe influenza A/H3N2 in Australia from 2003 to 2017

TitleComparative epidemiology, phylogenetics, and transmission patterns of severe influenza A/H3N2 in Australia from 2003 to 2017
Authors
KeywordsAustralia
epidemiology
H3N2 subtype
influenza A virus
phylogeography
public health
Issue Date2020
Citation
Influenza and Other Respiratory Viruses, 2020, v. 14 n. 6, p. 700-709 How to Cite?
AbstractBackground: Over the last two decades, Australia has experienced four severe influenza seasons caused by a predominance of influenza A (A/H3N2): 2003, 2007, 2012, and 2017. Methods: We compared the epidemiology, genetics, and transmission dynamics of severe A/H3N2 seasons in Australia from 2003 to 2017. Results: Since 2003, the proportion of notifications in 0-4 years old has decreased, while it has increased in the age group >80 years old (P <.001). The genetic diversity of circulating influenza A/H3N2 viruses has also increased over time with the number of single nucleotide polymorphisms significantly (P <.05) increasing. We also identified five residue positions within or near the receptor binding site of HA (144, 145, 159, 189, and 225) undergoing frequent mutations that are likely involved in significant antigenic drift and possibly severity. The Australian state of Victoria was identified as a frequent location for transmission either to or from other states and territories over the study years. The states of New South Wales and Queensland were also frequently implicated as locations of transmission to other states and territories but less so over the years. This indicates a stable but also changing dynamic of A/H3N2 circulation in Australia. Conclusion: These results have important implications for future influenza surveillance and control policy in the country. Reasons for the change in age-specific infection and increased genetic diversity of A/H3N2 viruses in recent years should be explored.
Persistent Identifierhttp://hdl.handle.net/10722/314223
ISSN
2023 Impact Factor: 4.3
2023 SCImago Journal Rankings: 1.485
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorXia, J-
dc.contributor.authorAdam, DC-
dc.contributor.authorMoa, A-
dc.contributor.authorChughtai, AA-
dc.contributor.authorBarr, IG-
dc.contributor.authorKomadina, N-
dc.contributor.authorMacIntyre, CR-
dc.date.accessioned2022-07-18T06:14:02Z-
dc.date.available2022-07-18T06:14:02Z-
dc.date.issued2020-
dc.identifier.citationInfluenza and Other Respiratory Viruses, 2020, v. 14 n. 6, p. 700-709-
dc.identifier.issn1750-2640-
dc.identifier.urihttp://hdl.handle.net/10722/314223-
dc.description.abstractBackground: Over the last two decades, Australia has experienced four severe influenza seasons caused by a predominance of influenza A (A/H3N2): 2003, 2007, 2012, and 2017. Methods: We compared the epidemiology, genetics, and transmission dynamics of severe A/H3N2 seasons in Australia from 2003 to 2017. Results: Since 2003, the proportion of notifications in 0-4 years old has decreased, while it has increased in the age group >80 years old (P <.001). The genetic diversity of circulating influenza A/H3N2 viruses has also increased over time with the number of single nucleotide polymorphisms significantly (P <.05) increasing. We also identified five residue positions within or near the receptor binding site of HA (144, 145, 159, 189, and 225) undergoing frequent mutations that are likely involved in significant antigenic drift and possibly severity. The Australian state of Victoria was identified as a frequent location for transmission either to or from other states and territories over the study years. The states of New South Wales and Queensland were also frequently implicated as locations of transmission to other states and territories but less so over the years. This indicates a stable but also changing dynamic of A/H3N2 circulation in Australia. Conclusion: These results have important implications for future influenza surveillance and control policy in the country. Reasons for the change in age-specific infection and increased genetic diversity of A/H3N2 viruses in recent years should be explored.-
dc.languageeng-
dc.relation.ispartofInfluenza and Other Respiratory Viruses-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectAustralia-
dc.subjectepidemiology-
dc.subjectH3N2 subtype-
dc.subjectinfluenza A virus-
dc.subjectphylogeography-
dc.subjectpublic health-
dc.titleComparative epidemiology, phylogenetics, and transmission patterns of severe influenza A/H3N2 in Australia from 2003 to 2017-
dc.typeArticle-
dc.identifier.emailAdam, DC: dcadam@hku.hk-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1111/irv.12772-
dc.identifier.pmid32558378-
dc.identifier.pmcidPMC7578330-
dc.identifier.scopuseid_2-s2.0-85086711075-
dc.identifier.hkuros334165-
dc.identifier.volume14-
dc.identifier.issue6-
dc.identifier.spage700-
dc.identifier.epage709-
dc.identifier.isiWOS:000547951700001-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats