File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Performance of the Prostate Health Index in predicting prostate biopsy outcomes among men with a negative digital rectal examination and transrectal ultrasonography

TitlePerformance of the Prostate Health Index in predicting prostate biopsy outcomes among men with a negative digital rectal examination and transrectal ultrasonography
Authors
Keywordsprostate cancer
Prostate Health Index
prostate-specific antigen
receiver operating curve
[-2]proPSA
Issue Date2016
Citation
Asian Journal of Andrology, 2016, v. 18, n. 4, p. 633-638 How to Cite?
AbstractThe [-2]proPSA (p2PSA) and its derivatives, the p2PSA-to-free PSA ratio (%p2PSA), and the Prostate Health Index (PHI) have greatly improved discrimination between men with and without prostate cancer (PCa) in prostate biopsies. However, little is known about their performance in cases where a digital rectal examination (DRE) and transrectal ultrasonography (TRUS) are negative. A prospective cohort of 261 consecutive patients in China with negative DRE and TRUS were recruited and underwent prostate biopsies. A serum sample had collected before the biopsy was used to measure various PSA derivatives, including total prostate-specific antigen (tPSA), free PSA, and p2PSA. For each patient, the free-to-total PSA ratio (%fPSA), PSA density (PSAD), p2PSA-to-free PSA ratio (%p2PSA), and PHI were calculated. Discriminative performance was assessed using the area under the receiver operating characteristic curve (AUC) and the biopsy rate at 91% sensitivity. The AUC scores within the entire cohort with respect to age, tPSA, %fPSA, PSAD, p2PSA, %p2PSA, and PHI were 0.598, 0.751, 0.646, 0.789, 0.814, 0.808, and 0.853, respectively. PHI was the best predictor of prostate biopsy results, especially in patients with a tPSA of 10.1-20 ng ml-1. Compared with other markers, at a sensitivity of 91%, PHI was the most useful for determining which men did not need to undergo biopsy, thereby avoiding unnecessary procedures. The use of PHI could improve the accuracy of PCa detection by predicting prostate biopsy outcomes among men with a negative DRE and TRUS in China.
Persistent Identifierhttp://hdl.handle.net/10722/314349
ISSN
2021 Impact Factor: 3.054
2020 SCImago Journal Rankings: 0.701
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYu, Guo Peng-
dc.contributor.authorNa, Rong-
dc.contributor.authorYe, Ding Wei-
dc.contributor.authorQi, Jun-
dc.contributor.authorLiu, Fang-
dc.contributor.authorChen, Hai Tao-
dc.contributor.authorWu, Yi Shuo-
dc.contributor.authorZhang, Gui Ming-
dc.contributor.authorSun, Jie Lin-
dc.contributor.authorZhu, Yao-
dc.contributor.authorHuang, Li Qun-
dc.contributor.authorRen, Shan Cheng-
dc.contributor.authorJiang, De Ke-
dc.contributor.authorZheng, S.-
dc.contributor.authorJiang, Hao Wen-
dc.contributor.authorSun, Ying Hao-
dc.contributor.authorDing, Qiang-
dc.contributor.authorXu, Jianfeng-
dc.date.accessioned2022-07-20T12:03:43Z-
dc.date.available2022-07-20T12:03:43Z-
dc.date.issued2016-
dc.identifier.citationAsian Journal of Andrology, 2016, v. 18, n. 4, p. 633-638-
dc.identifier.issn1008-682X-
dc.identifier.urihttp://hdl.handle.net/10722/314349-
dc.description.abstractThe [-2]proPSA (p2PSA) and its derivatives, the p2PSA-to-free PSA ratio (%p2PSA), and the Prostate Health Index (PHI) have greatly improved discrimination between men with and without prostate cancer (PCa) in prostate biopsies. However, little is known about their performance in cases where a digital rectal examination (DRE) and transrectal ultrasonography (TRUS) are negative. A prospective cohort of 261 consecutive patients in China with negative DRE and TRUS were recruited and underwent prostate biopsies. A serum sample had collected before the biopsy was used to measure various PSA derivatives, including total prostate-specific antigen (tPSA), free PSA, and p2PSA. For each patient, the free-to-total PSA ratio (%fPSA), PSA density (PSAD), p2PSA-to-free PSA ratio (%p2PSA), and PHI were calculated. Discriminative performance was assessed using the area under the receiver operating characteristic curve (AUC) and the biopsy rate at 91% sensitivity. The AUC scores within the entire cohort with respect to age, tPSA, %fPSA, PSAD, p2PSA, %p2PSA, and PHI were 0.598, 0.751, 0.646, 0.789, 0.814, 0.808, and 0.853, respectively. PHI was the best predictor of prostate biopsy results, especially in patients with a tPSA of 10.1-20 ng ml-1. Compared with other markers, at a sensitivity of 91%, PHI was the most useful for determining which men did not need to undergo biopsy, thereby avoiding unnecessary procedures. The use of PHI could improve the accuracy of PCa detection by predicting prostate biopsy outcomes among men with a negative DRE and TRUS in China.-
dc.languageeng-
dc.relation.ispartofAsian Journal of Andrology-
dc.subjectprostate cancer-
dc.subjectProstate Health Index-
dc.subjectprostate-specific antigen-
dc.subjectreceiver operating curve-
dc.subject[-2]proPSA-
dc.titlePerformance of the Prostate Health Index in predicting prostate biopsy outcomes among men with a negative digital rectal examination and transrectal ultrasonography-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.4103/1008-682X.172823-
dc.identifier.pmid26975483-
dc.identifier.pmcidPMC4955192-
dc.identifier.scopuseid_2-s2.0-84977618464-
dc.identifier.volume18-
dc.identifier.issue4-
dc.identifier.spage633-
dc.identifier.epage638-
dc.identifier.eissn1745-7262-
dc.identifier.isiWOS:000380245900024-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats