File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Germline genetic variations in PDZD2 and ITPR2 genes are associated with clear cell renal cell carcinoma in Chinese population

TitleGermline genetic variations in PDZD2 and ITPR2 genes are associated with clear cell renal cell carcinoma in Chinese population
Authors
Zhang, NingWu, YishuoGong, JianLi, KaiwenLin, XiaolinChen, HaitaoYu, YangGou, YuanchengHou, JiangangJiang, DekeNa, RongWang, XiangDing, QiangXu, Jianfeng
KeywordsChinese
Genome-wide association
Renal cell carcinoma
SNPs
Issue Date2017
Citation
Oncotarget, 2017, v. 8, n. 15, p. 24196-24201 How to Cite?
DOI: http://dx.doi.org/10.18632/oncotarget.6917
AbstractGenome-wide association studies (GWAS) of renal cell carcinoma (RCC) have identified single nucleotide polymorphisms (SNPs) associated with RCC in European and African American population. In this study, we evaluated whether these SNPs are associated with clear cell RCC (ccRCC) in Chinese population. All reported RCC riskassociated SNPs from GWAS were evaluated in 346 ccRCC cases and 1,130 controls. Rs10054504 (at PDZD2, Odds ratio, OR = 0.71, 95%CI:0.59-0.86, P = 0.0006), rs718314 (at ITPR2, OR = 0.56, 95%CI:0.45-0.69, P = 5.26×10-8) and rs1049380 (at ITPR2, by dominant model, OR = 1.58, 95%CI:1.18-2.13, P = 0.0025) were significantly associated with ccRCC risk in Chinese population. To conclude, genetic variations in PDZD2 and ITPR2 are ccRCC-risk associated in Chinese population.
Persistent Identifierhttp://hdl.handle.net/10722/314396
ISI Accession Number ID
WOS:000399340300014

 

DC FieldValueLanguage
dc.contributor.authorZhang, Ning-
dc.contributor.authorWu, Yishuo-
dc.contributor.authorGong, Jian-
dc.contributor.authorLi, Kaiwen-
dc.contributor.authorLin, Xiaolin-
dc.contributor.authorChen, Haitao-
dc.contributor.authorYu, Yang-
dc.contributor.authorGou, Yuancheng-
dc.contributor.authorHou, Jiangang-
dc.contributor.authorJiang, Deke-
dc.contributor.authorNa, Rong-
dc.contributor.authorWang, Xiang-
dc.contributor.authorDing, Qiang-
dc.contributor.authorXu, Jianfeng-
dc.date.accessioned2022-07-20T12:03:56Z-
dc.date.available2022-07-20T12:03:56Z-
dc.date.issued2017-
dc.identifier.citationOncotarget, 2017, v. 8, n. 15, p. 24196-24201-
dc.identifier.urihttp://hdl.handle.net/10722/314396-
dc.description.abstractGenome-wide association studies (GWAS) of renal cell carcinoma (RCC) have identified single nucleotide polymorphisms (SNPs) associated with RCC in European and African American population. In this study, we evaluated whether these SNPs are associated with clear cell RCC (ccRCC) in Chinese population. All reported RCC riskassociated SNPs from GWAS were evaluated in 346 ccRCC cases and 1,130 controls. Rs10054504 (at PDZD2, Odds ratio, OR = 0.71, 95%CI:0.59-0.86, P = 0.0006), rs718314 (at ITPR2, OR = 0.56, 95%CI:0.45-0.69, P = 5.26×10-8) and rs1049380 (at ITPR2, by dominant model, OR = 1.58, 95%CI:1.18-2.13, P = 0.0025) were significantly associated with ccRCC risk in Chinese population. To conclude, genetic variations in PDZD2 and ITPR2 are ccRCC-risk associated in Chinese population.-
dc.languageeng-
dc.relation.ispartofOncotarget-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectChinese-
dc.subjectGenome-wide association-
dc.subjectRenal cell carcinoma-
dc.subjectSNPs-
dc.titleGermline genetic variations in PDZD2 and ITPR2 genes are associated with clear cell renal cell carcinoma in Chinese population-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.18632/oncotarget.6917-
dc.identifier.scopuseid_2-s2.0-85017554772-
dc.identifier.volume8-
dc.identifier.issue15-
dc.identifier.spage24196-
dc.identifier.epage24201-
dc.identifier.eissn1949-2553-
dc.identifier.isiWOS:000399340300014-

Export via OAI-PMH Interface in XML Formats

OR

Export to Other Non-XML Formats