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Article: TEX15: A DNA repair gene associated with prostate cancer risk in Han Chinese

TitleTEX15: A DNA repair gene associated with prostate cancer risk in Han Chinese
Authors
KeywordsChinese
DNA repair
exome array
genome-wide association study
prostate cancer
Issue Date2017
Citation
Prostate, 2017, v. 77, n. 12, p. 1271-1278 How to Cite?
AbstractBackground: Both common and rare genetic variants may contribute to risk of developing prostate cancer. Genome-wide association studies (GWASs) have identified ∼100 independent, common variants associated with prostate cancer risk. However, little is known about the association of rare variants (minor allele frequency [MAF] <1%) in the genome with prostate cancer risk. Methods: A two-stage study was used to test the association of rare, deleterious coding variants, annotated using predictive algorithms, with prostate cancer risk in Chinese men. Predicted rare, deleterious coding variants in the Illumina HumanExome-12 v1.1 beadchip were first evaluated in 1343 prostate cancer patients and 1008 controls. Significant variants were then validated in an additional 1816 prostate cancer patients and 1549 controls. Results: In the discovery stage, 14 predicted rare, deleterious coding variants were significantly associated with prostate cancer risk (P < 0.01). In the confirmation stage, Q1631H in TEX15 (rs142485241), a DNA repair gene, was significantly associated with prostate cancer risk (P = 0.0069). The estimated odds ratio (OR) of the variant in the combined analysis was 3.24 (95% Confidence Interval 1.85-6.06), P = 8.81 × 10−5. Additionally, rs28756990 (V741F) at MLH3 (P = 0.06) and rs2961144 (I126V) at OR2A5 (P = 0.065) were marginally associated with prostate cancer risk in the replication stage. Conclusions: Our study provided preliminary evidence that the rare variant Q1631H in DNA repair gene TEX15 is associated with prostate cancer risk. This finding complements known common prostate cancer risk-associated variants and suggests the possible role of DNA repair genes in prostate cancer development.
Persistent Identifierhttp://hdl.handle.net/10722/314400
ISSN
2021 Impact Factor: 4.012
2020 SCImago Journal Rankings: 1.295

 

DC FieldValueLanguage
dc.contributor.authorLin, Xiaoling-
dc.contributor.authorChen, Zhongzhong-
dc.contributor.authorGao, Peng-
dc.contributor.authorGao, Zhimei-
dc.contributor.authorChen, Haitao-
dc.contributor.authorQi, Jun-
dc.contributor.authorLiu, Fang-
dc.contributor.authorYe, Dingwei-
dc.contributor.authorJiang, Haowen-
dc.contributor.authorNa, Rong-
dc.contributor.authorYu, Hongjie-
dc.contributor.authorShi, Rong-
dc.contributor.authorLu, Daru-
dc.contributor.authorZheng, Siqun Lilly-
dc.contributor.authorMo, Zengnan-
dc.contributor.authorSun, Yinghao-
dc.contributor.authorDing, Qiang-
dc.contributor.authorXu, Jianfeng-
dc.date.accessioned2022-07-20T12:03:57Z-
dc.date.available2022-07-20T12:03:57Z-
dc.date.issued2017-
dc.identifier.citationProstate, 2017, v. 77, n. 12, p. 1271-1278-
dc.identifier.issn0270-4137-
dc.identifier.urihttp://hdl.handle.net/10722/314400-
dc.description.abstractBackground: Both common and rare genetic variants may contribute to risk of developing prostate cancer. Genome-wide association studies (GWASs) have identified ∼100 independent, common variants associated with prostate cancer risk. However, little is known about the association of rare variants (minor allele frequency [MAF] <1%) in the genome with prostate cancer risk. Methods: A two-stage study was used to test the association of rare, deleterious coding variants, annotated using predictive algorithms, with prostate cancer risk in Chinese men. Predicted rare, deleterious coding variants in the Illumina HumanExome-12 v1.1 beadchip were first evaluated in 1343 prostate cancer patients and 1008 controls. Significant variants were then validated in an additional 1816 prostate cancer patients and 1549 controls. Results: In the discovery stage, 14 predicted rare, deleterious coding variants were significantly associated with prostate cancer risk (P < 0.01). In the confirmation stage, Q1631H in TEX15 (rs142485241), a DNA repair gene, was significantly associated with prostate cancer risk (P = 0.0069). The estimated odds ratio (OR) of the variant in the combined analysis was 3.24 (95% Confidence Interval 1.85-6.06), P = 8.81 × 10−5. Additionally, rs28756990 (V741F) at MLH3 (P = 0.06) and rs2961144 (I126V) at OR2A5 (P = 0.065) were marginally associated with prostate cancer risk in the replication stage. Conclusions: Our study provided preliminary evidence that the rare variant Q1631H in DNA repair gene TEX15 is associated with prostate cancer risk. This finding complements known common prostate cancer risk-associated variants and suggests the possible role of DNA repair genes in prostate cancer development.-
dc.languageeng-
dc.relation.ispartofProstate-
dc.subjectChinese-
dc.subjectDNA repair-
dc.subjectexome array-
dc.subjectgenome-wide association study-
dc.subjectprostate cancer-
dc.titleTEX15: A DNA repair gene associated with prostate cancer risk in Han Chinese-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/pros.23387-
dc.identifier.pmid28730685-
dc.identifier.scopuseid_2-s2.0-85027401508-
dc.identifier.volume77-
dc.identifier.issue12-
dc.identifier.spage1271-
dc.identifier.epage1278-
dc.identifier.eissn1097-0045-

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