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- Publisher Website: 10.18632/oncotarget.7623
- Scopus: eid_2-s2.0-84975474049
- PMID: 27229762
- WOS: WOS:000375699000106
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Article: Genetic scores based on risk-associated single nucleotide polymorphisms (SNPs) can reveal inherited risk of renal cell carcinoma
Title | Genetic scores based on risk-associated single nucleotide polymorphisms (SNPs) can reveal inherited risk of renal cell carcinoma |
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Authors | |
Keywords | Chinese Genetic score Renal cell carcinoma SNPs |
Issue Date | 2016 |
Citation | Oncotarget, 2016, v. 7, n. 14, p. 18631-18637 How to Cite? |
Abstract | The objective of this study was to evaluate whether renal cell carcinoma (RCC) riskassociated single nucleotide polymorphisms (SNPs) could reflect the individual inherited risks of RCC. A total of 346 RCC patients and 1,130 controls were recruited in this casecontrol study. Genetic scores were calculated for each individual based on the odds ratios and frequencies of risk-associated SNPs. Four SNPs were significantly associated with RCC in Chinese population. Two genetic score models were established, genetic score 1 (rs10054504, rs7023329 and rs718314) and genetic score 2 (rs10054504, rs7023329 and rs1049380). For genetic score 1, the individual likelihood of RCC with low (< 0.8), medium (0.8-1.2) and high (≥ 1.2) genetic score 1 was 15.61%, 22.25% and 33.92% respectively (P-trend=6.88×10-7). For genetic score 2, individual with low (< 0.8), medium (0.8-1.2) and high (≥ 1.2) genetic score 2 would have likelihood of RCC as 14.39%, 24.54% and 36.48%, respectively (P-trend=1.27×10-10). The area under the receiver operating curve (AUC) of genetic score 1 was 0.626, and AUC of genetic score 2 was 0.658. We concluded that genetic score can reveal personal risk and inherited risk of RCC, especially when family history is not available. |
Persistent Identifier | http://hdl.handle.net/10722/314348 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Wu, Yishuo | - |
dc.contributor.author | Zhang, Ning | - |
dc.contributor.author | Li, Kaiwen | - |
dc.contributor.author | Chen, Haitao | - |
dc.contributor.author | Lin, Xiaolin | - |
dc.contributor.author | Yu, Yang | - |
dc.contributor.author | Gou, Yuancheng | - |
dc.contributor.author | Hou, Jiangang | - |
dc.contributor.author | Jiang, Deke | - |
dc.contributor.author | Na, Rong | - |
dc.contributor.author | Wang, Xiang | - |
dc.contributor.author | Ding, Qiang | - |
dc.contributor.author | Xu, Jianfeng | - |
dc.date.accessioned | 2022-07-20T12:03:42Z | - |
dc.date.available | 2022-07-20T12:03:42Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Oncotarget, 2016, v. 7, n. 14, p. 18631-18637 | - |
dc.identifier.uri | http://hdl.handle.net/10722/314348 | - |
dc.description.abstract | The objective of this study was to evaluate whether renal cell carcinoma (RCC) riskassociated single nucleotide polymorphisms (SNPs) could reflect the individual inherited risks of RCC. A total of 346 RCC patients and 1,130 controls were recruited in this casecontrol study. Genetic scores were calculated for each individual based on the odds ratios and frequencies of risk-associated SNPs. Four SNPs were significantly associated with RCC in Chinese population. Two genetic score models were established, genetic score 1 (rs10054504, rs7023329 and rs718314) and genetic score 2 (rs10054504, rs7023329 and rs1049380). For genetic score 1, the individual likelihood of RCC with low (< 0.8), medium (0.8-1.2) and high (≥ 1.2) genetic score 1 was 15.61%, 22.25% and 33.92% respectively (P-trend=6.88×10-7). For genetic score 2, individual with low (< 0.8), medium (0.8-1.2) and high (≥ 1.2) genetic score 2 would have likelihood of RCC as 14.39%, 24.54% and 36.48%, respectively (P-trend=1.27×10-10). The area under the receiver operating curve (AUC) of genetic score 1 was 0.626, and AUC of genetic score 2 was 0.658. We concluded that genetic score can reveal personal risk and inherited risk of RCC, especially when family history is not available. | - |
dc.language | eng | - |
dc.relation.ispartof | Oncotarget | - |
dc.subject | Chinese | - |
dc.subject | Genetic score | - |
dc.subject | Renal cell carcinoma | - |
dc.subject | SNPs | - |
dc.title | Genetic scores based on risk-associated single nucleotide polymorphisms (SNPs) can reveal inherited risk of renal cell carcinoma | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.18632/oncotarget.7623 | - |
dc.identifier.pmid | 27229762 | - |
dc.identifier.pmcid | PMC4951315 | - |
dc.identifier.scopus | eid_2-s2.0-84975474049 | - |
dc.identifier.volume | 7 | - |
dc.identifier.issue | 14 | - |
dc.identifier.spage | 18631 | - |
dc.identifier.epage | 18637 | - |
dc.identifier.eissn | 1949-2553 | - |
dc.identifier.isi | WOS:000375699000106 | - |