File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Prostate health index significantly reduced unnecessary prostate biopsies in patients with PSA 2-10 ng/mL and PSA >10 ng/mL: Results from a Multicenter Study in China

TitleProstate health index significantly reduced unnecessary prostate biopsies in patients with PSA 2-10 ng/mL and PSA >10 ng/mL: Results from a Multicenter Study in China
Authors
KeywordsChinese
p2PSA
prostate biopsy
Prostate Health Index
Issue Date2017
Citation
Prostate, 2017, v. 77, n. 11, p. 1221-1229 How to Cite?
AbstractBackground: The performance of prostate health index (phi) in predicting prostate biopsy outcomes has been well established for patients with prostate-specific antigen (PSA) values between 2 and 10 ng/mL. However, the performance of phi remains unknown in patients with PSA >10 ng/mL, the vast majority in Chinese biopsy patients. We aimed to assess the ability of phi to predict prostate cancer (PCa) and high-grade disease (Gleason Score ≥7) on biopsy in a Chinese population. Methods: This is a prospective, observational, multi-center study of consecutive patients who underwent a transrectal ultrasound guided prostate biopsy at four hospitals in Shanghai, China from August 2013 to December 2014. Results: In the cohort of 1538 patients, the detection rate of PCa was 40.2%. phi had a significantly better predictive performance for PCa than total PSA (tPSA). The areas under the receiver operating characteristic curve (AUC) were 0.90 and 0.79 for phi and tPSA, respectively, P < 0.0001. A considerable proportion of patients in the cohort had PSAs >10 ng/mL (N = 838, 54.5%). The detection rates of PCa were 35.9% and 57.7% in patients with tPSA 10.1-20 and 20.1-50 ng/mL, respectively. The AUCs of phi (0.79 and 0.89, for these two groups, respectively) were also significantly higher than tPSA (0.57 and 0.63, respectively), both P < 0.0001. If a phi ≤35 was used as the cutoff, 599/1538 (39%) biopsies could have been avoided at a cost of missing small numbers of PCa patients: 49 (7.93%) PCa patients, including 18 (3.69%) high-grade tumors. Conclusions: Results from this study suggest that phi can be used to predict PCa and high-grade disease in Chinese men with high PSA levels (>10 ng/mL).
Persistent Identifierhttp://hdl.handle.net/10722/314398
ISSN
2021 Impact Factor: 4.012
2020 SCImago Journal Rankings: 1.295

 

DC FieldValueLanguage
dc.contributor.authorNa, Rong-
dc.contributor.authorYe, Dingwei-
dc.contributor.authorQi, Jun-
dc.contributor.authorLiu, Fang-
dc.contributor.authorHelfand, Brian T.-
dc.contributor.authorBrendler, Charles B.-
dc.contributor.authorConran, Carly A.-
dc.contributor.authorPackiam, Vignesh-
dc.contributor.authorGong, Jian-
dc.contributor.authorWu, Yishuo-
dc.contributor.authorZheng, Siqun L.-
dc.contributor.authorMo, Zengnan-
dc.contributor.authorDing, Qiang-
dc.contributor.authorSun, Yinghao-
dc.contributor.authorXu, Jianfeng-
dc.date.accessioned2022-07-20T12:03:56Z-
dc.date.available2022-07-20T12:03:56Z-
dc.date.issued2017-
dc.identifier.citationProstate, 2017, v. 77, n. 11, p. 1221-1229-
dc.identifier.issn0270-4137-
dc.identifier.urihttp://hdl.handle.net/10722/314398-
dc.description.abstractBackground: The performance of prostate health index (phi) in predicting prostate biopsy outcomes has been well established for patients with prostate-specific antigen (PSA) values between 2 and 10 ng/mL. However, the performance of phi remains unknown in patients with PSA >10 ng/mL, the vast majority in Chinese biopsy patients. We aimed to assess the ability of phi to predict prostate cancer (PCa) and high-grade disease (Gleason Score ≥7) on biopsy in a Chinese population. Methods: This is a prospective, observational, multi-center study of consecutive patients who underwent a transrectal ultrasound guided prostate biopsy at four hospitals in Shanghai, China from August 2013 to December 2014. Results: In the cohort of 1538 patients, the detection rate of PCa was 40.2%. phi had a significantly better predictive performance for PCa than total PSA (tPSA). The areas under the receiver operating characteristic curve (AUC) were 0.90 and 0.79 for phi and tPSA, respectively, P < 0.0001. A considerable proportion of patients in the cohort had PSAs >10 ng/mL (N = 838, 54.5%). The detection rates of PCa were 35.9% and 57.7% in patients with tPSA 10.1-20 and 20.1-50 ng/mL, respectively. The AUCs of phi (0.79 and 0.89, for these two groups, respectively) were also significantly higher than tPSA (0.57 and 0.63, respectively), both P < 0.0001. If a phi ≤35 was used as the cutoff, 599/1538 (39%) biopsies could have been avoided at a cost of missing small numbers of PCa patients: 49 (7.93%) PCa patients, including 18 (3.69%) high-grade tumors. Conclusions: Results from this study suggest that phi can be used to predict PCa and high-grade disease in Chinese men with high PSA levels (>10 ng/mL).-
dc.languageeng-
dc.relation.ispartofProstate-
dc.subjectChinese-
dc.subjectp2PSA-
dc.subjectprostate biopsy-
dc.subjectProstate Health Index-
dc.titleProstate health index significantly reduced unnecessary prostate biopsies in patients with PSA 2-10 ng/mL and PSA &gt;10 ng/mL: Results from a Multicenter Study in China-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/pros.23382-
dc.identifier.pmid28664580-
dc.identifier.scopuseid_2-s2.0-85021753943-
dc.identifier.volume77-
dc.identifier.issue11-
dc.identifier.spage1221-
dc.identifier.epage1229-
dc.identifier.eissn1097-0045-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats